{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:34:45Z","timestamp":1773383685600,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149427","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T19:08:13Z","timestamp":1456168093000},"page":"e0149427","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism"],"prefix":"10.1371","volume":"11","author":[{"given":"Elena","family":"Sticchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Magi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia R.","family":"Kamstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Prisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Mannuccio","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betti","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0021-9150(99)00064-7","article-title":"Atherogenecity of lipoprotein(a) and oxidized low density lipoprotein: insight from in vivo studies of arterial wall influx, degradation and efflux","volume":"143","author":"LB Nielsen","year":"1999","journal-title":"Atherosclerosis"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1172\/JCI119565","article-title":"Modification of apolipoprotein(a) lysine binding site reduces atherosclerosis in transgenic mice","volume":"100","author":"NW Boonmark","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1096\/fj.05-4857fje","article-title":"Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin","volume":"20","author":"SN Sotiriou","year":"2006","journal-title":"FASEB J"},{"issue":"23","key":"ref4","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/eurheartj\/ehq386","article-title":"European Atherosclerosis Society Consensus Panel. Lipoprotein(a) as a cardiovascular risk factor: current status","volume":"31","author":"BG Nordestgaard","year":"2010","journal-title":"Eur Heart J"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-2002-35404","article-title":"A critical evaluation of the role of Lp(a) in cardiovascular disease: can Lp(a) be useful in risk assessment?","volume":"2","author":"SM Marcovina","year":"2002","journal-title":"Semin Vasc Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijcard.2010.02.021","article-title":"Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women","volume":"150","author":"AN Qasim","year":"2011","journal-title":"Int J Cardiol"},{"issue":"Suppl B","key":"ref7","first-page":"37B","article-title":"Lipoprotein(a) and the link between atherosclerosis and thrombosis","volume":"20","author":"ML Koschinsky","year":"2004","journal-title":"Can J Cardiol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jama.2009.1063","article-title":"Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality","volume":"302","author":"S Erqou","year":"2009","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1161\/ATVBAHA.112.255521","article-title":"Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: the EPIC-Norfolk prospective population study","volume":"32","author":"D Gurdasani","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/CIRCULATIONAHA.107.715698","article-title":"Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study","volume":"117","author":"PR Kamstrup","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.atherosclerosis.2012.02.008","article-title":"Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis","volume":"222","author":"Y Momiyama","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejim.2012.08.014","article-title":"Lipoprotein (a) is independently correlated with coronary artery calcification","volume":"24","author":"M Greif","year":"2013","journal-title":"Eur J Intern Med"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2796.2012.02592.x","article-title":"Lipoprotein(a): resurrected by genetics","volume":"273","author":"F Kronenberg","year":"2013","journal-title":"J Intern Med"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jacc.2012.12.023","article-title":"Extreme lipoprotein(a) levels and improved cardiovascular risk prediction","volume":"61","author":"PR Kamstrup","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref15","first-page":"73","article-title":"Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation","volume":"82","author":"E Boerwinkle","year":"1989","journal-title":"Hum Genet"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1172\/JCI117263","article-title":"Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus","volume":"93","author":"A Gaw","year":"1994","journal-title":"J Clin Invest"},{"issue":"22","key":"ref17","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically elevated lipoprotein(a) and increased risk of myocardial infarction","volume":"301","author":"PR Kamstrup","year":"2009","journal-title":"JAMA"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.ATV.15.1.58","article-title":"C\/T polymorphism in the 5' untranslated region of the apolipoprotein(a) gene introduces an upstream ATG and reduces in vitro translation","volume":"15","author":"BR Zysow","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1172\/JCI119295","article-title":"Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region","volume":"99","author":"K Suzuki","year":"1997","journal-title":"J Clin Invest"},{"issue":"26","key":"ref20","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","article-title":"Genetic variants associated with Lp(a) lipoprotein level and coronary disease","volume":"361","author":"R Clarke","year":"2009","journal-title":"N Engl J Med"},{"issue":"Suppl 22","key":"ref21","first-page":"111","article-title":"Lipoprotein(a): an indicator of risk in thromboembolic disease?","volume":"68","author":"W M\u00e4rz","year":"1990","journal-title":"Klin Wochenschr"},{"issue":"3","key":"ref22","first-page":"225","article-title":"Lipoprotein (a), cholesterol and triglycerides in women with venous thromboembolism","volume":"11","author":"MD