{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:59:29Z","timestamp":1787021969163,"version":"build-2736575974"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0146951","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T15:52:00Z","timestamp":1453305120000},"page":"e0146951","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["In silico Identification and Validation of a Linear and Naturally Immunogenic B-Cell Epitope of the Plasmodium vivax Malaria Vaccine Candidate Merozoite Surface Protein-9"],"prefix":"10.1371","volume":"11","author":[{"given":"Rodrigo Nunes","family":"Rodrigues-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Herm\u00ednio","family":"Martins da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balwan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda V. S.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalma Maria","family":"Banic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Galinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseli","family":"Oliveira-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9 da Costa","family":"Lima-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,20]]},"reference":[{"key":"ref1","unstructured":"W.H.O. WORLD MALARIA REPORT 2014. 2014."},{"issue":"6872","key":"ref2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/415694a","article-title":"Progress and challenges for malaria vaccines","volume":"415","author":"TL Richie","year":"2002","journal-title":"Nature"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1473-3099(08)70153-1","article-title":"Acute lung injury and other serious complications of Plasmodium vivax malaria","volume":"8","author":"LK Tan","year":"2008","journal-title":"The Lancet Infectious diseases"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.2007.77.79","article-title":"Vivax malaria: neglected and not benign","volume":"77","author":"RN Price","year":"2007","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1475-2875-13-481","article-title":"Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900","volume":"13","author":"BA Rahimi","year":"2014","journal-title":"Malaria journal"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/1475-2875-13-404","article-title":"A descriptive study of 16 severe Plasmodium vivax cases from three municipalities of Colombia between 2009 and 2013","volume":"13","author":"AT O'Brien","year":"2014","journal-title":"Malaria journal"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1089\/vbz.2012.1192","article-title":"Severe Plasmodium vivax malaria complicated with acute respiratory distress syndrome: a case associated with focal autochthonous transmission in Greece","volume":"14","author":"A Gougoutsi","year":"2014","journal-title":"Vector borne and zoonotic diseases"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3201\/eid1911.130495","article-title":"Severe Plasmodium vivax malaria in Pakistan","volume":"19","author":"AB Zubairi","year":"2013","journal-title":"Emerging infectious diseases"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S1473-3099(14)70855-2","article-title":"Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis","volume":"14","author":"RN Price","year":"2014","journal-title":"The Lancet Infectious diseases"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3201\/eid1307.061386","article-title":"Chloroquine-resistant Plasmodium vivax, Brazilian Amazon","volume":"13","author":"FS de Santana Filho","year":"2007","journal-title":"Emerging infectious diseases"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4269\/ajtmh.2003.69.548","article-title":"Chloroquine-resistant Plasmodium vivax malaria in Peru","volume":"69","author":"TK Ruebush 2nd","year":"2003","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2307\/3284254","article-title":"Studies on a primaquine-tolerant strain of Plasmodium vivax from Brazil in Aotus and Saimiri monkeys","volume":"83","author":"JK Nayar","year":"1997","journal-title":"The Journal of parasitology"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/00365548.2013.822093","article-title":"Recurrent Plasmodium vivax malaria due to dose-dependent primaquine resistance: a case report","volume":"46","author":"KL Kristensen","year":"2014","journal-title":"Scandinavian journal of infectious diseases"},{"issue":"1","key":"ref14","first-page":"21","article-title":"Low response of Colombian strains of Plasmodium vivax to classical antimalarial therapy","volume":"40","author":"AE Arias","year":"1989","journal-title":"Tropical medicine and parasitology: official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit"},{"key":"ref15","unstructured":"Organization WH. Tables of malaria vaccine projects globally (&quot;Rainbow Tables&quot;). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/immunization\/research\/development\/Rainbow_tables\/en\/2015\" xlink:type=\"simple\">http:\/\/www.who.int\/immunization\/research\/development\/Rainbow_tables\/en\/2015<\/ext-link>. Accessed 20 July 2015."