{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:37:10Z","timestamp":1792532230550,"version":"4.5.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0147840","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T18:54:14Z","timestamp":1454352854000},"page":"e0147840","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of 3\u2032UTR RET Variants on RET mRNA Secondary Structure and Disease Presentation in Medullary Thyroid Carcinoma"],"prefix":"10.1371","volume":"11","author":[{"given":"Lucieli","family":"Ceolin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Romitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Rodrigues Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Vaz Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Oliboni Scapineli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Assis-Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Vieira Maximiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauanne","family":"Dias Amarante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Celi","family":"de Souza Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1001\/jama.295.18.2164","article-title":"Increasing incidence of thyroid cancer in the United States, 1973\u20132002","volume":"295","author":"L Davies","year":"2006","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/01.mlg.0000168114.90852.a6","article-title":"Prognostic variables and calcitonin in medullary thyroid cancer","volume":"115","author":"JR Clark","year":"2005","journal-title":"Laryngoscope"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ejso.2006.10.021","article-title":"Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients","volume":"33","author":"MR Pelizzo","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"ref4","first-page":"667","article-title":"Diagnosis, treatment, and follow-up of medullary thyroid carcinoma: recommendations by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism","volume":"58","author":"AL Maia","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref5","article-title":"Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma The American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma","author":"SA Wells Jr.","year":"2015","journal-title":"Thyroid"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1091\/mbc.E12-02-0114","article-title":"Alternative splicing results in RET isoforms with distinct trafficking properties","volume":"23","author":"DS Richardson","year":"2012","journal-title":"Mol Biol Cell"},{"key":"ref7","first-page":"2039","article-title":"Characterization of RET proto-oncogene 3&apos; splicing variants and polyadenylation sites: a novel C-terminus for RET","volume":"11","author":"SM Myers","year":"1995","journal-title":"Oncogene"},{"key":"ref8","first-page":"1595","article-title":"The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas","volume":"5","author":"M Santoro","year":"1990","journal-title":"Oncogene"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1210\/jc.2007-1714","article-title":"Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study","volume":"93","author":"R Elisei","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/gcc.2870120308","article-title":"Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma","volume":"12","author":"C Eng","year":"1995","journal-title":"Genes Chromosomes Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2265.1996.681503.x","article-title":"Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinoma","volume":"44","author":"DJ Marsh","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/ijms13010221","article-title":"Molecular Basis of Medullary Thyroid Carcinoma: The Role of RET Polymorphisms","volume":"13","author":"L Ceolin","year":"2012","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/sj.onc.1202418","article-title":"Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation","volume":"18","author":"O Gimm","year":"1999","journal-title":"Oncogene"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1365-2265.2001.01328.x","article-title":"Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population","volume":"55","author":"A Ruiz","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1677\/ERC-09-0312","article-title":"The RET polymorphic allele S836S is associated with early metastatic disease in patients with hereditary or sporadic medullary thyroid carcinoma","volume":"17","author":"DR Siqueira","year":"2010","journal-title":"Endocr Relat Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mrrev.2012.09.002","article-title":"Medullary thyroid carcinoma (MTC) and RET proto-oncogene: mutation spectrum in the familial cases and a meta-analysis of studies on the sporadic form","volume":"752","author":"G Figlioli","year":"2012","journal-title":"Mutat Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.0009-9163.2004.00172.x","article-title":"Germline-sequence variants S836S and L769L in the RE arranged during Transfection (RET) proto-oncogene are not associated with predisposition to sporadic medullary carcinoma in the French population","volume":"65","author":"I Berard","year":"2004","journal-title":"Clin Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12038-011-9095-0","article-title":"RET gene mutations and polymorphisms in medullary thyroid carcinomas in Indian patients","volume":"36","author":"BP Sharma","year":"2011","journal-title":"J Biosci"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.4067\/S0034-98872005000400001","article-title":"Polimorfismos G691S, L769L y S836S del proto-oncogen RET no se asocian a mayor riesgo de c\u00e1ncer medular tiroideo espor\u00e1dico en pacientes chilenos","volume":"133","author":"N Wohllk","year":"2005","journal-title":"Rev M\u00e9d Chile"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/thy.2006.16.411","article-title":"Analysis of RET polymorphisms and haplotypes in the context of sporadic medullary thyroid carcinoma","volume":"16","author":"RM Fernandez","year":"2006","journal-title":"Thyroid"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2265.2008.03491.x","article-title":"Evaluation of RET polymorphisms in a six-generation family with G533C RET mutation: specific RET variants may modulate age at onset and clinical presentation","volume":"71","author":"R Tamanaha","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1530\/EJE-11-1060","article-title":"Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness","volume":"166","author":"L