{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:54:29Z","timestamp":1793170469002,"version":"4.5.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0146886","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T19:25:14Z","timestamp":1453404314000},"page":"e0146886","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Nikita M.","family":"Bajwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shina","family":"Halavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette D.","family":"Semple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Noble-Haeusslein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Baghchechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hiroto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Obenaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Faul M, Xu L, Wald MM, Coronado VG. Traumatic brain injury in the United States: Emergency department visits, hospitalizations and deaths 2002\u20132006. Atlanta, GA; 2010.","DOI":"10.15620\/cdc.5571"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/jamaneurol.2015.0206","article-title":"Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes","volume":"72","author":"JF Strain","year":"2015","journal-title":"JAMA Neurol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/87565641.2015.1016161","article-title":"Post-Season Neurophysiological Deficits Assessed by ImPACT and fMRI in Athletes Competing in American Football","volume":"40","author":"EA Nauman","year":"2015","journal-title":"Dev Neuropsychol"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1001\/jamapediatrics.2015.0210","article-title":"Incidence of Concussion During Practice and Games in Youth, High School, and Collegiate American Football Players","volume":"169","author":"TP Dompier","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/02699052.2013.859735","article-title":"The negative impact of traumatic brain injury (TBI) on bone in a mouse model","volume":"28","author":"H Yu","year":"2014","journal-title":"Brain Inj"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury: A brief overview","volume":"21","author":"JA Langlois","year":"2006","journal-title":"J Head Trauma Rehabil"},{"issue":"8","key":"ref7","first-page":"994","article-title":"Prospectively assessed clinical outcomes in concussive blast vs nonblast traumatic brain injury among evacuated US military personnel","volume":"71","author":"CL Mac Donald","year":"2014","journal-title":"JAMA"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11682-015-9399-z","article-title":"Traumatic brain injury in the US military: Epidemiology and key clinical and research programs","volume":"9","author":"KM Helmick","year":"2015","journal-title":"Brain Imaging Behav"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuropsychologia.2015.10.008","article-title":"Perceptual organization deficits in traumatic brain injury patients","volume":"78","author":"TL Costa","year":"2015","journal-title":"Neuropsychologia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pbb.2013.04.001","article-title":"Short and long-term motor and behavioral effects of diazoxide and dimethyl sulfoxide administration in the mouse after traumatic brain injury","volume":"108","author":"CS Budinich","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"e101842","DOI":"10.1371\/journal.pone.0101842","article-title":"Depression and health related quality of life in adolescent survivors of a traumatic brain injury: a pilot study","volume":"9","author":"A Di Battista","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2010.04.004","article-title":"Neuroanatomical correlation of behavioral deficits in the CCI model of TBI","volume":"190","author":"NB Chauhan","year":"2010","journal-title":"J Neurosci Methods"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/brain\/awv139","article-title":"Military blast exposure, ageing and white matter integrity","volume":"138","author":"BB Trotter","year":"2015","journal-title":"Brain [Internet]"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/87565641.2015.1020945","article-title":"DTI Detection of Longitudinal WM Abnormalities Due to Accumulated Head Impacts","volume":"40","author":"IY Chun","year":"2015","journal-title":"Dev Neuropsychol [Internet]"},{"key":"ref15","unstructured":"Gerberding JL, Binder S. Report to congress on mild traumatic brain injury in the united states: Steps to prevent a serious public health problem. Atlanta, GA; 2003."