},{"issue":"13\u201314","key":"ref16","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.ijpara.2004.10.009","article-title":"Use of long synthetic peptides to study the antigenicity and immunogenicity of the Plasmodium vivax circumsporozoite protein","volume":"34","author":"S Herrera","year":"2004","journal-title":"International journal for parasitology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4269\/ajtmh.2005.73.3","article-title":"Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivax circumsporozoite protein-derived synthetic vaccine","volume":"73","author":"S Herrera","year":"2005","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"13","key":"ref18","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.micinf.2005.04.020","article-title":"Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria","volume":"7","author":"I Caro-Aguilar","year":"2005","journal-title":"Microbes and infection \/ Institut Pasteur"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-2875-11-11","article-title":"A review of malaria vaccine clinical projects based on the WHO rainbow table","volume":"11","author":"L Schwartz","year":"2012","journal-title":"Malaria journal"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pt.2003.12.003","article-title":"Vaccination for vivax malaria: targeting the invaders","volume":"20","author":"SD Polley","year":"2004","journal-title":"Trends in parasitology"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1440-1711.2002.01107.x","article-title":"Immunity to asexual blood stage malaria and vaccine approaches","volume":"80","author":"J Wipasa","year":"2002","journal-title":"Immunology and cell biology"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1904s93","article-title":"Experimental asexual blood stage malaria immunity","author":"FH Amante","year":"2011","journal-title":"Current protocols in immunology"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pt.2007.01.008","article-title":"An update on the search for a Plasmodium vivax vaccine","volume":"23","author":"S Herrera","year":"2007","journal-title":"Trends in parasitology"},{"issue":"Pt 21","key":"ref24","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1242\/jeb.00646","article-title":"Progress in the development of recombinant and synthetic blood-stage malaria vaccines","volume":"206","author":"S Mahanty","year":"2003","journal-title":"The Journal of experimental biology"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.vaccine.2010.12.099","article-title":"B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3alpha (PvMSP-3alpha) in malaria exposed individuals from Brazilian Amazon","volume":"29","author":"JC Lima-Junior","year":"2011","journal-title":"Vaccine"},{"issue":"51","key":"ref26","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1016\/j.vaccine.2008.09.029","article-title":"Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals","volume":"26","author":"JC Lima-Junior","year":"2008","journal-title":"Vaccine"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4269\/ajtmh.2011.10-0044","article-title":"Evaluation of the naturally acquired antibody immune response to the Pv200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil","volume":"84","author":"LM Storti-Melo","year":"2011","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/expr.1998.4372","article-title":"Plasmodium vivax, P. cynomolgi, and P. knowlesi: identification of homologue proteins associated with the surface of merozoites","volume":"91","author":"JW Barnwell","year":"1999","journal-title":"Experimental parasitology"},{"issue":"247","key":"ref29","doi-asserted-by":"crossref","first-page":"247ra102","DOI":"10.1126\/scitranslmed.3008705","article-title":"New antigens for a multicomponent blood-stage malaria vaccine","volume":"6","author":"FH Osier","year":"2014","journal-title":"Science translational medicine"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00436-014-3907-8","article-title":"Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10","volume":"113","author":"Y Cheng","year":"2014","journal-title":"Parasitology research"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"e2498","DOI":"10.1371\/journal.pntd.0002498","article-title":"Naturally acquired immune responses to P. vivax merozoite surface protein 3alpha and merozoite surface protein 9 are associated with reduced risk of P. vivax malaria in young Papua New Guinean children","volume":"7","author":"DI Stanisic","year":"2013","journal-title":"PLoS neglected tropical diseases"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1567-1348(03)00007-8","article-title":"Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi","volume":"3","author":"E Vargas-Serrato","year":"2003","journal-title":"Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.vaccine.2007.12.042","article-title":"Plasmodium berghei merozoite surface protein-9: immunogenicity and protective efficacy using a homologous challenge model","volume":"26","author":"TM Lopera-Mesa","year":"2008","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.meegid.2013.09.011","article-title":"The evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (MSP-9), in Plasmodium vivax and closely related species","volume":"20","author":"SM Chenet","year":"2013","journal-title":"Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0166-6851(01)00433-9","article-title":"Merozoite surface protein-9 of Plasmodium vivax and related simian malaria parasites is orthologous to p101\/ABRA of P. falciparum","volume":"120","author":"E Vargas-Serrato","year":"2002","journal-title":"Molecular and biochemical