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Long","year":"2001","journal-title":"Health Policy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.soc.27.1.363","article-title":"Conceptualizing stigma","volume":"27","author":"B Link","year":"2001","journal-title":"Annu Rev Sociol"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.5588\/ijtld.11.0713","article-title":"Integrated, Home-based Treatment for MDR-TB and HIV in Rural South Africa: An Alternate Model of Care","volume":"16","author":"JCM Brust","year":"2012","journal-title":"Int J Tubercu Lung Dis"},{"issue":"12","key":"ref32","first-page":"e1","article-title":"A home-based approach to managing multi-drug resistant tuberculosis in Uganda: a case report","volume":"9","author":"L Emmanual","year":"2012","journal-title":"AIDS Research and Therapy"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/thoraxjnl-2011-200018","article-title":"Factors contributing to the high prevalence of multidrug-resistant tuberculosis: a study from China","volume":"67","author":"Libo Liang","year":"2012","journal-title":"Thorax"},{"key":"ref34","unstructured":"TB Alliance. 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World Health Organization Commission on Social Determinants of Health\u2014Measurement and Evidence Knowledge Network. 2006; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/social_determinants\/resources\/mekn_paper.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/social_determinants\/resources\/mekn_paper.pdf<\/ext-link>"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2471\/BLT.12.104588","article-title":"Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors","volume":"91","author":"A Skrahina","year":"2013","journal-title":"Bull World Health Organ"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.5588\/ijtld.12.0026","article-title":"Alcohol use and abuse among patients with multidrug-resistant tuberculosis in Botswana","volume":"16","author":"NN Zetola","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1513\/AnnalsATS.201312-447OC","article-title":"Does Alcohol Consumption during Multidrug-resistant Tuberculosis Treatment Affect Outcome? 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