{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:39:07Z","timestamp":1792546747081,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0148903","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T17:44:39Z","timestamp":1458236679000},"page":"e0148903","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cardiovascular Variability Analysis and Baroreflex Estimation in Patients with Type 2 Diabetes in Absence of Any Manifest Neuropathy"],"prefix":"10.1371","volume":"11","author":[{"given":"S\u00edlvia Cristina Garcia","family":"de Moura-Tonello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"de Almeida Fagundes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina de Oliveira","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Rehder-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Cristina","family":"Milan-Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Polaquini","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana de Oliveira","family":"Gois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparecida Maria","family":"Catai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3949\/ccjm.68.11.928","article-title":"Recognizing and treating diabetic autonomic neuropathy","volume":"68","author":"AI Vinik","year":"2001","journal-title":"Cleve Clin J Med"},{"key":"ref2","first-page":"7","article-title":"Estudo comparativo da assist\u00eancia ao pacientes portador de diabetes mellitus na rede p\u00fablica de sa\u00fade, entre munic\u00edpios do estado do Paran\u00e1 \u2013Brasil, nos anos de 2004 e 2005","volume":"10","author":"JG Pereira","year":"2008","journal-title":"Revista Espa\u00e7o para a Sa\u00fade"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1007\/s001250050851","article-title":"Time and frequency domain estimates of spontaneous baroreflex sensitivity provide early detection of autonomic dysfunction in diabetes mellitus","volume":"40","author":"A Frattola","year":"1997","journal-title":"Diabetologia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF02292769","article-title":"Time- and frequency-domain estimation of early diabetic cardiovascular autonomic neuropathy","volume":"11","author":"D Ziegler","year":"2001","journal-title":"Clin Auton Res"},{"key":"ref5","first-page":"398","article-title":"Spontaneous baroreflex sensitivity in subjects with type 1 diabetes with and without cardiovascular autonomic neuropathy","volume":"59","author":"A Kaminska","year":"2008","journal-title":"Endokrynol Pol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2337\/diacare.22.3.388","article-title":"Noninvasive exploring of cardiac autonomic neuropathy","volume":"22","author":"M Ducher","year":"1999","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1365-2362.2003.01170.x","article-title":"Impaired cardiovagal and vasomotor responses to baroreceptor stimulation in type II diabetes mellitus","volume":"33","author":"EO Sanya","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.HYP.0000169053.14440.7d","article-title":"Diabetic neuropathy is a more important determinant of baroreflex sensitivity than carotid elasticity in type 2 diabetes","volume":"46","author":"J Ruiz","year":"2005","journal-title":"Hypertension"},{"key":"ref9","first-page":"1043","article-title":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Standard of measurement, physiological interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.33549\/physiolres.932510","article-title":"Diagnostic significance of a mild decrease of baroreflex sensitivity with respect of heart rate in type 1 diabetes mellitus","volume":"63","author":"J Svacinov\u00e1","year":"2013","journal-title":"Physiol Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.RES.59.2.178","article-title":"Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog","volume":"59","author":"M Pagani","year":"1986","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/01.HYP.12.6.600","article-title":"Changes in autonomic regulation induced by physical training in mild hypertension","volume":"12","author":"M Pagani","year":"1988","journal-title":"Hypertension"},{"key":"ref13","first-page":"S79","article-title":"A new approach to analysis of the arterial baroreflex","volume":"3","author":"G Bertinieri","year":"1985","journal-title":"J Hypertens"},{"key":"ref14","first-page":"R378","article-title":"Causal relationships between heart period and systolic arterial pressure during graded head-up tilt","volume":"300","author":"A Porta","year":"2011","journal-title":"Am J Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/01.CIR.101.8.886","article-title":"Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus","volume":"101","author":"R Furlan","year":"2000","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0100-879X2010007500137","article-title":"Spectral and symbolic analysis of the effect of gender and postural change on cardiac autonomic modulation in healthy elderly subjects","volume":"44","author":"NM Perseguini","year":"2011","journal-title":"Braz J Med Biol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10286-004-0182-2","article-title":"Comparison of the active standing test and head-up tilt test for diagnosis of syncope in childhood and adolescence","volume":"14","author":"R Matsushima","year":"2004","journal-title":"Clin Auton Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.2337\/diacare.28.4.956","article-title":"Diabetic Neuropathies. A statement by the American Diabetes Association","volume":"28","author":"AJM Boulton","year":"2005","journal-title":"Diabetes