parasitology"},{"issue":"15\u201316","key":"ref36","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.vaccine.2003.07.021","article-title":"Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli","volume":"22","author":"J Oliveira-Ferreira","year":"2004","journal-title":"Vaccine"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"e36419","DOI":"10.1371\/journal.pone.0036419","article-title":"Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3alpha and MSP-9 in individuals from Brazilian endemic area","volume":"7","author":"JC Lima-Junior","year":"2012","journal-title":"PloS one"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"JE Larsen","year":"2006","journal-title":"Immunome research"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.immuni.2010.09.017","article-title":"Reverse vaccinology: developing vaccines in the era of genomics","volume":"33","author":"A Sette","year":"2010","journal-title":"Immunity"},{"issue":"16","key":"ref40","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1093\/bioinformatics\/bti541","article-title":"IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content","volume":"21","author":"Z Dosztanyi","year":"2005","journal-title":"Bioinformatics"},{"issue":"20","key":"ref41","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1093\/bioinformatics\/btp518","article-title":"ANCHOR: web server for predicting protein binding regions in disordered proteins","volume":"25","author":"Z Dosztanyi","year":"2009","journal-title":"Bioinformatics"},{"issue":"Suppl 9","key":"ref42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/prot.22540","article-title":"Structure prediction for CASP8 with all-atom refinement using Rosetta","volume":"77","author":"S Raman","year":"2009","journal-title":"Proteins"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"Journal of molecular biology"},{"issue":"17","key":"ref44","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic acids research"},{"issue":"D1","key":"ref45","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkt1223","article-title":"Pfam: the protein families database","volume":"42","author":"RD Finn","year":"2014","journal-title":"Nucleic acids research"},{"issue":"18","key":"ref46","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: Application to microtubules and the ribosome","volume":"98","author":"NA Baker","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref47","unstructured":"Schrodinger, LLC. The PyMOL Molecular Graphics System, Version 1.7.4. 2010."},{"issue":"16","key":"ref48","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: Fast, flexible, and free","volume":"26","author":"D Van Der Spoel","year":"2005","journal-title":"Journal of Computational Chemistry"},{"issue":"13","key":"ref49","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jcc.20090","article-title":"A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6","volume":"25","author":"C Oostenbrink","year":"2004","journal-title":"J Comput Chem"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Berendsen HJC, Postma JPM, Gunsteren WF, Hermans J. Interaction Models for Water in Relation to Protein Hydration. In: Pullman B, editor. Intermolecular Forces. The Jerusalem Symposia on Quantum Chemistry and Biochemistry. 14: Springer Netherlands; 1981. p. 331\u201342.","DOI":"10.1007\/978-94-015-7658-1_21"},{"issue":"6","key":"ref51","first-page":"315","article-title":"Automated multiple peptide synthesis","volume":"5","author":"H Gausepohl","year":"1992","journal-title":"Peptide research"},{"key":"ref52","unstructured":"SVS-SIVEP-Mal\u00e1ria MdS-. Sistema de Informa\u00e7\u00e3o de Vigil\u00e2ncia Epidemiol\u00f3gica\u2014Notifica\u00e7\u00e3o de casos. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/portalweb04.saude.gov.br\/sivep_malaria\/default.asp2015\" xlink:type=\"simple\">http:\/\/portalweb04.saude.gov.br\/sivep_malaria\/default.asp2015<\/ext-link>. Accessed 30 July 2015."},{"key":"ref53","doi-asserted-by":"crossref","first-page":"W500","DOI":"10.1093\/nar\/gkh429","article-title":"STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins","volume":"32","author":"M Heinig","year":"2004","journal-title":"Nucleic acids research"},{"issue":"42","key":"ref54","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/j.vaccine.2013.05.082","article-title":"Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein","volume":"31","author":"N Cespedes","year":"2013","journal-title":"Vaccine"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.micinf.2008.10.009","article-title":"Recombinant peptide replicates immunogenicity of synthetic linear peptide chimera for use as pre-erythrocytic stage malaria vaccine","volume":"11","author":"LM Silva-Flannery","year":"2009","journal-title":"Microbes and infection \/ Institut Pasteur"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"671050","DOI":"10.1155\/2014\/671050","article-title":"Genetic diversity of MSP1 Block 2 of Plasmodium vivax isolates from Manaus (central Brazilian Amazon)","volume":"2014","author":"LA Soares","year":"2014","journal-title":"Journal of immunology research"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"e21289","DOI":"10.1371\/journal.pone.0021289","article-title":"Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1)","volume":"6","author":"LL Bueno","year":"2011","journal-title":"PloS