{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:53:07Z","timestamp":1791337987446,"version":"4.3.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0147171","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T19:27:40Z","timestamp":1453404460000},"page":"e0147171","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning"],"prefix":"10.1371","volume":"11","author":[{"given":"Ilkka","family":"Pietil\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Prunskaite-Hyyryl\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Kaisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Tika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertien M.","family":"van Eerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti M.","family":"Salo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Garma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Miinalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wout F.","family":"Feitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernie M. H. F.","family":"Bongers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Juffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nine V. A. M.","family":"Knoers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten Y.","family":"Renkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Myllyharju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo J.","family":"Vainio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00404-001-0265-4","article-title":"Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990\u20131998)","volume":"266","author":"A Queisser-Luft","year":"2002","journal-title":"Arch Gynecol Obstet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s00467-003-1158-5","article-title":"Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS","volume":"18","author":"MG Seikaly","year":"2003","journal-title":"Pediatr Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.devcel.2010.04.008","article-title":"Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development","volume":"18","author":"F Costantini","year":"2010","journal-title":"Dev Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000360659","article-title":"Kidney development: an overview","volume":"126","author":"I Pietila","year":"2014","journal-title":"Nephron Exp Nephrol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2014.08.014","article-title":"Induction and patterning of the metanephric nephron","volume":"36","author":"LL O'Brien","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4161\/org.5.4.10048","article-title":"The many faces of RET dysfunction in kidney","volume":"5","author":"S Jain","year":"2009","journal-title":"Organogenesis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/jcs.00786","article-title":"Novel functions and signalling pathways for GDNF","volume":"116","author":"H Sariola","year":"2003","journal-title":"J Cell Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1242\/dev.122.11.3627","article-title":"Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips","volume":"122","author":"A Kispert","year":"1996","journal-title":"Development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/372679a0","article-title":"Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4","volume":"372","author":"K Stark","year":"1994","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1242\/dev.125.21.4225","article-title":"Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney","volume":"125","author":"A Kispert","year":"1998","journal-title":"Development"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/gene.10079","article-title":"Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro","volume":"32","author":"P Itaranta","year":"2002","journal-title":"Genesis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"TJ Carroll","year":"2005","journal-title":"Dev Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/dvdy.1164","article-title":"Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis","volume":"222","author":"Y Lin","year":"2001","journal-title":"Dev Dyn"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/dev.022087","article-title":"A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney","volume":"136","author":"J Yu","year":"2009","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000368411","article-title":"Wnt5a is necessary for normal kidney development in zebrafish and mice","volume":"128","author":"L Huang","year":"2014","journal-title":"Nephron Exp Nephrol"},{"key":"ref16","article-title":"Non-canonical Wnt5a\/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension","author":"K Yun","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1128\/MCB.00491-14","article-title":"Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding","volume":"34","author":"M Nishita","year":"2014","journal-title":"Mol Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1242\/jcs.163683","article-title":"Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation","volume":"128","author":"H Yamamoto","year":"2015","journal-title":"J Cell Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e19453","DOI":"10.1371\/journal.pone.0019453","article-title":"Two distinct integrin-mediated mechanisms contribute to apical lumen formation in epithelial cells","volume":"6","author":"SM Myllymaki","year":"2011","journal-title":"PLoS One"},{"key":"ref20","article-title":"Interactions of DPP-4 and integrin beta1 influences endothelial-to-mesenchymal transition","author":"S Shi","year":"2015","journal-title":"Kidney Int"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4161\/org.7.2.15275","article-title":"Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane","volume":"7","author":"JH Miner","year":"2011","journal-title":"Organogenesis"},{"key":"ref22","article-title":"The Wnt\/beta-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target","volume":"3","author":"MV Enzo","year":"2015","journal-title":"Mol Cell Ther"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pbio.0040115","article-title":"Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context","volume":"4","author":"AJ Mikels","year":"2006","journal-title":"PLoS Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1242\/dev.126.6.1211","article-title":"A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo","volume":"126","author":"TP Yamaguchi","year":"1999","journal-title":"Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1074\/jbc.M606608200","article-title":"Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice","volume":"282","author":"T Holster","year":"2007","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0925-4773(01)00526-3","article-title":"Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis","volume":"109","author":"S Zhang","year":"2001","journal-title":"Mech Dev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nmeth985","article-title":"Tomographic molecular imaging and 3D quantification within adult mouse organs","volume":"4","author":"T Alanentalo","year":"2007","journal-title":"Nat Methods"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e27676","DOI":"10.1371\/journal.pone.0027676","article-title":"A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development","volume":"6","author":"L Chi","year":"2011","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.yexcr.2008.04.010","article-title":"Wnt-11 signaling leads to down-regulation of the Wnt\/beta-catenin, JNK\/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells","volume":"314","author":"A Railo","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0945-053X(98)90009-9","article-title":"Prolyl 4-hydroxylases and their protein disulfide isomerase subunit","volume":"16","author":"KI Kivirikko","year":"1998","journal-title":"Matrix Biol"},{"issue":"Pt A","key":"ref31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0076-6879(82)82067-3","article-title":"Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes","volume":"82","author":"KI Kivirikko","year":"1982","journal-title":"Methods Enzymol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"A Roy","year":"2010","journal-title":"Nat Protoc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.1222879","article-title":"Structural basis of Wnt recognition by Frizzled","volume":"337","author":"CY Janda","year":"2012","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jcc.20090","article-title":"A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6","volume":"25","author":"C Oostenbrink","year":"2004","journal-title":"J Comput Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1242\/dev.071266","article-title":"Renal collecting system growth and function depend upon embryonic gamma1 laminin expression","volume":"138","author":"DH Yang","year":"2011","journal-title":"Development"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1074\/jbc.M606608200","article-title":"Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice","volume":"282","author":"T Holster","year":"2007","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrneph.2010.68","article-title":"Cardiovascular risk in the peritoneal dialysis patient","volume":"6","author":"RT Krediet","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.144.1.151","article-title":"Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation","volume":"144","author":"N Smyth","year":"1999","journal-title":"J Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0147171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T03:43:50Z","timestamp":1654141430000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0147171"}},"subtitle":[],"editor":[{"given":"Shree Ram","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,21]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0147171","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,21]]}}}