{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:44:54Z","timestamp":1787967894651,"version":"build-2784847793"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149451","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T18:51:26Z","timestamp":1455303086000},"page":"e0149451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["MW151 Inhibited IL-1\u03b2 Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses"],"prefix":"10.1371","volume":"11","author":[{"given":"Adam D.","family":"Bachstetter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S.","family":"Goulding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa N.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradoldej","family":"Sompol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F.","family":"Abisambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lifshitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Martin","family":"Watterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Van Eldik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fneur.2013.00018","article-title":"The role of markers of inflammation in traumatic brain injury","volume":"4","author":"T Woodcock","year":"2013","journal-title":"Front Neurol"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.bbi.2012.06.008","article-title":"Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention","volume":"26","author":"A Kumar","year":"2012","journal-title":"Brain Behav Immun"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1523\/JNEUROSCI.0291-15.2015","article-title":"Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment","volume":"35","author":"SJ Webster","year":"2015","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12974-015-0289-5","article-title":"Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic","volume":"12","author":"AD Bachstetter","year":"2015","journal-title":"J Neuroinflammation"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"e82507","DOI":"10.1371\/journal.pone.0082507","article-title":"Diffuse brain injury induces acute post-traumatic sleep","volume":"9","author":"RK Rowe","year":"2014","journal-title":"PLoS One"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1523\/JNEUROSCI.5399-12.2013","article-title":"The p38alpha MAPK regulates microglial responsiveness to diffuse traumatic brain injury","volume":"33","author":"AD Bachstetter","year":"2013","journal-title":"J Neurosci"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1089\/neu.2007.0295","article-title":"Inflammation in human brain injury: Intracerebral concentrations of IL-1 alpha, IL-1 beta, and their endogenous inhibitor IL-1r","volume":"24","author":"PJ Hutchinson","year":"2007","journal-title":"J Neurotrauma"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1089\/neu.2007.0349","article-title":"Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: Effects of moderate hypothermia","volume":"24","author":"SDW Buttram","year":"2007","journal-title":"J Neurotrauma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/aws322","article-title":"Inflammation and white matter degeneration persist for years after a single traumatic brain injury","volume":"136","author":"VE Johnson","year":"2013","journal-title":"Brain"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: microglial activation and traumatic brain injury","volume":"70","author":"AF Ramlackhansingh","year":"2011","journal-title":"Ann Neurol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00401-001-0503-7","article-title":"CD14 expression by activated parenchymal microglia\/macrophages and infiltrating monocytes following human traumatic brain injury","volume":"103","author":"R Beschorner","year":"2002","journal-title":"Acta Neuropathol"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"e66226","DOI":"10.1371\/journal.pone.0066226","article-title":"Development of novel chemical probes to address CNS protein kinase involvement in synaptic dysfunction","volume":"8","author":"DM Watterson","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bmcl.2006.10.028","article-title":"Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits","volume":"17","author":"W Hu","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1523\/JNEUROSCI.4652-05.2006","article-title":"Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration","volume":"26","author":"Ranaivo H Ralay","year":"2006","journal-title":"J Neurosci"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1021\/acschemneuro.5b00002","article-title":"Targeting human central nervous system protein kinases: An isoform selective p38alphaMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models","volume":"6","author":"SM Roy","year":"2015","journal-title":"ACS Chem Neurosci"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1385\/JMN:24:1:115","article-title":"Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation","volume":"24","author":"JM Craft","year":"2004","journal-title":"J Mol Neurosci"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.neurobiolaging.2004.01.006","article-title":"Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo","volume":"25","author":"JM Craft","year":"2004","journal-title":"Neurobiol Aging"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/glia.20306","article-title":"Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration","volume":"53","author":"JM Craft","year":"2006","journal-title":"Glia"},{"issue":"30","key":"ref19","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1523\/JNEUROSCI.1496-12.2012","article-title":"Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology","volume":"32","author":"AD Bachstetter","year":"2012","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1742-2094-5-28","article-title":"Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury","volume":"5","author":"E Lloyd","year":"2008","journal-title":"J Neuroinflammation"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1528-1167.2007.01135.x","article-title":"Glial activation links early-life seizures and long-term neurologic dysfunction: Evidence using a small molecule inhibitor of proinflammatory cytokine upregulation","volume":"48","author":"KC Somera-Molina","year":"2007","journal-title":"Epilepsia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainres.2009.05.073","article-title":"Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model","volume":"1282","author":"KC Somera-Molina","year":"2009","journal-title":"Brain Res"},{"issue":"39","key":"ref23","doi-asserted-by":"crossref","first-page":"13077","DOI":"10.1523\/JNEUROSCI.2518-14.2014","article-title":"An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis","volume":"34","author":"SL Macauley","year":"2014","journal-title":"J Neurosci"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jneuroim.2008.06.039","article-title":"Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug","volume":"203","author":"WJ Karpus","year":"2008","journal-title":"J Neuroimmunol"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1667\/RR3026.1","article-title":"Selective inhibition of microglia-mediated neuroinflammation mitigates radiation-induced cognitive impairment","volume":"179","author":"KA Jenrow","year":"2013","journal-title":"Radiat Res"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1089\/neu.2009.1227","article-title":"Minozac treatment prevents increasedseizure susceptibility in a mouse "two-hit'' model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures","volume":"27","author":"M Chrzaszcz","year":"2010","journal-title":"J Neurotrauma"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1089\/neu.2008.0586","article-title":"Classification of traumatic brain injury for targeted therapies","volume":"25","author":"KE Saatman","year":"2008","journal-title":"J Neurotrauma"},{"issue":"7419","key":"ref28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature11556","article-title":"A call for transparent reporting to optimize the predictive value of preclinical research","volume":"490","author":"SC Landis","year":"2012","journal-title":"Nature"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/alzrt90","article-title":"Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies","volume":"3","author":"DW Shineman","year":"2011","journal-title":"Alzheimers Res Ther"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Eakin K, Rowe RK, Lifshitz J. Modeling fluid percussion injury: relevance to human traumatic brain injury. In: Kobeissy FHP, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Frontiers in Neuroengineering. Boca Raton (FL)2015.","DOI":"10.1201\/b18126-23"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.neurobiolaging.2009.11.022","article-title":"Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats","volume":"32","author":"AD Bachstetter","year":"2011","journal-title":"Neurobiol Aging"},{"issue":"2\u20133","key":"ref32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"E Blasi","year":"1990","journal-title":"J Neuroimmunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1742-2094-8-79","article-title":"Microglial p38alpha MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Abeta)","volume":"8","author":"AD Bachstetter","year":"2011","journal-title":"J Neuroinflammation"},{"issue":"13","key":"ref34","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.5103-10.2011","article-title":"Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal population","volume":"31","author":"JE Greer","year":"2011","journal-title":"J Neurosci"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00401-013-1119-4","article-title":"Mild traumatic brain injury in the mouse induces axotomy primarily within the axon initial segment","volume":"126","author":"JE Greer","year":"2013","journal-title":"Acta Neuropathol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/ALN.0b013e318253a02a","article-title":"TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice","volume":"116","author":"ML James","year":"2012","journal-title":"Anesthesiology"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1401867","article-title":"Mechanisms of Jak\/STAT Signaling in Immunity and Disease","volume":"194","author":"AV Villarino","year":"2015","journal-title":"Journal of Immunology"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"H Yu","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrc3611","article-title":"Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms","volume":"13","author":"E Elinav","year":"2013","journal-title":"Nat Rev Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:43:17Z","timestamp":1540298597000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149451"}},"subtitle":[],"editor":[{"given":"Cesar V","family":"Borlongan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149451","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}