},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/02699050410001720158","article-title":"Mild traumatic brain injury in the United States, 1998\u20132000","volume":"19","author":"JJ Bazarian","year":"2005","journal-title":"Brain Inj"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1471-4159.2011.07377.x","article-title":"Tumor necrosis factor-\u03b1 synthesis inhibitor, 3,6\u2019-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice","volume":"118","author":"R Baratz","year":"2011","journal-title":"J Neurochem"},{"key":"ref18","article-title":"Encyclopedia of Mental Health","author":"A Obenaus","year":"2015"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/026990598122656","article-title":"Mood disorders following traumatic brain injury: Identifying the extent of the problem and the people at risk","volume":"12","author":"A Bowen","year":"1998","journal-title":"Brain Inj"},{"issue":"1","key":"ref20","first-page":"13","article-title":"Mood Disorders After TBI. Psychiatr Clin North Am [Internet]","volume":"37","author":"RE Jorge","year":"2014","journal-title":"Elsevier Inc"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1176\/jnp.15.2.155","article-title":"Clinical correlates of aggressive behavior after traumatic brain injury","volume":"15","author":"A Tateno","year":"2003","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"April","key":"ref22","first-page":"69","article-title":"Repetitive concussions in adolescent athletes\u2014translating clinical and experimental research into perspectives on rehabilitation strategies","volume":"6","author":"BD Semple","year":"2015","journal-title":"Front Neurol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/08977150252932389","article-title":"Repeated mild brain injuries result in cognitive impairment in B6C3F1 mice","volume":"19","author":"SM DeFord","year":"2002","journal-title":"J Neurotrauma"},{"issue":"13","key":"ref24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1089\/neu.2013.3255","article-title":"The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy","volume":"31","author":"AL Petraglia","year":"2014","journal-title":"J Neurotrauma"},{"key":"ref25","unstructured":"Obenaus A, Huang L, Coats JS, Hartman R, Badaut J, Ashwal S. Animal Models. In: Mild Traumatic Brain Injury in Children and Adolescents: From Basic Science to Clinical Management. 2012. p. 53\u201374."},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/neu.2006.0011","article-title":"Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury","volume":"24","author":"DL Brody","year":"2007","journal-title":"J Neurotrauma"},{"issue":"18","key":"ref27","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1089\/neu.2012.2498","article-title":"Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes","volume":"29","author":"B Mouzon","year":"2012","journal-title":"J Neurotrauma"},{"key":"ref28","first-page":"272976","article-title":"Characterization of Closed Head Impact Injury in Rat","volume":"2015","author":"Y Hua","year":"2015","journal-title":"Biomed Res Int"},{"issue":"7482","key":"ref29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature12808","article-title":"Transcranial amelioration of inflammation and cell death after brain injury","volume":"505","author":"TL Roth","year":"2013","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.expneurol.2013.09.016","article-title":"Juvenile traumatic brain injury evolves into a chronic brain disorder: Behavioral and histological changes over 6months","volume":"250","author":"JE Kamper","year":"2013","journal-title":"Exp Neurol"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1089\/neu.2011.1883","article-title":"Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthood","volume":"29","author":"DO Ajao","year":"2012","journal-title":"J Neurotrauma"},{"key":"ref32","first-page":"12","article-title":"Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury","volume":"5","author":"J Luo","year":"2014","journal-title":"Front Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fneur.2013.00154","article-title":"Primary blast traumatic brain injury in the rat: relating diffusion tensor imaging and behavior","volume":"4","author":"MD Budde","year":"2013","journal-title":"Front Neurol"},{"key":"ref34","first-page":"1","article-title":"Immune Activation Promotes Depression 1 Month After Diffuse Brain Injury: A Role for Primed Microglia","author":"AM Fenn","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"e74510","DOI":"10.1371\/journal.pone.0074510","article-title":"Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in mice","volume":"8","author":"KC Klemenhagen","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"e103386","DOI":"10.1371\/journal.pone.0103386","article-title":"Sociosexual and communication deficits after traumatic injury to the developing murine brain","volume":"9","author":"BD Semple","year":"2014","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0166-4328(95)00264-2","article-title":"Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rat : physiological, histological and behavioral correlates","volume":"79","author":"JS Soblosky","year":"1996","journal-title":"Behav Brain Res"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.nicl.2012.08.001","article-title":"Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury","volume":"1","author":"V Donovan","year":"2012","journal-title":"NeuroImage