{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:12:12Z","timestamp":1784783532457,"version":"3.55.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148866","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T18:57:39Z","timestamp":1455303459000},"page":"e0148866","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Endothelin System in Renal Structure and Function during the Postnatal Development of the Rat Kidney"],"prefix":"10.1371","volume":"11","author":[{"given":"Mar\u00eda F.","family":"Albertoni Borghese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Balonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Moreira Szokalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica P.","family":"Majowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1111\/bph.12874","article-title":"Endothelin@25\u2014new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12","volume":"171","author":"JJ Maguire","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00060.2009","article-title":"Regulation of blood pressure and salt homeostasis by endothelin","volume":"91","author":"DE Kohan","year":"2011","journal-title":"Physiol Rev"},{"issue":"13\u201314","key":"ref3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.lfs.2012.03.026","article-title":"Endothelin and endothelin receptors in the renal and cardiovascular systems","volume":"91","author":"N Vignon-Zellweger","year":"2012","journal-title":"Life Sci"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00060.2009","article-title":"Regulation of blood pressure and salt homeostasis by endothelin","volume":"91","author":"DE Kohan","year":"2011","journal-title":"Physiol Rev"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0031-6997(25)06809-7","article-title":"Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology","volume":"46","author":"GM Rubanyi","year":"1994","journal-title":"Pharmacol Rev"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"F303","DOI":"10.1152\/ajprenal.00127.2002","article-title":"Endothelin-1 activates mesangial cell ERK1\/2 via EGF-receptor transactivation and caveolin-1 interaction","volume":"284","author":"H Hua","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/dbio.1999.9527","article-title":"Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice","volume":"217","author":"DE Clouthier","year":"2000","journal-title":"Dev Biol"},{"issue":"6473","key":"ref8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/368703a0","article-title":"Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1","volume":"368","author":"Y Kurihara","year":"1994","journal-title":"Nature"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1172\/JCI118033","article-title":"Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1","volume":"96","author":"Y Kurihara","year":"1995","journal-title":"J Clin Invest"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1242\/dev.125.5.825","article-title":"Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene","volume":"125","author":"H Yanagisawa","year":"1998","journal-title":"Development"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(94)90017-5","article-title":"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice","volume":"79","author":"K Hosoda","year":"1994","journal-title":"Cell"},{"issue":"Suppl 48","key":"ref12","doi-asserted-by":"crossref","first-page":"167S","DOI":"10.1042\/CS103S167S","article-title":"Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period","volume":"103","author":"T Uchide","year":"2002","journal-title":"Clin Sci (Lond)"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008300","article-title":"Mammalian kidney development: principles, progress, and projections","volume":"4","author":"MH Little","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0006-291X(03)00769-1","article-title":"Increased gene expression and production of murine endothelin receptors after birth","volume":"305","author":"J Adur","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00862072","article-title":"Decrease in endothelin-1 renal receptors during the 1st month of life in the rat","volume":"10","author":"L Abadie","year":"1996","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3346\/jkms.2009.24.1.138","article-title":"Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney","volume":"24","author":"KH Yoo","year":"2009","journal-title":"J Korean Med Sci"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"F506","DOI":"10.1152\/ajprenal.00066.2007","article-title":"Sex and age differences of renal function in rats with reduced ANG II activity during the nephrogenic period","volume":"293","author":"A Loria","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"R695","DOI":"10.1152\/ajpregu.00191.2007","article-title":"Changes in renal hemodynamics and excretory function induced by a reduction of ANG II effects during renal development","volume":"293","author":"A Loria","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/HYPERTENSIONAHA.107.087957","article-title":"Sex differences in the renal changes elicited by angiotensin II blockade during the nephrogenic period","volume":"49","author":"F Saez","year":"2007","journal-title":"Hypertension"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1607-551X(09)70325-0","article-title":"Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with","volume":"22","author":"HT Kuo","year":"2006","journal-title":"Angiotensin II. Kaohsiung J Med Sci"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1607-551X(09)70393-6","article-title":"Endothelin-1 antisense oligonucleotide suppresses the proliferation of glomerular mesangial cells stimulated with angiotensin-II","volume":"23","author":"JJ Lee","year":"2007","journal-title":"Kaohsiung J Med Sci"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"F506","DOI":"10.1152\/ajprenal.00066.2007","article-title":"Sex and age differences of renal function in rats with reduced ANG II activity during the nephrogenic period","volume":"293","author":"A Loria","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1681\/ASN.V1071550","article-title":"Postnatal time frame for renal vulnerability to enalapril in rats","volume":"10","author":"G Guron","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"5\u20136","key":"ref24","first-page":"431","article-title":"Cell proliferation and morphometric changes in the rat kidney during postnatal development","volume":"205","author":"MG Marquez","year":"2002","journal-title":"Anat Embryol (Berl)"},{"key":"ref25","first-page":"72","article-title":"The kidney: Physiology and Pathology","author":"SK Nigam","year":"1996"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/HYPERTENSIONAHA.113.01194","article-title":"Progression of glomerular filtration rate reduction determined in conscious Dahl salt-sensitive hypertensive rats","volume":"62","author":"AW Cowley Jr.","year":"2013","journal-title":"Hypertension"},{"key":"ref27","first-page":"26","article-title":"On the existence of non-urine forming nephrons in the diseased kidney of the dog","volume":"65","author":"RV