{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:04:30Z","timestamp":1778857470666,"version":"3.51.4"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0147548","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T14:34:07Z","timestamp":1453732447000},"page":"e0147548","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Analysis of Substrate-Free Cultured Oral Mucosal Epithelial Cell Sheets from Cells of Subjects with and without Stevens\u2014Johnson Syndrome for Use in Ocular Surface Reconstruction"],"prefix":"10.1371","volume":"11","author":[{"given":"Yun Hee","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Ryang","family":"Wee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saewha","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee Kum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"issue":"9057","key":"ref1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0140-6736(96)11188-0","article-title":"Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium","volume":"349","author":"G Pellegrini","year":"1997","journal-title":"Lancet"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/jcb.23028","article-title":"13 years of cultured limbal epithelial cell therapy: a review of the outcomes","volume":"112","author":"O Baylis","year":"2011","journal-title":"J Cell Biochem"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1167\/iovs.11-7847","article-title":"Transplantation of cultivated oral mucosal epithelium prepared in fibrin-coated culture dishes","volume":"53","author":"M Hirayama","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ICU.0b013e3283477d4d","article-title":"New hopes and strategies for the treatment of severe ocular surface disease","volume":"22","author":"T Nakamura","year":"2011","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00003226-200301000-00017","article-title":"Successful regrafting of cultivated corneal epithelium using amniotic membrane as a carrier in severe ocular surface disease","volume":"22","author":"T Nakamura","year":"2003","journal-title":"Cornea"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1056\/NEJMoa040455","article-title":"Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium","volume":"351","author":"K Nishida","year":"2004","journal-title":"N Engl J Med"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.ophtha.2006.09.034","article-title":"Phenotypic investigation of human eyes with transplanted autologous cultivated oral mucosal epithelial sheets for severe ocular surface diseases","volume":"114","author":"T Nakamura","year":"2007","journal-title":"Ophthalmology"},{"key":"ref8","first-page":"422","article-title":"Culture &amp; characterisation of limbal epithelial cells &amp; oral mucosal cells","volume":"131","author":"S Krishnan","year":"2010","journal-title":"Indian J Med Res"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ophtha.2008.12.048","article-title":"Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications","volume":"116","author":"C Sotozono","year":"2009","journal-title":"Ophthalmology"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ajo.2012.03.044","article-title":"The relation between visual performance and clinical ocular manifestations in Stevens-Johnson syndrome","volume":"154","author":"M Kaido","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5966\/sctm.2011-0037","article-title":"Concise review: limbal stem cell deficiency, dysfunction, and distress","volume":"1","author":"S Ahmad","year":"2012","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ophtha.2012.07.053","article-title":"Visual improvement after cultivated oral mucosal epithelial transplantation","volume":"120","author":"C Sotozono","year":"2013","journal-title":"Ophthalmology"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/bjophthalmol-2013-304645","article-title":"Upregulation of Toll-like receptor 5 expression in the conjunctival epithelium of various human ocular surface diseases","volume":"98","author":"K Yamada","year":"2014","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ophtha.2014.08.013","article-title":"The role of systemic immunomodulatory treatment and prognostic factors on chronic ocular complications in Stevens-Johnson syndrome","volume":"122","author":"DH Kim","year":"2015","journal-title":"Ophthalmology"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3346\/jkms.2008.23.5.864","article-title":"Efficient cultivation conditions for human limbal epithelial cells","volume":"23","author":"MK Kim","year":"2008","journal-title":"J Korean Med Sci"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1073\/pnas.84.8.2302","article-title":"Three clonal types of keratinocyte with different capacities for multiplication","volume":"84","author":"Y Barrandon","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0092-8674(94)90383-2","article-title":"Location of stem cells of human hair follicles by clonal analysis","volume":"76","author":"A Rochat","year":"1994","journal-title":"Cell"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0092-8674(75)90183-X","article-title":"Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma","volume":"6","author":"JG Rheinwald","year":"1975","journal-title":"Cell"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(75)80001-8","article-title":"Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells","volume":"6","author":"JG Rheinwald","year":"1975","journal-title":"Cell"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0092-8674(87)90179-6","article-title":"Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor","volume":"50","author":"Y Barrandon","year":"1987","journal-title":"Cell"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMoa0905955","article-title":"Limbal stem-cell therapy and long-term corneal regeneration","volume":"363","author":"P Rama","year":"2010","journal-title":"N Engl J Med"},{"issue":"7306","key":"ref22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/466567a","article-title":"Regenerative medicine: An eye to treating blindness","volume":"466","author":"E Ezhkova","year":"2010","journal-title":"Nature"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.ophtha.2011.01.039","article-title":"Long-term outcome of cultivated oral mucosal epithelial sheet transplantation in treatment of total limbal stem cell deficiency","volume":"118","author":"Y Satake","year":"2011","journal-title":"Ophthalmology"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/stem.1517","article-title":"Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine","volume":"32","author":"G Pellegrini","year":"2014","journal-title":"Stem cells (Dayton, Ohio)"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/excr.1999.4564","article-title":"Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes","volume":"251","author":"M Makela","year":"1999","journal-title":"Exp Cell Res"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jcp.21635","article-title":"The epidermal growth factor receptor ligands at a glance","volume":"218","author":"MR Schneider","year":"2009","journal-title":"J Cell Physiol"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/eye.2009.60","article-title":"Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn","volume":"23","author":"DH Ma","year":"2009","journal-title":"Eye (London, England)"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1136\/bjo.2003.038497","article-title":"Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders","volume":"88","author":"T Nakamura","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajo.2005.09.003","article-title":"Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation","volume":"141","author":"T Inatomi","year":"2006","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1167\/iovs.11-9293","article-title":"Expression of angiogenesis-related factors in human corneas after cultivated oral mucosal epithelial transplantation","volume":"53","author":"HC Chen","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0147548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:56:01Z","timestamp":1588964161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0147548"}},"subtitle":[],"editor":[{"given":"Majlinda","family":"Lako","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0147548","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}