Clin"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/jcbfm.2014.6","article-title":"Repeated mild traumatic brain injury results in long-term white-matter disruption","volume":"34","author":"V Donovan","year":"2014","journal-title":"J Cereb blood flow Metab"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1089\/neu.2011.1883","article-title":"Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthood","volume":"29","author":"DO Ajao","year":"2012","journal-title":"J Neurotrauma"},{"key":"ref41","first-page":"1","article-title":"A novel closed-head model of mild traumatic brain injury using focal primary overpressure blast to the cranium in mice","author":"NH Guley","year":"2015","journal-title":"J Neurotrauma"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fneur.2015.00132","article-title":"Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats","volume":"6","author":"HO Awwad","year":"2015","journal-title":"Front Neurol"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1553-2712.2004.tb00761.x","article-title":"Multiple Episodes of Mild Traumatic Brain Injury Result in Impaired Cognitive Performance in Mice","volume":"11","author":"CE Creeley","year":"2004","journal-title":"Acad Emerg Med"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2011.09.003","article-title":"A mouse model of human repetitive mild traumatic brain injury","volume":"203","author":"MJ Kane","year":"2012","journal-title":"J Neurosci Methods"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/neu.2011.2123","article-title":"Repeated mild lateral fluid percussion brain injury in the rat causes cumulative long-term behavioral impairments, neuroinflammation, and cortical loss in an animal model of repeated concussion","volume":"29","author":"SR Shultz","year":"2012","journal-title":"J Neurotrauma"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1089\/neu.2005.22.1003","article-title":"Mild Traumatic Brain Injury Induces Persistent Cognitive Deficits and Behavioral Disturbances in Mice","volume":"22","author":"A Milman","year":"2005","journal-title":"J Neurotrauma"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.euroneuro.2007.05.007","article-title":"DHEAS repeated treatment improves cognitive and behavioral deficits after mild traumatic brain injury","volume":"18","author":"A Milman","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2009.06.067","article-title":"Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits","volume":"1287","author":"S Yu","year":"2009","journal-title":"Brain Res"},{"key":"ref49","first-page":"1","article-title":"A study of the rat\u2019s behavior in a field: A contribution to method in comparative psychology","volume":"6","author":"C Hall","year":"1932","journal-title":"Univ Calif Publ Psychol"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.expneurol.2010.09.017","article-title":"Characterization of the Brain Injury, Neurobehavioral Profiles and Histopathology in a Rat Model of Cerebellar Hemorrhage","volume":"227","author":"T Lekic","year":"2011","journal-title":"Exp Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/neu.1996.13.293","article-title":"The effects of amphetamine on recovery of function after cortical damage in the rat depend on the behavioral requirements of the task","volume":"13","author":"T Schmanke","year":"1996","journal-title":"J Neurotrauma"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00537801","article-title":"A rotarod suitable for quantitative measurements of motor incoordination in naive mice","volume":"259","author":"B Jones","year":"1968","journal-title":"Naunyn Schmiedebergs Arch Exp Patholohy Pharmakologie"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neubiorev.2004.06.002","article-title":"Motor and cognitive function evaluation following experimental traumatic brain injury","volume":"28","author":"ST Fujimoto","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF02244871","article-title":"Behavioral and pharmacological characterization of the elevated \u201czero-maze\u201d as an animal model of anxiety","volume":"116","author":"J Shepherd","year":"1994","journal-title":"Psychopharmacology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"940830","DOI":"10.1155\/2013\/940830","article-title":"Pomegranate supplementation improves affective and motor behavior in mice after radiation exposure","volume":"2013","author":"MS Dulcich","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"ref56","first-page":"327","article-title":"Behavior despair in mice: A primary screening test for antidepressants","volume":"229","author":"R Porsolt","year":"1997","journal-title":"Arch Int Pharmacodyn th\u00e9rapie"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nbd.2006.08.006","article-title":"Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer\u2019s disease","volume":"24","author":"RE Hartman","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"R Morris","year":"1984","journal-title":"J