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craniofacial abnormalities in mice deficient in endothelin-1","volume":"368","author":"Y Kurihara","year":"1994","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/dev.125.5.813","article-title":"Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice","volume":"125","author":"DE Clouthier","year":"1998","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1242\/dev.125.5.825","article-title":"Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene","volume":"125","author":"H Yanagisawa","year":"1998","journal-title":"Development"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1242\/dev.01291","article-title":"Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity","volume":"131","author":"LB Ruest","year":"2004","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ydbio.2009.01.005","article-title":"Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism","volume":"328","author":"LB Ruest","year":"2009","journal-title":"Dev Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0012-1606(02)00097-0","article-title":"Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme","volume":"255","author":"K Ivey","year":"2003","journal-title":"Dev Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ydbio.2005.03.006","article-title":"Characteristic defects in neural crest cell-specific Galphaq\/Galpha11- and Galpha12\/Galpha13-deficient mice","volume":"282","author":"DA 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Ubiquitin\/proteasome-dependent regulation","volume":"274","author":"Y Tintut","year":"1999","journal-title":"J Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein","volume":"273","author":"A Vortkamp","year":"1996","journal-title":"Science"},{"key":"ref69","unstructured":"Nanes M, Boden S, Weinstein L (1995) Oligonucleotides antisense to Gs\u03b1 promote osteoblast differentiation; 1995. pp. 62."},{"key":"ref70","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"AC Karaplis","year":"1994","journal-title":"Genes Dev"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.273.5275.663","article-title":"PTH\/PTHrP receptor in early development and Indian hedgehog-regulated bone growth","volume":"273","author":"B Lanske","year":"1996","journal-title":"Science"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1172\/JCI2918","article-title":"Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia","volume":"102","author":"AS Jobert","year":"1998","journal-title":"J Clin Invest"},{"key":"ref73","unstructured":"Chung U, Wei W, Schipani E, Hunzelman J, Weinstein L, et al. (2000) In vivo function of stimulatory G protein (Gs) in the growth plate; 2000. AMER SOC BONE &amp; MINERAL RES 2025 M ST, NW, STE 800, WASHINGTON, DC 20036\u20133309 USA. pp. S175-S175."},{"key":"ref74","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1074\/jbc.M004990200","article-title":"Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone","volume":"276","author":"X Zhen","year":"2001","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1172\/JCI0214817","article-title":"Parathyroid hormone is essential for normal fetal bone formation","volume":"109","author":"D Miao","year":"2002","journal-title":"J Clin Invest"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1210\/en.2003-1097","article-title":"Skeletal abnormalities in Pth-null mice are influenced by dietary calcium","volume":"145","author":"D Miao","year":"2004","journal-title":"Endocrinology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e20780","DOI":"10.1371\/journal.pone.0020780","article-title":"Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts","volume":"6","author":"R Zhang","year":"2011","journal-title":"PLoS One"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"20101","DOI":"10.1073\/pnas.1114656108","article-title":"Wnt\/beta-catenin signaling is differentially regulated by Galpha proteins and contributes to fibrous dysplasia","volume":"108","author":"JB Regard","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"V Brault","year":"2001","journal-title":"Development"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5115\/acb.2012.45.3.193","article-title":"Col1a1-cre mediated activation of beta-catenin leads to aberrant dento-alveolar complex formation","volume":"45","author":"TH Kim","year":"2012","journal-title":"Anat Cell Biol"},{"key":"ref81","author":"B Hogan","year":"1986"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1242\/dev.119.2.319","article-title":"Two rhombomeres are altered in Hoxa-1 mutant mice","volume":"119","author":"M Mark","year":"1993","journal-title":"Development"},{"key":"ref83","first-page":"345","article-title":"Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion","volume":"39","author":"CL Brunet","year":"1995","journal-title":"Int J Dev Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1242\/dev.126.17.3869","article-title":"Pathogenesis of cleft palate in TGF-beta3 knockout mice","volume":"126","author":"Y Taya","year":"1999","journal-title":"Development"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1242\/dev.00708","article-title":"Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects","volume":"130","author":"Y Ito","year":"2003","journal-title":"Development"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1074\/jbc.M109.035105","article-title":"Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells","volume":"285","author":"J Iwata","year":"2010","journal-title":"J Biol Chem"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"24898","DOI":"10.1074\/jbc.M114.570507","article-title":"Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2\/Smads interactions","volume":"289","author":"K Amano","year":"2014","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0147535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T20:07:45Z","timestamp":1654286865000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0147535"}},"subtitle":[],"editor":[{"given":"James","family":"Cray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":87,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0147535","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}