{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:27:49Z","timestamp":1793042869520,"version":"4.5.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149230","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T18:37:06Z","timestamp":1455907026000},"page":"e0149230","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":81,"title":["The VITRO Score (Von Willebrand Factor Antigen\/Thrombocyte Ratio) as a New Marker for Clinically Significant Portal Hypertension in Comparison to Other Non-Invasive Parameters of Fibrosis Including ELF Test"],"prefix":"10.1371","volume":"11","author":[{"given":"Stephanie","family":"Hametner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Ferlitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ferlitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Etschmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Sch\u00f6fl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ziachehabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Maieron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1055\/s-2006-951603","article-title":"Measurement of portal pressure and its role in the management of chronic liver disease","volume":"26","author":"J Bosch","year":"2006","journal-title":"Seminars in liver disease"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/hep.24129","article-title":"Noninvasive assessment of portal hypertension in patients with cirrhosis","volume":"53","author":"D Thabut","year":"2011","journal-title":"Hepatology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2010.06.004","article-title":"Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension","volume":"53","author":"R de Franchis","year":"2010","journal-title":"Journal of hepatology"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jhep.2009.01.014","article-title":"Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis","volume":"50","author":"C Ripoll","year":"2009","journal-title":"Journal of hepatology"},{"issue":"7\u20138","key":"ref5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00508-013-0337-z","article-title":"Austrian consensus on the definition and treatment of portal hypertension and its complications (Billroth II)","volume":"125","author":"M Peck-Radosavljevic","year":"2013","journal-title":"Wiener klinische Wochenschrift"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"J Bosch","year":"2009","journal-title":"Nature reviews Gastroenterology & hepatology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/hep.21665","article-title":"Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis","volume":"45","author":"F Vizzutti","year":"2007","journal-title":"Hepatology"},{"key":"ref8","article-title":"Baseline and serial liver stiffness measurement in prediction of portal hypertension progression for patients with compensated cirrhosis","author":"JH Wang","year":"2014","journal-title":"Liver international: official journal of the International Association for the Study of the Liver"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jhep.2013.10.027","article-title":"Detection of early portal hypertension with routine data and liver stiffness in patients with asymptomatic liver disease: a prospective study","volume":"60","author":"S Augustin","year":"2014","journal-title":"Journal of hepatology"},{"key":"ref10","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension","author":"R de Franchis","year":"2015","journal-title":"Journal of hepatology"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1182\/blood.V94.1.179.413k18_179_185","article-title":"von Willebrand factor propeptide in vascular disorders: A tool to distinguish between acute and chronic endothelial cell perturbation","volume":"94","author":"JA van Mourik","year":"1999","journal-title":"Blood"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jhep.2007.02.006","article-title":"Vascular endothelial dysfunction in cirrhosis","volume":"46","author":"Y Iwakiri","year":"2007","journal-title":"J Hepatol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.21228","article-title":"The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis","volume":"44","author":"V Matei","year":"2006","journal-title":"Hepatology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/apt.12564","article-title":"Von Willebrand Factor as a new marker for non-invasive assessment of liver fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"39","author":"A Maieron","year":"2014","journal-title":"Alimentary pharmacology & therapeutics"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1538-7836.2004.00838.x","article-title":"Standardization of factor VIII and von Willebrand factor in plasma: calibration of the WHO 5th International Standard (02\/150)","volume":"2","author":"AR Hubbard","year":"2004","journal-title":"Journal of thrombosis and haemostasis: JTH"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/hep.25806","article-title":"von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis","volume":"56","author":"M Ferlitsch","year":"2012","journal-title":"Hepatology"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1136\/gut.2010.235689","article-title":"Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension","volume":"60","author":"V La Mura","year":"2011","journal-title":"Gut"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2008.03.009","article-title":"Thrombocytopenia associated with chronic liver disease","volume":"48","author":"N Afdhal","year":"2008","journal-title":"Journal of hepatology"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cgh.2009.02.021","article-title":"Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis","volume":"7","author":"AA Qamar","year":"2009","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-230X-11-44","article-title":"A comparison of four fibrosis indexes in chronic HCV: development of new fibrosis-cirrhosis index (FCI)","volume":"11","author":"W Ahmad","year":"2011","journal-title":"BMC gastroenterology"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1499-3872(13)60079-X","article-title":"Diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C","volume":"12","author":"R Catanzaro","year":"2013","journal-title":"Hepatobiliary & pancreatic diseases international: HBPD INT"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1053\/j.gastro.2009.10.058","article-title":"Peginterferon alfa-2a\/ribavirin for 48 or 72 weeks in hepatitis C genotypes 1 and 4 patients with slow virologic response","volume":"138","author":"P Ferenci","year":"2010","journal-title":"Gastroenterology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"CT Wai","year":"2003","journal-title":"Hepatology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1111\/j.1572-0241.2007.01530.x","article-title":"6-thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension","volume":"102","author":"A Ferlitsch","year":"2007","journal-title":"The American journal of gastroenterology"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.cgh.2011.03.002","article-title":"Portal pressure predicts outcome and safety of antiviral therapy in cirrhotic patients with hepatitis C virus infection","volume":"9","author":"T Reiberger","year":"2011","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/hep.25993","article-title":"Determination of reliability criteria for liver stiffness evaluation by transient elastography","volume":"57","author":"J Boursier","year":"2013","journal-title":"Hepatology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.52.3.404","article-title":"Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis","volume":"52","author":"GV Papatheodoridis","year":"2003","journal-title":"Gut"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nm1317","article-title":"Platelets mediate cytotoxic T lymphocyte-induced liver damage","volume":"11","author":"M Iannacone","year":"2005","journal-title":"Nature medicine"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/hep.510230613","article-title":"High plasma levels of von Willebrand factor as a marker of endothelial perturbation in cirrhosis: relationship to endotoxemia","volume":"23","author":"D Ferro","year":"1996","journal-title":"Hepatology"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00535-011-0517-4","article-title":"Non-selective beta-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis","volume":"47","author":"T Reiberger","year":"2012","journal-title":"Journal of gastroenterology"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3851\/IMP1654","article-title":"von Willebrand factor antigen: a novel on-treatment predictor of response to antiviral therapy in chronic hepatitis C genotypes 1 and 4","volume":"15","author":"S Pramhas","year":"2010","journal-title":"Antiviral therapy"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2036.2004.02305.x","article-title":"Short- and long-term effects of therapy with interferon-alpha and pegylated interferon-alpha\/ribavirin on platelet plug formation and von Willebrand factor release in patients with chronic hepatitis C","volume":"21","author":"M Homoncik","year":"2005","journal-title":"Alimentary pharmacology & therapeutics"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jhep.2013.03.016","article-title":"The Enhanced Liver Fibrosis (ELF) score: normal values, influence factors and proposed cut-off values","volume":"59","author":"R Lichtinghagen","year":"2013","journal-title":"Journal of hepatology"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"e51906","DOI":"10.1371\/journal.pone.0051906","article-title":"Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography","volume":"7","author":"K Wahl","year":"2012","journal-title":"PloS one"},{"key":"ref35","article-title":"New reliability criteria for transient elastography increase the number of accurate measurements for screening of cirrhosis and portal hypertension","author":"P Schwabl","year":"2014","journal-title":"Liver international: official journal of the International Association for the Study of the Liver"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T20:31:49Z","timestamp":1600201909000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149230"}},"subtitle":[],"editor":[{"given":"Erica","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149230","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}