{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:39:18Z","timestamp":1775479158614,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148766","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T18:32:43Z","timestamp":1456425163000},"page":"e0148766","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating Endothelial Progenitor Cells and Clinical Outcome in Patients with Aortic Stenosis"],"prefix":"10.1371","volume":"11","author":[{"given":"Sara","family":"Shimoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery","family":"Meledin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Derazne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gera","family":"Gandelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"B Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/hh1301.093953","article-title":"Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease","volume":"89","author":"M Vasa","year":"2001","journal-title":"Circ Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"JM Hill","year":"2003","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa043814","article-title":"Circulating endothelial progenitor cells and cardiovascular outcomes","volume":"353","author":"N Werner","year":"2005","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"BF Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","article-title":"Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies","volume":"90","author":"CM Otto","year":"1994","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.ATV.16.4.523","article-title":"Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis","volume":"16","author":"KD O'Brien","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/01.ATV.0000130659.89433.c1","article-title":"Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity","volume":"24","author":"PF Davies","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00109-004-0580-x","article-title":"Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?","volume":"82","author":"S Dimmeler","year":"2004","journal-title":"J Mol Med (Berl)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"JE Deanfield","year":"2007","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.684381","article-title":"Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone","volume":"116","author":"SA Sorrentino","year":"2007","journal-title":"Circulation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jacc.2003.12.041","article-title":"Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis","volume":"43","author":"A Mazzone","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies","volume":"111","author":"RV Freeman","year":"2005","journal-title":"Circulation"},{"key":"ref14","first-page":"24","article-title":"Ultrastructural alterations in acquired aortic and mitral valve disease as revealed by scanning and transmission electron microscopical investigations","volume":"8","author":"M Mirzaie","year":"2002","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/eurheartj\/ehi458","article-title":"Cells of primarily extra-valvular origin in degenerative aortic valves and bioprostheses","volume":"26","author":"D Skowasch","year":"2005","journal-title":"Eur Heart J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/eurheartj\/ehn501","article-title":"Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair","volume":"30","author":"Y Matsumoto","year":"2009","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2012.07.042","article-title":"Role of circulating osteogenic progenitor cells in calcific aortic stenosis","volume":"60","author":"M Gossl","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1749-8090-7-2","article-title":"Decreased pre-surgical CD34+\/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients","volume":"7","author":"S Redondo","year":"2012","journal-title":"J Cardiothorac Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"RA Nishimura","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"RM Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1067\/mje.2002.120202","article-title":"Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography","volume":"15","author":"MA Quinones","year":"2002","journal-title":"J Am Soc Echocardiogr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ejechocard\/jen303","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"10","author":"H Baumgartner","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/ten.2006.12.331","article-title":"Comparative analysis of methods for assessment of circulating endothelial progenitor cells","volume":"12","author":"J George","year":"2006","journal-title":"Tissue Eng"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2004-05-1831","article-title":"Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction","volume":"105","author":"M Massa","year":"2005","journal-title":"Blood"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/ATVBAHA.107.160317","article-title":"Circulating endothelial progenitor cells exhibit diurnal variation","volume":"28","author":"HE Thomas","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/01.CIR.0000136813.89036.21","article-title":"CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure","volume":"110","author":"M Valgimigli","year":"2004","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/hrt.2006.102657","article-title":"Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure","volume":"93","author":"Y Michowitz","year":"2007","journal-title":"Heart"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0735-1097(00)00721-X","article-title":"Elevated circulating levels of serum tumor necrosis factor-alpha in patients with hemodynamically significant pressure and volume overload","volume":"36","author":"SR Kapadia","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/jpet.110.177915","article-title":"Tumor necrosis factor-alpha accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway","volume":"337","author":"Z Yu","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/eurheartj\/ehs190","article-title":"Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal","volume":"33","author":"S Bhattacharyya","year":"2012","journal-title":"Eur Heart J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/scrt382","article-title":"Difference in mobilization of progenitor cells after myocardial infarction in smoking versus non-smoking patients: insights from the BONAMI trial","volume":"4","author":"G Lamirault","year":"2013","journal-title":"Stem Cell Res Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:08:07Z","timestamp":1692234487000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148766"}},"subtitle":[],"editor":[{"given":"Maria Cristina","family":"Vinci","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148766","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]}}}