one"},{"issue":"18","key":"ref58","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1016\/j.vaccine.2010.02.046","article-title":"Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN-gamma and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon","volume":"28","author":"JC Lima","year":"2010","journal-title":"Vaccine"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jmb.2008.03.039","article-title":"Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2","volume":"379","author":"X Zhang","year":"2008","journal-title":"Journal of molecular biology"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molbiopara.2009.03.012","article-title":"Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils","volume":"166","author":"CG Adda","year":"2009","journal-title":"Molecular and biochemical parasitology"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.molbiopara.2006.08.011","article-title":"Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes","volume":"150","author":"ZP Feng","year":"2006","journal-title":"Molecular and biochemical parasitology"},{"issue":"5720","key":"ref62","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.1107449","article-title":"Crystal structure of the malaria vaccine candidate apical membrane antigen 1","volume":"308","author":"JC Pizarro","year":"2005","journal-title":"Science"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0022-2836(02)00806-9","article-title":"Structure of domain III of the blood-stage malaria vaccine candidate, <italic>Plasmodium falciparum<\/italic> apical membrane antigen 1 (AMA1)","volume":"322","author":"M Nair","year":"2002","journal-title":"J Mol Biol"},{"issue":"7","key":"ref64","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1074\/jbc.M308716200","article-title":"A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3","volume":"279","author":"X Li","year":"2004","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/IAI.73.2.1235-1238.2005","article-title":"Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing","volume":"73","author":"S Singh","year":"2005","journal-title":"Infection and immunity"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1086\/423208","article-title":"Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design","volume":"190","author":"S Singh","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4269\/ajtmh.1999.60.135","article-title":"Differential effect and interaction of monocytes, hyperimmune sera, and immunoglobulin G on the growth of asexual stage Plasmodium falciparum parasites","volume":"60","author":"YP Shi","year":"1999","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"4","key":"ref68","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/IAI.60.4.1473-1481.1992","article-title":"Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity","volume":"60","author":"H Bouharoun-Tayoun","year":"1992","journal-title":"Infection and immunity"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/expr.2001.4619","article-title":"Plasmodium falciparum: a major role for IgG3 in antibody-dependent monocyte-mediated cellular inhibition of parasite growth in vitro","volume":"98","author":"AE Tebo","year":"2001","journal-title":"Experimental parasitology"},{"issue":"15","key":"ref70","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1016\/j.vaccine.2006.06.081","article-title":"Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial","volume":"25","author":"CC Hermsen","year":"2007","journal-title":"Vaccine"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0923-2494(90)90021-P","article-title":"Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: functional role of IgG subclasses","volume":"141","author":"H Groux","year":"1990","journal-title":"Research in immunology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1475-2875-9-29","article-title":"Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay","volume":"9","author":"C Fernandez-Becerra","year":"2010","journal-title":"Malaria journal"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1128\/IAI.74.5.2726-2733.2006","article-title":"A reduced risk of infection with Plasmodium vivax and clinical protection against malaria are associated with antibodies against the N terminus but not the C terminus of merozoite surface protein 1","volume":"74","author":"PA Nogueira","year":"2006","journal-title":"Infection and immunity"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/1475-2875-12-294","article-title":"High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms","volume":"12","author":"FG Versiani","year":"2013","journal-title":"Malaria journal"},{"issue":"26","key":"ref75","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/j.vaccine.2014.04.007","article-title":"Antigenicity and immunogenicity of a novel Plasmodium vivax circumsporozoite derived synthetic vaccine construct","volume":"32","author":"N Cespedes","year":"2014","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0146951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T01:35:28Z","timestamp":1600047328000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0146951"}},"subtitle":[],"editor":[{"given":"\u00c9rika Martins","family":"Braga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,20]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0146951","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,20]]}}}