{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:46Z","timestamp":1787847826492,"version":"build-2784847793"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 103-2314-B-002-187-MY3"],"award-info":[{"award-number":["MOST 103-2314-B-002-187-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0147916","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T19:11:54Z","timestamp":1480619514000},"page":"e0147916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors Associated with Cancer- and Non-Cancer-Related Deaths among Taiwanese Patients with Diabetes after 17 Years of Follow-Up"],"prefix":"10.1371","volume":"11","author":[{"given":"Chin-Hsiao","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"ref1","unstructured":"IDF Diabetes Atlas 2015 (7th edition). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.diabetesatlas.org\/resources\/2015-atlas.html\" xlink:type=\"simple\">http:\/\/www.diabetesatlas.org\/resources\/2015-atlas.html<\/ext-link> (last accessed November 2, 2016)."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00125-006-0314-4","article-title":"Increasing incidence of diagnosed type 2 diabetes in Taiwan: analysis of data from a national cohort","volume":"49","author":"CH Tseng","year":"2006","journal-title":"Diabetologia"},{"key":"ref3","first-page":"948","article-title":"2010 China Noncommunicable Disease Surveillance Group. Prevalence and control of diabetes in Chinese adults","volume":"310","author":"Y Xu","year":"2013","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1876524600902010018","article-title":"The epidemiologic transition of diabetes mellitus in Taiwan: Implications for reversal of female preponderance from a national cohort","volume":"2","author":"CH Tseng","year":"2009","journal-title":"Open Diabetes Journal"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"S Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.diabres.2010.09.032","article-title":"Gender differences in trends in diabetes prevalence from 1993 to 2008 in Taiwan","volume":"90","author":"HY Chang","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.atherosclerosis.2009.12.015","article-title":"Optimal anthropometric factor cutoffs for hyperglycemia, hypertension and dyslipidemia for the Taiwanese population","volume":"210","author":"CH Tseng","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1253\/circj.CJ-08-0009","article-title":"Hypertension is the most important component of metabolic syndrome in the association with ischemic heart disease in Taiwanese type 2 diabetic patients","volume":"72","author":"CH Tseng","year":"2008","journal-title":"Circ J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1253\/circj.71.1749","article-title":"Body mass index and blood pressure in adult type 2 diabetic patients in Taiwan","volume":"71","author":"CH Tseng","year":"2007","journal-title":"Circ J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1001\/archinte.166.11.1184","article-title":"Exogenous insulin use and hypertension in adult patients with type 2 diabetes mellitus","volume":"166","author":"CH Tseng","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2337\/diacare.27.7.1605","article-title":"Mortality and causes of death in a national sample of diabetic patients in Taiwan","volume":"27","author":"CH Tseng","year":"2004","journal-title":"Diabetes Care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00125-008-1204-8","article-title":"Secular trend for mortality from breast cancer and the association between diabetes and breast cancer in Taiwan between 1995 and 2006","volume":"52","author":"CH Tseng","year":"2009","journal-title":"Diabetologia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"E Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2337\/dc11-1449","article-title":"Pioglitazone and bladder cancer: a population-based study of Taiwanese","volume":"35","author":"CH Tseng","year":"2012","journal-title":"Diabetes Care"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/dc10-1640","article-title":"Diabetes and risk of prostate cancer: A study using the National Health Insurance","volume":"34","author":"CH Tseng","year":"2011","journal-title":"Diabetes Care"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10590501.2014.877645","article-title":"A review on thiazolidinediones and bladder cancer in human studies","volume":"32","author":"CH Tseng","year":"2014","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10590501.2015.1003496","article-title":"An updated review on cancer risk associated with incretin mimetics and enhancers","volume":"33","author":"CH Tseng","year":"2015","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5812\/ijem.7551","article-title":"Role of insulin in the type 2 diabetes therapy: past, present and future","volume":"11","author":"C Maria Rotella","year":"2013","journal-title":"Int J Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/annonc\/mdr334","article-title":"Diabetes and non-Hodgkin\u2019s lymphoma: Analyses of prevalence and annual incidence in 2005 using the National Health Insurance database in Taiwan","volume":"23","author":"CH Tseng","year":"2012","journal-title":"Ann Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"413782","DOI":"10.1155\/2012\/413782","article-title":"The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese","volume":"2012","author":"MC