{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:44:52Z","timestamp":1791251092609,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148460","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T18:44:04Z","timestamp":1454611444000},"page":"e0148460","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Enzymatic Paradox of Yeast Arginyl-tRNA Synthetase: Exclusive Arginine Transfer Controlled by a Flexible Mechanism of tRNA Recognition"],"prefix":"10.1371","volume":"11","author":[{"given":"Ariel","family":"McShane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Hok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Tomberlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Eriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Geslain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1101\/gad.1187404","article-title":"Aminoacyl-tRNAs: setting the limits of the genetic code","volume":"18","author":"M Ibba","year":"2004","journal-title":"Genes Dev"},{"issue":"4874","key":"ref2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1126\/science.2459773","article-title":"Changing the acceptor identity of a transfer RNA by altering nucleotides in a "variable pocket"","volume":"241","author":"WH McClain","year":"1988","journal-title":"Science"},{"issue":"4937","key":"ref3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1126\/science.2688091","article-title":"The anticodon contains a major element of the identity of arginine transfer RNAs","volume":"246","author":"LH Schulman","year":"1989","journal-title":"Science"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/wrna.103","article-title":"Structure of transfer RNAs: similarity and variability","volume":"3","author":"R Gieg\u00e9","year":"2012","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"27","key":"ref5","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1021\/bi970206l","article-title":"The modified wobble base inosine in yeast tRNAIle is a positive determinant for aminoacylation by isoleucyl-tRNA synthetase","volume":"36","author":"B Senger","year":"1997","journal-title":"Biochemistry"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jmb.2011.12.054","article-title":"Modifications modulate anticodon loop dynamics and codon recognition of E. coli tRNA(Arg1,2)","volume":"416","author":"WA Cantara","year":"2012","journal-title":"J Mol Biol"},{"issue":"22","key":"ref7","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1093\/nar\/26.22.5017","article-title":"Universal rules and idiosyncratic features in tRNA identity","volume":"26","author":"R Gieg\u00e9","year":"1998","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"ref8","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1073\/pnas.251549298","article-title":"Recognizing the D-loop of transfer RNAs","volume":"98","author":"TL Hendrickson","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1002\/j.1460-2075.1993.tb06003.x","article-title":"Identity determinants of human tRNA(Ser): sequence elements necessary for serylation and maturation of a tRNA with a long extra arm","volume":"12","author":"T Achsel","year":"1993","journal-title":"EMBO J"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1006\/jmbi.1994.1186","article-title":"Escherichia coli seryl-tRNA synthetase recognizes tRNA(Ser) by its characteristic tertiary structure","volume":"236","author":"H Asahara","year":"1994","journal-title":"J Mol Biol"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1006\/jmbi.1999.3219","article-title":"Unique recognition style of tRNA(Leu) by Haloferax volcanii leucyl-tRNA synthetase","volume":"293","author":"A Soma","year":"1999","journal-title":"J Mol Biol"},{"key":"ref12","first-page":"143","article-title":"In vitro study of E. coli tRNA identity elements","volume":"27","author":"T Tamura","year":"1992","journal-title":"Nucleic Acids Symp Ser"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1093\/nar\/20.9.2335","article-title":"In vitro study of E.coli tRNA(Arg) and tRNA(Lys) identity elements","volume":"20","author":"K Tamura","year":"1992","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"ref14","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1002\/j.1460-2075.1996.tb00887.x","article-title":"Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts","volume":"15","author":"M Sissler","year":"1996","journal-title":"EMBO J"},{"issue":"16","key":"ref15","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1093\/nar\/gkg685","article-title":"A yeast knockout strain to discriminate between active and inactive tRNA molecules","volume":"31","author":"R Geslain","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-5793(98)01096-5","article-title":"Ribozyme processed tRNA transcripts with unfriendly internal promoter for T7 RNA polymerase: production and activity","volume":"436","author":"P Fechter","year":"1998","journal-title":"FEBS Lett"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ymeth.2007.09.007","article-title":"Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases","volume":"44","author":"CS