{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:32:55Z","timestamp":1782135175251,"version":"3.54.5"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149100","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T18:46:41Z","timestamp":1455302801000},"page":"e0149100","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin"],"prefix":"10.1371","volume":"11","author":[{"given":"Derek M.","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Papich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"issue":"4","key":"ref1","first-page":"342","article-title":"Rational dosing of antimicrobial agents for bovine respiratory disease: The use of plasma versus tissue concentrations in predicting efficacy","volume":"9","author":"S Gigu\u00e8re","year":"2011","journal-title":"Int J Appl Res Vet Med"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2460\/ajvr.2005.66.342","article-title":"Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with <italic>Mannheimia haemolytica<\/italic>","volume":"66","author":"TN TerHune","year":"2005","journal-title":"Am J Vet Res"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1365-2885.2011.01349.x","article-title":"Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle)","volume":"35","author":"M Menge","year":"2012","journal-title":"J Vet Pharmacol Therap"},{"issue":"4","key":"ref4","first-page":"269","article-title":"Pharmacokinetic evaluation of ceftiofur in serum, tissue chamber fluid and bronchial secretions from healthy beef-bred calves","volume":"56","author":"SL Halstead","year":"1992","journal-title":"Can J Vet Res"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1128\/AAC.43.8.1988","article-title":"Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration","volume":"43","author":"Q McKellar","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1164\/rccm.200301-111OC","article-title":"Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid","volume":"168","author":"K Yamazaki","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1128\/AAC.00133-06","article-title":"Interpretation of antibiotic concentration ratios measured in epithelial lining fluid","volume":"52","author":"S Kiem","year":"2008","journal-title":"Antimicrob Agents Chemotherap"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0924-8579(02)00024-9","article-title":"Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations","volume":"19","author":"P Liu","year":"2002","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jac\/dkm476","article-title":"Tissue concentrations: do we ever learn?","volume":"61","author":"JW Mouton","year":"2008","journal-title":"J Antimicrob Chemotherap"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.coph.2007.05.003","article-title":"Tissue penetration of antibacterial agents: how should this be incorporated into pharmacodynamic analyses?","volume":"7","author":"U Theuretzbacher","year":"2007","journal-title":"Curr Opin Pharmacol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2885.2007.00914.x","article-title":"Pharmacokinetics and tissue distribution of enrofloxacin and its active metabolite ciprofloxacin in calves","volume":"30","author":"JL Davis","year":"2007","journal-title":"J Vet Pharmacol Therap"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2885.2011.01338.x","article-title":"Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs","volume":"35","author":"KM Messenger","year":"2012","journal-title":"J Vet Pharmacol Therap"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.2460\/ajvr.69.8.997","article-title":"Pharmacokinetics of florfenicol in serum and synovial fluid after regional intravenous perfusion in the distal portion of the hind limb of adult cows","volume":"69","author":"JN Gilliam","year":"2008","journal-title":"Am J Vet Res"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-2885.2011.01323.x","article-title":"Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection","volume":"35","author":"K Holmes","year":"2011","journal-title":"J Vet Pharmacol Therap"},{"issue":"1","key":"ref15","first-page":"26","article-title":"Liquid chromatographic determination of desfuroylceftiofur metabolite of ceftiofur as residue in cattle plasma","volume":"73","author":"PS Jaglan","year":"1990","journal-title":"J Assoc Off Anal Chem"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1021\/jf0351624","article-title":"An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung","volume":"52","author":"D G\u00e1ler","year":"2004","journal-title":"J Agric Food Chem"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jps.2600710432","article-title":"General derivation of the equation for time to reach a certain fraction of steady state","volume":"71","author":"D Perrier","year":"1982","journal-title":"J Pharm Sci"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0924-8579(02)00022-5","article-title":"Animal model pharmacokinetics and pharmacodynamics: a critical review","volume":"19","author":"D Andes","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"ref19","unstructured":"Food and Drug Administration. Guidance for industry: guideline for the format and content of the microbiology section of an application. 1997."},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/AAC.36.6.1176","article-title":"Pulmonary disposition of antimicrobial agents: in vivo observations and clinical relevance","volume":"36","author":"DR Baldwin","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"issue":"suppl 3","key":"ref21","first-page":"iii61","article-title":"What are the properties that make an antibiotic acceptable for therapy of community-acquired pneumonia?","volume":"66","author":"GL Drusano","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/jvp.12015","article-title":"Pulmonary pharmacokinetics of tulathromycin in swine. Part 2: Intra\u2010airways compartments","volume":"36","author":"N Villarino","year":"2013","journal-title":"J Vet Pharmacol Therap"},{"issue":"3","key":"ref23","first-page":"129","article-title":"Rapid and prolonged distribution of tulathromycin into lung homogenate and pulmonary epithelial lining fluid of Holstein calves following a single subcutaneous administration of 2.5 mg\/kg body weight","volume":"8","author":"SR Cox","year":"2010","journal-title":"Intern J Appl Res Vet Med"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jvp.12080","article-title":"Understanding the pharmacokinetics of tulathromycin: a pulmonary perspective","volume":"37","author":"N Villarino","year":"2014","journal-title":"J Vet Pharmacol Therap"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1128\/AAC.36.6.1171","article-title":"Pulmonary disposition of antimicrobial agents: methodological considerations","volume":"36","author":"DR Baldwin","year":"1992","journal-title":"Antimicrob Agents Chemotherap"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/arrd.1987.135.6.1276","article-title":"Limitations of using urea to quantify epithelial lining fluid recovered by bronchoalveolar lavage","volume":"135","author":"TW Marcy","year":"1987","journal-title":"Am Rev Respir Dis"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijantimicag.2007.08.001","article-title":"Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators","volume":"31","author":"EJ Giamarellos-Bourboulis","year":"2008","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/AAC.01052-10","article-title":"Anti-inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-\u03baB signaling and CXCL8 transcription","volume":"55","author":"CD Fischer","year":"2011","journal-title":"Antimicrob Agents Chemotherap"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0159219","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T14:15:02Z","timestamp":1567606502000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149100"}},"subtitle":[],"editor":[{"given":"Jordi B","family":"Torrelles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149100","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0159219","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}