McColl","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood.V96.10.3364","article-title":"Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism","volume":"96","author":"M von Depka","year":"2000","journal-title":"Blood"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.amjmed.2003.06.005","article-title":"Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism","volume":"115","author":"R Marcucci","year":"2003","journal-title":"Am J Med"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.thromres.2006.03.002","article-title":"Lipoprotein (a) in patients with spontaneous venous thromboembolism","volume":"120","author":"R Vormittag","year":"2007","journal-title":"Thromb Res"},{"issue":"8","key":"ref26","first-page":"726","article-title":". Lipoprotein(a) concentration is not associated with venous thromboembolism in a case control study","volume":"84","author":"G Lippi","year":"1999","journal-title":"Haematologica"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/archinte.162.10.1182","article-title":"Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology","volume":"162","author":"AW Tsai","year":"2002","journal-title":"Arch Intern Med"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/ATVBAHA.112.248765","article-title":"Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis","volume":"32","author":"PR Kamstrup","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jacc.2012.01.078","article-title":"Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism","volume":"60","author":"A Helgadottir","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jth.12056","article-title":"Lipoprotein(a), polymorphisms in the LPA gene, and incident venous thromboembolism among 21483 women","volume":"11","author":"JS Danik","year":"2013","journal-title":"J Thromb Haemost"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1055\/s-0031-1297172","article-title":"Testing for lipoprotein(a) concentration and apolipoprotein(a) phenotypes: method standardization and pediatric reference values","volume":"37","author":"C Langer","year":"2011","journal-title":"Semin Thromb Hemost"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/ATVBAHA.112.251306","article-title":"Mechanisms of lipoprotein(a) pathogenicity: prothrombotic, proatherosclerotic, or both?","volume":"32","author":"JD Spence","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jacc.2012.04.038","article-title":"Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies","volume":"60","author":"S Tsimikas","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.amjmed.2007.01.029","article-title":". Lipoprotein (a) and venous thromboembolism in adults: a meta-analysis","volume":"120","author":"F Sofi","year":"2007","journal-title":"Am J Med"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1016\/j.thromres.2012.06.005","article-title":"Altered fibrin clot properties are associated with residual vein obstruction: effects of lipoprotein(a) and apolipoprotein(a) isoform","volume":"130","author":"A Undas","year":"2012","journal-title":"Thromb Res"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/oxfordjournals.aje.a008713","article-title":"Validated questionnaire for the identification of previous personal or familial venous thromboembolism","volume":"143","author":"M Frezzato","year":"1996","journal-title":"Am J Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ymgme.2006.12.011","article-title":"LPA +93C>T and +121G>A polymorphisms detection by electronic microchip technology","volume":"91","author":"E Sticchi","year":"2007","journal-title":"Mol Genet Metab"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1194\/jlr.D800050-JLR200","article-title":"Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR","volume":"50","author":"MB Lanktree","year":"2009","journal-title":"J Lipid Res"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1160\/TH09-11-0748","article-title":"Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism","volume":"104","author":"B Giusti","year":"2010","journal-title":"Thromb Haemost"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"ER DeLong","year":"1988","journal-title":"Biometrics"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCGENETICS.109.907642","article-title":"Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians","volume":"3","author":"MB Lanktree","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000472175","article-title":"Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-random","volume":"4","author":"HG Kraft","year":"1996","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.beha.2012.07.002","article-title":"Abdominal thromboses of splanchnic, renal and ovarian veins","volume":"25","author":"V De Stefano","year":"2012","journal-title":"Best Pract Res Clin Haematol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.atherosclerosis.2007.05.020","article-title":"Fish intake and LPA 93C>T polymorphism: gene-environment interaction in modulating lipoprotein (a) concentrations","volume":"195","author":"F Sofi","year":"2007","journal-title":"Atherosclerosis"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/hmg\/7.2.257","article-title":"Significant impact of the +93 C\/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: confounding effect of linkage disequilibrium","volume":"7","author":"HG Kraft","year":"1998","journal-title":"Hum Mol Genet"},{"issue":"1\u20132","key":"ref46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cca.2007.09.014","article-title":"The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease","volume":"387","author":"M Catalano","year":"2008","journal-title":"Clin Chim Acta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T23:18:41Z","timestamp":1600211921000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149427"}},"subtitle":[],"editor":[{"given":"Esteban","family":"G\u00e1ndara","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149427","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]}}}