{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:40:52Z","timestamp":1785584452569,"version":"3.56.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148634","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T18:54:13Z","timestamp":1454698453000},"page":"e0148634","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization"],"prefix":"10.1371","volume":"11","author":[{"given":"Mohammad Sarfaraz","family":"Nawaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"La Montanara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Ciceri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Alberio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Landsberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rusconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Kilstrup-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"ref1","first-page":"728267","article-title":"What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy","author":"C Kilstrup-Nielsen","year":"2012","journal-title":"Neural Plast"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ejhg.2012.156","article-title":"The CDKL5 disorder is an independent clinical entity associated with early-onset encephalopathy","volume":"21","author":"S Fehr","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/geno.1998.5391","article-title":"Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region","volume":"51","author":"E Montini","year":"1998","journal-title":"Genomics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"32048","DOI":"10.1074\/jbc.M606325200","article-title":"Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation","volume":"281","author":"I Bertani","year":"2006","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1074\/jbc.M804613200","article-title":"CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail","volume":"283","author":"L Rusconi","year":"2008","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00439-011-1058-x","article-title":"A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain","volume":"131","author":"SL Williamson","year":"2012","journal-title":"Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/hmg\/ddi198","article-title":"CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome","volume":"14","author":"F Mari","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"36550","DOI":"10.1074\/jbc.M111.235630","article-title":"Extrasynaptic N-methyl-D-aspartate (NMDA) receptor stimulation induces cytoplasmic translocation of the CDKL5 kinase and its proteasomal degradation","volume":"286","author":"L Rusconi","year":"2011","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"12777","DOI":"10.1523\/JNEUROSCI.1102-10.2010","article-title":"CDKL5, a protein associated with Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling","volume":"30","author":"Q Chen","year":"2010","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ncb2566","article-title":"CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons","volume":"14","author":"S Ricciardi","year":"2012","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9118","DOI":"10.1073\/pnas.1300003110","article-title":"Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development","volume":"110","author":"YC Zhu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21516","DOI":"10.1073\/pnas.1216988110","article-title":"Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice","volume":"109","author":"ITJ Wang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e91613","DOI":"10.1371\/journal.pone.0091613","article-title":"Mapping pathological phenotypes in a mouse model of CDKL5 disorder","volume":"9","author":"E Amendola","year":"2014","journal-title":"Plos One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1083\/jcb.108.4.1507","article-title":"Experimental observations on the development of polarity by hippocampal neurons in culture","volume":"108","author":"K Goslin","year":"1989","journal-title":"J Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.ne.17.030194.001411","article-title":"Neuronal polarity","volume":"17","author":"AM Craig","year":"1994","journal-title":"Annu Rev Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.31.060407.125536","article-title":"Establishment of axon-dendrite polarity in developing neurons","volume":"32","author":"AP Barnes","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.200604160","article-title":"Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization","volume":"175","author":"M Toriyama","year":"2006","journal-title":"J Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-neuro-061010-113618","article-title":"Early events in axon\/dendrite polarization","volume":"35","author":"PL Cheng","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1101\/gr.2659105","article-title":"Protein interaction mapping: a Drosophila case study","volume":"15","author":"E Formstecher","year":"2005","journal-title":"Genome Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gep.2009.11.005","article-title":"Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brainregions implicated in autism neuropathology","volume":"10","author":"F Bedogni","year":"2010","journal-title":"Gene Expr Patterns"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbrc.2008.10.113","article-title":"Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1","volume":"377","author":"I Kameshita","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1523\/JNEUROSCI.5425-12.2013","article-title":"Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons","volume":"33","author":"T Sapir","year":"2013","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.200712138","article-title":"Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth","volume":"181","author":"T Shimada","year":"2008","journal-title":"J Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cub.2013.02.017","article-title":"Conversion of a Signal into Forces for Axon Outgrowth through Pak1-Mediated Shootin1 Phosphorylation","volume":"23","author":"M Toriyama","year":"2013","journal-title":"Curr Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nbd.2014.06.006","article-title":"Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT\/GSK-3\u03b2 signaling","volume":"70","author":"C Fuchs","year":"2014","journal-title":"Neurobiol Dis"},{"key":"ref26","first-page":"18","article-title":"Development and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro","volume":"8","author":"G Baj","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"ref27","article-title":"Neurodevelopmental and neurobehavioral characteristics in males and females with CDKL5 duplications","volume":"217","author":"P Szafranski","year":"2014","journal-title":"Eur J Hum Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"11","author":"EM Hur","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"a001818","DOI":"10.1101\/cshperspect.a001818","article-title":"Rho and Ras GTPases in axon growth, guidance, and branching","volume":"2","author":"A Hall","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1523\/JNEUROSCI.5425-12.2013","article-title":"Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons","volume":"33","author":"T Sapir","year":"2013","journal-title":"J Neurosci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T09:19:01Z","timestamp":1567588741000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148634"}},"subtitle":[],"editor":[{"given":"Robert","family":"Blum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,5]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148634","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,5]]}}}