Neurosci Methods"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2009.07.007","article-title":"Social features of scent-donor mice modulate scent marking of C57BL\/6J recipient males","volume":"205","author":"H Arakawa","year":"2009","journal-title":"Behav Brain Res"},{"issue":"7","key":"ref60","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/neu.2006.0211","article-title":"Multi-modal magnetic resonance imaging alterations in two rat models of mild neurotrauma","volume":"24","author":"A Obenaus","year":"2007","journal-title":"J Neurotrauma"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainres.2012.12.038","article-title":"Tissue vulnerability is increased following repetitive mild traumatic brain injury in the rat","volume":"1499","author":"L Huang","year":"2013","journal-title":"Brain Res"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1089\/neu.1997.14.615","article-title":"Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact","volume":"14","author":"SW Scheff","year":"1997","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"e53529","DOI":"10.1371\/journal.pone.0053529","article-title":"The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E","volume":"8","author":"DR Namjoshi","year":"2013","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3171\/2014.7.JNS14272","article-title":"Chronic gliosis and behavioral deficits in mice following repetitive mild traumatic brain injury","volume":"121","author":"R Mannix","year":"2014","journal-title":"J Neurosurg"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1038\/srep11178","article-title":"Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model","volume":"5","author":"Z Yang","year":"2015","journal-title":"Sci Rep"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.neubiorev.2008.05.012","article-title":"Scent marking behavior as an odorant communication in mice","volume":"32","author":"H Arakawa","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"issue":"17","key":"ref67","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1089\/neu.2012.2595","article-title":"Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice","volume":"29","author":"BD Semple","year":"2012","journal-title":"J Neurotrauma"},{"issue":"2","key":"ref68","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.bbr.2009.07.027","article-title":"Depression-like and anxiety-like behavioural aftermaths of impact accelerated traumatic brain injury in rats: a model of comorbid depression and anxiety?","volume":"205","author":"DK Pandey","year":"2009","journal-title":"Behav Brain Res"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11682-012-9173-4","article-title":"Functional MRI of mild traumatic brain injury (mTBI): progress and perspectives from the first decade of studies","volume":"6","author":"BC McDonald","year":"2012","journal-title":"Brain Imaging Behav"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.expneurol.2010.09.015","article-title":"Physiological and histopathological responses following closed rotational head injury depend on direction of head motion","volume":"227","author":"SA Eucker","year":"2011","journal-title":"Exp Neurol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/msj.20104","article-title":"Pathophysiology of Traumatic Brain Injury","volume":"76","author":"MW Greve","year":"2009","journal-title":"Mt Sinai J Med"},{"key":"ref72","article-title":"Brain Neurotrauma: Molecular, Neurophysical, and Rehabilitation Aspects","author":"RA Laskowski","year":"2015"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1017\/S1355617714000812","article-title":"Disrupted structural connectome is associated with both psychometric and real-world neuropsychological impairment in diffuse traumatic brain injury","volume":"20","author":"J Kim","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ncl.2006.03.003","article-title":"Cytokine, sickness behavior, and depression","volume":"24","author":"R Dantzer","year":"2006","journal-title":"NeuroImage Clin"},{"issue":"5","key":"ref75","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Y Dowlati","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbr.2011.12.015","article-title":"Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments","volume":"229","author":"SR Shultz","year":"2012","journal-title":"Behav Brain Res"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2006.03.011","article-title":"Role of IL-1 in poststroke depressive-like behavior in mice","volume":"60","author":"TKS Craft","year":"2006","journal-title":"Biol Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0146886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T22:15:08Z","timestamp":1567548908000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0146886"}},"subtitle":[],"editor":[{"given":"Kimberly R.","family":"Byrnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0146886","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]}}}