Damadian","year":"1965","journal-title":"J Lab Clin Med"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.nut.2012.09.008","article-title":"Mild zinc deficiency in male and female rats: early postnatal alterations in renal nitric oxide system and morphology","volume":"29","author":"AL Tomat","year":"2013","journal-title":"Nutrition"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.nut.2012.09.008","article-title":"Mild zinc deficiency in male and female rats: early postnatal alterations in renal nitric oxide system and morphology","volume":"29","author":"AL Tomat","year":"2013","journal-title":"Nutrition"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"R543","DOI":"10.1152\/ajpregu.00050.2008","article-title":"Moderate zinc restriction during fetal and postnatal growth of rats: effects on adult arterial blood pressure and kidney","volume":"295","author":"AL Tomat","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/01902149509031745","article-title":"Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs","volume":"21","author":"W Malkusch","year":"1995","journal-title":"Exp Lung Res"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000101689.64849.97","article-title":"Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats","volume":"42","author":"T Suganami","year":"2003","journal-title":"Hypertension"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.coph.2014.12.007","article-title":"Endothelin receptors, renal effects and blood pressure","volume":"21","author":"EI Boesen","year":"2015","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4161\/org.6.3.12125","article-title":"The relationship between nephron number, kidney size and body weight in two inbred mouse strains","volume":"6","author":"IJ Murawski","year":"2010","journal-title":"Organogenesis"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MNH.0b013e3282f9b1a5","article-title":"Nephron number, glomerular volume, renal disease and hypertension","volume":"17","author":"WE Hoy","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00049.2008","article-title":"Developmental programming of a reduced nephron endowment: more than just a baby&apos;s birth weight","volume":"296","author":"KM Moritz","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000211324","article-title":"The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development","volume":"30","author":"M Puddu","year":"2009","journal-title":"Am J Nephrol"},{"key":"ref38","first-page":"128","article-title":"The regulation of apoptosis in kidney development: implications for nephron number and pattern?","volume":"2","author":"J Ho","year":"2014","journal-title":"Front Pediatr"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3346\/jkms.2009.24.1.138","article-title":"Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney","volume":"24","author":"KH Yoo","year":"2009","journal-title":"J Korean Med Sci"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/157016107779317161","article-title":"Endothelin-1-induced signaling pathways in vascular smooth muscle cells","volume":"5","author":"A Bouallegue","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2121-10-52","article-title":"Role of ERK\/MAPK in endothelin receptor signaling in human aortic smooth muscle cells","volume":"10","author":"QW Chen","year":"2009","journal-title":"BMC Cell Biol"},{"issue":"Suppl 48","key":"ref42","doi-asserted-by":"crossref","first-page":"132S","DOI":"10.1042\/CS103S132S","article-title":"Endothelin signalling and regulation of protein kinases in glomerular mesangial cells","volume":"103","author":"A Sorokin","year":"2002","journal-title":"Clin Sci (Lond)"},{"issue":"21","key":"ref43","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1093\/emboj\/16.21.6439","article-title":"Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase","volume":"16","author":"M Foschi","year":"1997","journal-title":"EMBO J"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/157016107779317161","article-title":"Endothelin-1-induced signaling pathways in vascular smooth muscle cells","volume":"5","author":"A Bouallegue","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"issue":"Pt 3","key":"ref45","first-page":"595","article-title":"The sizes of renal glomeruli in fetuses and infants","volume":"130","author":"LP Souster","year":"1980","journal-title":"J Anat"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1681\/ASN.2005010123","article-title":"Determinants of glomerular volume in different cortical zones of the human kidney","volume":"16","author":"T Samuel","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.ackd.2011.06.001","article-title":"Glomerular proteinuria: a complex interplay between unique players","volume":"18","author":"P Garg","year":"2011","journal-title":"Adv Chronic Kidney Dis"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ckj\/sfs001","article-title":"Endothelin and the podocyte","volume":"5","author":"M Barton","year":"2012","journal-title":"Clin Kidney J"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1681\/ASN.2013030252","article-title":"TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation","volume":"25","author":"SI Kim","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1476-5381.2012.01826.x","article-title":"Early progress in epigenetic regulation of endothelin pathway genes","volume":"168","author":"AK Welch","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7326\/0003-4819-118-6-199303150-00006","article-title":"Influence of sex hormones on plasma endothelin levels","volume":"118","author":"KH Polderman","year":"1993","journal-title":"Ann Intern Med"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/CS20070169","article-title":"Endothelin, sex and hypertension","volume":"114","author":"RC Tostes","year":"2008","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/1440-1681.12084","article-title":"Endothelin ET(B) receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet","volume":"40","author":"W Kittikulsuth","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"8","key":"ref54","doi-asserted-by":"crossref","first-page":"F1099","DOI":"10.1152\/ajprenal.00400.2013","article-title":"Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD","volume":"305","author":"C Jin","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/MNH.0000000000000185","article-title":"Endothelin-1 and the kidney: new perspectives and recent findings","volume":"25","author":"C De Miguel","year":"2016","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1476-5381.2012.01922.x","article-title":"ET-1 actions in the kidney: evidence for sex differences","volume":"168","author":"W Kittikulsuth","year":"2013","journal-title":"Br J Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T11:01:26Z","timestamp":1748775686000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148866"}},"subtitle":[],"editor":[{"given":"Diego","family":"Alvarez de la Rosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148866","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}