Francklyn","year":"2008","journal-title":"Methods"},{"issue":"21","key":"ref18","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1093\/emboj\/19.21.5599","article-title":"tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding","volume":"19","author":"B Delagoutte","year":"2000","journal-title":"EMBO J"},{"issue":"5842","key":"ref19","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/294626a0","article-title":"Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements","volume":"294","author":"G Galli","year":"1981","journal-title":"Nature"},{"issue":"7549","key":"ref20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature14427","article-title":"Structure of the human 80S ribosome","volume":"520","author":"H Khatter","year":"2015","journal-title":"Nature"},{"issue":"Database issue","key":"ref21","doi-asserted-by":"crossref","first-page":"D159","DOI":"10.1093\/nar\/gkn772","article-title":"tRNAdb 2009: compilation of tRNA sequences and tRNA genes","volume":"37","author":"F J\u00fchling","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"36","key":"ref22","doi-asserted-by":"crossref","first-page":"24712","DOI":"10.1016\/S0021-9258(18)54288-5","article-title":"Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase","volume":"266","author":"U Varshney","year":"1991","journal-title":"J Biol Chem"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"e0130042","DOI":"10.1371\/journal.pone.0130042","article-title":"MIST, a Novel Approach to Reveal Hidden Substrate Specificity in Aminoacyl-tRNA Synthetases","volume":"10","author":"G Eriani","year":"2015","journal-title":"PLoS One"},{"issue":"23","key":"ref24","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1046\/j.0014-2956.2001.02570.x","article-title":"Shifted positioning of the anticodon nucleotide residues of amber suppressor tRNA species by Escherichia coli arginyl-tRNA synthetase","volume":"268","author":"D Kiga","year":"2001","journal-title":"Eur J Biochem"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1017\/S1355838200992331","article-title":"In vivo selection of lethal mutations reveals two functional domains in arginyl-tRNA synthetase","volume":"6","author":"R Geslain","year":"2000","journal-title":"RNA"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2003.11.107","article-title":"Escherichia coli tRNA(4)(Arg)(UCU) induces a constrained conformation of the crucial Omega-loop of arginyl-tRNA synthetase","volume":"313","author":"YN Yao","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"50","key":"ref27","doi-asserted-by":"crossref","first-page":"16540","DOI":"10.1021\/bi051575h","article-title":"Determinants in tRNA for activation of arginyl-tRNA synthetase: evidence that tRNA flexibility is required for the induced-fit mechanism","volume":"44","author":"L Guigou","year":"2005","journal-title":"Biochemistry"},{"issue":"15","key":"ref28","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1093\/nar\/23.15.2831","article-title":"Identity elements of tRNA(Thr) towards Saccharomyces cerevisiae threonyl-tRNA synthetase","volume":"23","author":"N Nameki","year":"1995","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"ref29","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1093\/nar\/21.22.5079","article-title":"Anticodon bases C34 and C35 are major, positive, identity elements in Saccharomyces cerevisiae tRNA(Trp)","volume":"21","author":"KD Yesland","year":"1993","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"ref30","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1093\/nar\/gkh843","article-title":"A yeast arginine specific tRNA is a remnant aspartate acceptor","volume":"32","author":"A Fender","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"5540","key":"ref31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/science.1064242","article-title":"Uniform binding of aminoacyl-tRNAs to elongation factor Tu by thermodynamic compensation","volume":"294","author":"FJ LaRiviere","year":"2001","journal-title":"Science"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jmb.2009.12.018","article-title":"Functional analysis of human tRNA isodecoders","volume":"396","author":"R Geslain","year":"2010","journal-title":"J Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.biochem.052308.105824","article-title":"Adding new chemistries to the genetic code","volume":"79","author":"CC Liu","year":"2010","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1093\/nar\/gkp1083","article-title":"Chimeric tRNAs as tools to induce proteome damage and identify components of stress responses","volume":"38","author":"R Geslain","year":"2010","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:23:14Z","timestamp":1654248194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148460"}},"subtitle":[],"editor":[{"given":"Lennart","family":"Randau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,4]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148460","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,4]]}}}