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Chang","year":"2014","journal-title":"J Cell Physiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/cncr.24702","article-title":"Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk","volume":"116","author":"WD Dupont","year":"2010","journal-title":"Cancer"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/cgt.2011.4","article-title":"Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase","volume":"18","author":"WB Parker","year":"2011","journal-title":"Cancer Gene Ther"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9440(10)63641-3","article-title":"The clinical significance of cathepsin S expression in human astrocytomas","volume":"163","author":"T Flannery","year":"2003","journal-title":"Am J Pathol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/bjc.2011.408","article-title":"The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study","volume":"105","author":"JA Gormley","year":"2011","journal-title":"Br J Cancer"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.onc.1203462","article-title":"The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma","volume":"19","author":"S Ren","year":"2000","journal-title":"Oncogene"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1038\/onc.2013.338","article-title":"Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a\/Nop56 in oncogenesis","volume":"33","author":"VH Cowling","year":"2014","journal-title":"Oncogene"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"e1828","DOI":"10.1371\/journal.pone.0001828","article-title":"A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging","volume":"3","author":"S Miretti","year":"2008","journal-title":"PLoS ONE"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1089\/scd.2012.0623","article-title":"Ddx46 is required for multi-lineage differentiation of hematopoietic stem cells in zebrafish","volume":"22","author":"R Hirabayashi","year":"2013","journal-title":"Stem Cells Dev"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1158\/1078-0432.CCR-05-0177","article-title":"Bladder cancer stage and outcome by array-based comparative genomic hybridization","volume":"11","author":"E Blaveri","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1242\/jcs.105981","article-title":"SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis","volume":"125","author":"MP Ma","year":"2012","journal-title":"J Cell Sci"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1038\/mtna.2014.9","article-title":"Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo","volume":"3","author":"T Arif","year":"2014","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1158\/0008-5472.CAN-11-3940","article-title":"Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance","volume":"72","author":"MC Brahimi-Horn","year":"2012","journal-title":"Cancer Res"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10863-008-9138-x","article-title":"Mitochondrial membrane cholesterol, the voltage dependent anion channel (VDAC), and the Warburg effect","volume":"40","author":"AM Campbell","year":"2008","journal-title":"J Bioenerg Biomembr"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"19870","DOI":"10.1074\/jbc.M112.448290","article-title":"An Interaction between Bcl-xL and the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+ Uptake","volume":"288","author":"H Huang","year":"2013","journal-title":"J Biol Chem"},{"key":"ref95","article-title":"VDAC1-based peptides: Novel pro-apoptotic agents and potential therapeutics for B cell chronic lymphocytic leukemia","author":"T Prezma","year":"2013","journal-title":"Cell Death and Disease in press"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.coi.2011.08.001","article-title":"Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter","volume":"23","author":"SM Belgnaoui","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1128\/MCB.00030-13","article-title":"MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1","volume":"33","author":"K Guan","year":"2013","journal-title":"Mol Cell Biol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"e5466","DOI":"10.1371\/journal.pone.0005466","article-title":"MAVS-mediated apoptosis and its inhibition by viral proteins","volume":"4","author":"Y Lei","year":"2009","journal-title":"PLoS ONE"},{"key":"ref99","first-page":"580","article-title":"Relationship between expression of Smac and Survivin and apoptosis of primary hepatocellular carcinoma","volume":"5","author":"ST Bao","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1471-2407-6-256","article-title":"High Smac\/DIABLO expression is associated with early local recurrence of cervical cancer","volume":"6","author":"A Arellano-Llamas","year":"2006","journal-title":"BMC Cancer"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pdm.0000213471.92925.51","article-title":"Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac\/DIABLO in gastric adenocarcinomas","volume":"16","author":"T Shibata","year":"2007","journal-title":"Diagn Mol Pathol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00432-007-0317-7","article-title":"Expression levels of the mitochondrial IAP antagonists Smac\/DIABLO and Omi\/HtrA2 in clear-cell renal cell carcinomas and their prognostic value","volume":"134","author":"C Kempkensteffen","year":"2008","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/35069004","article-title":"Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death","volume":"410","author":"N Joza","year":"2001","journal-title":"Nature"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tibs.2009.12.008","article-title":"Life with or without AIF","volume":"35","author":"E Hangen","year":"2010","journal-title":"Trends Biochem Sci"}],"container-title":["PLOS 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