Care"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5603\/CJ.2013.0130","article-title":"Baroreceptor sensitivity and diabetes mellitus","volume":"20","author":"OO Rowaiye","year":"2013","journal-title":"Cardiol J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ecl.2013.06.001","article-title":"Diabetic Neuropathy","volume":"42","author":"AI Vinik","year":"2013","journal-title":"Endocrinol Metab Clin N Am"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02522855","article-title":"Performance assessment of standard algorithms for dynamic RT interval measurement: comparison between RTapex and RTend approach","volume":"36","author":"A Porta","year":"1998","journal-title":"Med Biol Eng Comput"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1088\/0967-3334\/32\/11\/S05","article-title":"Non-stationarities significantly distort short-term spectral, symbolic and entropy heart rate variability indexes","volume":"32","author":"V Magagnin","year":"2011","journal-title":"Physiol Meas"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.6166045","article-title":"Power spectrum analysis of heart rate fluctuations: a quantitative probe of beat-to-beat cardiovascular control","volume":"213","author":"S Akselrod","year":"1981","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1152\/japplphysiol.00537.2013","article-title":"Model-based causal closed-loop approach to the estimate of baroreflex sensitivity during propofol anesthesia in patients undergoing coronary artery bypass graft","volume":"115","author":"A Porta","year":"2013","journal-title":"J Appl Physiol"},{"key":"ref25","first-page":"H2558","article-title":"Assessing baroreflex gain from spontaneous variability in conscious dogs: role of causality and respiration","volume":"279","author":"A Porta","year":"2000","journal-title":"Am J Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF02441589","article-title":"Relationships between short-term blood pressure fluctuations and heart rate variability in resting subjects I: a spectral analysis approach","volume":"23","author":"RW De Boer","year":"1985","journal-title":"Med Biol Eng Comput"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00422-001-0292-z","article-title":"Quantifying the stre ngth of linear causal coupling in closed loop interacting cardiovascular variability series","volume":"86","author":"A Porta","year":"2002","journal-title":"Biol Cybern"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1365-2362.2003.01263.x","article-title":"Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins","volume":"33","author":"SE Borggreve","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2337\/dc09-9033","article-title":"International expert committee report on the role of the A1C assay in the diagnosis of diabetes","volume":"32","year":"2009","journal-title":"Diabetes Care"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.jacc.2014.06.1201","article-title":"Adverse effects of cigarette and noncigarette smoke exposure on the autonomic nervous system: mechanisms and implications for cardiovascular risk","volume":"64","author":"HR Middlekauff","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00000441-200107000-00005","article-title":"Spontaneous baroreflex sensitivity and heart rate variability are not superior to classic autonomic testing in older patients with type 2 diabetes","volume":"322","author":"J Tank","year":"2001","journal-title":"Am J Med Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.106.634949","article-title":"Diabetic cardiovascular autonomic neuropathy","volume":"115","author":"AI Vinik","year":"2007","journal-title":"Circulation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-5996-6-13","article-title":"Influence of type 2 diabetes on symbolic analysis and complexity of heart rate variability in men","volume":"6","author":"SC Moura-Tonello","year":"2014","journal-title":"Diabet Metab Syndrome"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e89463","DOI":"10.1371\/journal.pone.0089463","article-title":"Effect of age on complexity and causality of the cardiovascular control: comparison between model-based and model-free approaches","volume":"9","author":"A Porta","year":"2014","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2012.10.010","article-title":"Editorial on arterial baroreflex issue","volume":"172","author":"D Robertson","year":"2012","journal-title":"Auton Neurosci:Basic Clin"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(81)90061-1","article-title":"Heart rate changes in diabetes mellitus","volume":"1","author":"DJ Ewing","year":"1981","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1475-097X.2005.00623.x","article-title":"Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus","volume":"25","author":"M Javorka","year":"2005","journal-title":"Clin Physiol Funct Imaging"},{"key":"ref38","first-page":"H1777","article-title":"Exploring directionality in spontaneous heart period and systolic pressure variability interactions in humans: implications in the evaluation of baroreflex gain","volume":"288","author":"G Nollo","year":"2005","journal-title":"Am J Physiol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0174492","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0148903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T08:27:20Z","timestamp":1600331240000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0148903"}},"subtitle":[],"editor":[{"given":"Tohru","family":"Minamino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0148903","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0174492","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}