Hsieh","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.atherosclerosis.2012.09.004","article-title":"Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus","volume":"226","author":"CH Tseng","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00125-010-1949-8","article-title":"Effect of population screening for type 2 diabetes on mortality: long-term follow-up of the Ely cohort","volume":"54","author":"RK Simmons","year":"2011","journal-title":"Diabetologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00125-011-2441-9","article-title":"How much does screening bring forward the diagnosis of type 2 diabetes and reduce complications? Twelve year follow-up of the Ely cohort","volume":"55","author":"M Rahman","year":"2012","journal-title":"Diabetologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.1464-5491.2012.03570.x","article-title":"Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort","volume":"29","author":"M Rahman","year":"2012","journal-title":"Diabet Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/bmj.39303.723449.55","article-title":"Psychological impact of screening for type 2 diabetes: controlled trial and comparative study embedded in the ADDITION (Cambridge) randomised controlled trial","volume":"335","author":"HC Eborall","year":"2007","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1503\/cmaj.050680","article-title":"Prevalence of lower-extremity amputation among patients with diabetes mellitus: Is height a factor?","volume":"174","author":"CH Tseng","year":"2006","journal-title":"CMAJ"},{"key":"ref27","unstructured":"Canchola AJ, Stewart SL, Bernstein L, West DW, Ross RK, Deapen D, et al. Cox regression using different time-scales. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.lexjansen.com\/wuss\/2003\/DataAnalysis\/i-cox_time_scales.pdf\" xlink:type=\"simple\">http:\/\/www.lexjansen.com\/wuss\/2003\/DataAnalysis\/i-cox_time_scales.pdf<\/ext-link> (last accessed November 2, 2016)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1253\/circj.71.1749","article-title":"Body mass index and blood pressure in adult type 2 diabetic patients in Taiwan","volume":"71","author":"CH Tseng","year":"2007","journal-title":"Circ J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jacc.2008.12.068","article-title":"Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss","volume":"53","author":"CJ Lavie","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/clpt.2011.87","article-title":"Obesity and the &quot;obesity paradox&quot; in cardiovascular diseases","volume":"90","author":"CJ Lavie","year":"2011","journal-title":"Clin Pharmacol Ther"},{"issue":"Suppl 2","key":"ref31","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.2337\/dcS13-2023","article-title":"Obesity paradox does exist","volume":"36","author":"V Hainer","year":"2013","journal-title":"Diabetes Care"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2337\/dc10-0665","article-title":"Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study","volume":"34","author":"G Calori","year":"2011","journal-title":"Diabetes Care"},{"key":"ref33","article-title":"Part 1: Diagnosis and Classification of Diabetes Mellitus","year":"1999"},{"key":"ref34","article-title":"<italic>Diabetes Mellitus<\/italic>: <italic>Report of a Study Group<\/italic>","year":"1985"},{"key":"ref35","first-page":"678756","article-title":"Use of insulin and mortality from breast cancer among Taiwanese women with diabetes","author":"CH Tseng","year":"2015","journal-title":"J Diabetes Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1186\/s12885-015-1876-7","article-title":"Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes","volume":"15","author":"CH Tseng","year":"2015","journal-title":"BMC Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e77941","DOI":"10.1371\/journal.pone.0077941","article-title":"Smoking, menthol cigarettes and all-cause, cancer and cardiovascular mortality: evidence from the National Health and Nutrition Examination Survey (NHANES) and a meta-analysis","volume":"8","author":"MR Jones","year":"2013","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2337\/diacare.21.7.1138","article-title":"Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971\u20131993","volume":"21","author":"K Gu","year":"1998","journal-title":"Diabetes Care"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2337\/diacare.23.8.1119","article-title":"Verona Diabetes Study. Diabetes duration and cause-specific mortality in the Verona Diabetes Study","volume":"23","author":"E Brun","year":"2000","journal-title":"Diabetes Care"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"790654","DOI":"10.1155\/2013\/790654","article-title":"Body fat and body-mass index among a multiethnic sample of college-age men and women","volume":"2013","author":"CL Carpenter","year":"2013","journal-title":"J Obes"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0147916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:29:44Z","timestamp":1588987784000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0147916"}},"subtitle":[],"editor":[{"given":"David W.","family":"Dowdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0147916","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}