Ceolin","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrn2137","article-title":"Enteric nervous system development and Hirschsprung&apos;s disease: advances in genetic and stem cell studies","volume":"8","author":"TA Heanue","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref24","first-page":"499","article-title":"Identification of mutation of RET proto-oncogene in Hirschsprung disease","volume":"188","author":"T Attie","year":"1994","journal-title":"C R Seances Soc Biol Fil"},{"key":"ref25","first-page":"358","article-title":"Mutations of RET proto-oncogene in Hirschsprung disease","volume":"317","author":"S Lyonnet","year":"1994","journal-title":"C R Acad Sci III"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1440-1827.2006.01942.x","article-title":"RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung&apos;s disease","volume":"56","author":"N Asai","year":"2006","journal-title":"Pathol Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/hmg\/ddg354","article-title":"Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR)","volume":"12","author":"G Fitze","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/humu.20135","article-title":"A common haplotype at the 5&apos; end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression","volume":"25","author":"P Griseri","year":"2005","journal-title":"Hum Mutat"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1529-8817.2005.00196.x","article-title":"Haplotypes of the human RET proto-oncogene associated with Hirschsprung disease in the Italian population derive from a single ancestral combination of alleles","volume":"70","author":"F Lantieri","year":"2006","journal-title":"Ann Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0140-6736(02)08218-1","article-title":"Association between c135G\/A genotype and RET proto-oncogene germline mutations and phenotype of Hirschsprung&apos;s disease","volume":"359","author":"G Fitze","year":"2002","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1086\/342774","article-title":"A rare haplotype of the RET proto-oncogene is a risk-modifying allele in hirschsprung disease","volume":"71","author":"P Griseri","year":"2002","journal-title":"Am J Hum Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/humu.20397","article-title":"A common variant located in the 3&apos;UTR of the RET gene is associated with protection from Hirschsprung disease","volume":"28","author":"P Griseri","year":"2007","journal-title":"Hum Mutat"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1126\/science.1111443","article-title":"From birth to death: the complex lives of eukaryotic mRNAs","volume":"309","author":"MJ Moore","year":"2005","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ssu.10019","article-title":"New TNM staging criteria for head and neck tumors","volume":"21","author":"B O'Sullivan","year":"2003","journal-title":"Semin Surg Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1530\/EJE-14-0084","article-title":"Role of RET genetic variants in MEN2-associated pheochromocytoma","volume":"170","author":"DR Siqueira","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"M Stephens","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/oxfordjournals.jhered.a110358","article-title":"Gametic disequilibrium in cats: epistasis is an unlikely cause","volume":"78","author":"PW Hedrick","year":"1987","journal-title":"J Hered"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA Package 2.0","volume":"6","author":"R Lorenz","year":"2011","journal-title":"Algorithms Mol Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1167\/iovs.12-10660","article-title":"The UCP1 -3826A\/G polymorphism is associated with diabetic retinopathy and increased UCP1 and MnSOD2 gene expression in human retina","volume":"53","author":"LA Brondani","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref40","first-page":"4310","article-title":"Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma","volume":"83","author":"C Eng","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1210\/jc.2003-031898","article-title":"RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population","volume":"89","author":"R Elisei","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/jmg.36.10.771","article-title":"Specific polymorphisms in the RET proto-oncogene are over-represented in patients with Hirschsprung disease and may represent loci modifying phenotypic expression","volume":"36","author":"S Borrego","year":"1999","journal-title":"J Med Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/sj.ejhg.5200521","article-title":"A single-nucleotide polymorphic variant of the RET proto-oncogene is underrepresented in sporadic Hirschsprung disease","volume":"8","author":"P Griseri","year":"2000","journal-title":"Eur J Hum Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/345466","article-title":"A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma","volume":"72","author":"S Borrego","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref45","first-page":"1","article-title":"Aberrant regulation of messenger RNA 3&apos;-untranslated region in human cancer","volume":"29","author":"I Lopez de Silanes","year":"2007","journal-title":"Cell Oncol"},{"key":"ref46","first-page":"1619","article-title":"Somatic mutations of the ret protooncogene in sporadic medullary thyroid carcinoma are not restricted to exon 16 and are associated with tumor recurrence","volume":"81","author":"C Romei","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1261\/rna.2274106","article-title":"Statistical and Bayesian approaches to RNA secondary structure prediction","volume":"12","author":"Y Ding","year":"2006","journal-title":"RNA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"i278","DOI":"10.1093\/bioinformatics\/btq218","article-title":"Thermodynamics of RNA structures by Wang-Landau sampling","volume":"26","author":"F Lou","year":"2010","journal-title":"Bioinformatics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0147840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:35:46Z","timestamp":1540258546000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0147840"}},"subtitle":[],"editor":[{"given":"H. Sunny","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0147840","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]}}}