{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:03:53Z","timestamp":1776459833738,"version":"3.51.2"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148794","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T18:37:27Z","timestamp":1455215847000},"page":"e0148794","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Increased Epicardial Adipose Tissue Is Associated with the Airway Dominant Phenotype of Chronic Obstructive Pulmonary Disease"],"prefix":"10.1371","volume":"11","author":[{"given":"Yuichi","family":"Higami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Ryujin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruriko","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Van","family":"Tho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi Tuyet","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Par\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1164\/rccm.201004-0665OC","article-title":"Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. The TORCH experience","volume":"183","author":"B Celli","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1378\/chest.128.4.2099","article-title":"Patterns of comorbidities in newly diagnosed COPD and asthma in primary care","volume":"128","author":"JB Soriano","year":"2005","journal-title":"Chest"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1378\/chest.11-2421","article-title":"Relation between COPD severity and global cardiovascular risk in US adults","volume":"142","author":"HM Lee","year":"2012","journal-title":"Chest"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-142-4-200502150-00005","article-title":"The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial","volume":"142","author":"NR Anthonisen","year":"2005","journal-title":"Ann Intern Med"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease","volume":"356","author":"PM Calverley","year":"2007","journal-title":"The New England journal of medicine"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3945\/ajcn.2008.27358","article-title":"The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"90","author":"J Ding","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"13","key":"ref7","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jacc.2012.11.062","article-title":"Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study","volume":"61","author":"AA Mahabadi","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"e65593","DOI":"10.1371\/journal.pone.0065593","article-title":"Epicardial adipose tissue in patients with chronic obstructive pulmonary disease","volume":"8","author":"J Zagaceta","year":"2013","journal-title":"PLoS One"},{"issue":"6 Suppl","key":"ref9","doi-asserted-by":"crossref","first-page":"271S","DOI":"10.1378\/chest.122.6_suppl.271S","article-title":"Quantitative assessment of airway remodeling using high-resolution CT","volume":"122","author":"Y Nakano","year":"2002","journal-title":"Chest"},{"issue":"3 Pt 1","key":"ref10","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1164\/ajrccm.162.3.9907120","article-title":"Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function","volume":"162","author":"Y Nakano","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/thx.2008.097543","article-title":"Body mass index in male patients with COPD: correlation with low attenuation areas on CT","volume":"64","author":"E Ogawa","year":"2009","journal-title":"Thorax"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"MR Miller","year":"2005","journal-title":"Eur Respir J"},{"issue":"Suppl","key":"ref13","first-page":"1","article-title":"Guideline of respiratory function tests\u2014spirometry, flow-volume curve, diffusion capacity of the lung","year":"2004","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"e98335","DOI":"10.1371\/journal.pone.0098335","article-title":"Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers","volume":"9","author":"NV Tho","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.200407-874OC","article-title":"The prediction of small airway dimensions using computed tomography","volume":"171","author":"Y Nakano","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11604-010-0524-z","article-title":"Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?","volume":"29","author":"N Oyama","year":"2011","journal-title":"Jpn J Radiol"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"AS Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"ref19","article-title":"A Mixed Phenotype of Airway Wall Thickening and Emphysema Is Associated with Dyspnea and Hospitalization for COPD","author":"NV Tho","year":"2015","journal-title":"Annals of the American Thoracic Society"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2012.9624","article-title":"Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals","volume":"308","author":"J Yeboah","year":"2012","journal-title":"JAMA"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.107.743062","article-title":"Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study","volume":"117","author":"GA Rosito","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9150(00)00709-7","article-title":"Pericardial fat accumulation in men as a risk factor for coronary artery disease","volume":"157","author":"R Taguchi","year":"2001","journal-title":"Atherosclerosis"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/eurheartj\/ehn573","article-title":"Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study","volume":"30","author":"AA Mahabadi","year":"2009","journal-title":"Eur Heart J"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1843.2004.00611.x","article-title":"Clinical phenotypes of COPD: results of a Japanese epidemiological survey","volume":"9","author":"K Tatsumi","year":"2004","journal-title":"Respirology"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1309\/JC477FAEL1YKV54W","article-title":"Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease","volume":"126","author":"AR Kranenburg","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"ref26","first-page":"423","article-title":"Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease","volume":"6","author":"R Furutate","year":"2011","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"3","key":"ref27","first-page":"470","article-title":"Body composition phenotypes in systemic lupus erythematosus and rheumatoid arthritis: a comparative study of Caucasian female patients","volume":"29","author":"MJ Santos","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000254482","article-title":"Increased amount of visceral fat in patients with psoriasis contributes to metabolic syndrome","volume":"220","author":"A Balci","year":"2010","journal-title":"Dermatology"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1002\/art.27629","article-title":"Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics","volume":"62","author":"JT Giles","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3945\/ajcn.112.040774","article-title":"The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease","volume":"96","author":"B van den Borst","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/07853890.2011.564202","article-title":"Visceral adiposity as a target for the management of the metabolic syndrome","volume":"44","author":"K Kishida","year":"2012","journal-title":"Ann Med"},{"issue":"13","key":"ref32","first-page":"2461","article-title":"Epicardial adipose tissue thickness in patients with chronic obstructive pulmonary disease having right ventricular systolic dysfunction","volume":"19","author":"O Kaplan","year":"2015","journal-title":"European review for medical and pharmacological sciences"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/thoraxjnl-2012-203151","article-title":"Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality","volume":"69","author":"MC Williams","year":"2014","journal-title":"Thorax"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ejrad.2005.12.030","article-title":"Mapping epicardial fat with multi-detector computed tomography to facilitate percutaneous transepicardial arrhythmia ablation","volume":"57","author":"S Abbara","year":"2006","journal-title":"European journal of radiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:34:25Z","timestamp":1540233265000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148794"}},"subtitle":[],"editor":[{"given":"Stelios","family":"Loukides","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148794","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}