{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:11:16Z","timestamp":1780639876413,"version":"3.54.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149518","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T13:45:18Z","timestamp":1456839918000},"page":"e0149518","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia"],"prefix":"10.1371","volume":"11","author":[{"given":"Nobuto","family":"Tsuneyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Sugai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/oxfordjournals.schbul.a006986","article-title":"The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development","volume":"29","author":"TS Stroup","year":"2003","journal-title":"Schizophr Bull"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"JA Lieberman","year":"2005","journal-title":"N Engl J Med"},{"issue":"2\u20133","key":"ref3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.schres.2010.07.012","article-title":"Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis","volume":"123","author":"C Rummel-Kluge","year":"2010","journal-title":"Schizophr Res"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2165\/00023210-200721110-00004","article-title":"Adverse effects of atypical antipsychotics: differential risk and clinical implications","volume":"21","author":"PM Haddad","year":"2007","journal-title":"CNS Drugs"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-244X-8-78","article-title":"Early evaluation of patient risk for substantial weight gain during olanzapine treatment for schizophrenia, schizophreniform, or schizoaffective disorder","volume":"8","author":"I Lipkovich","year":"2008","journal-title":"BMC Psychiatry"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2165\/11596300-000000000-00000","article-title":"Atypical antipsychotic-induced weight gain: insights into mechanisms of action","volume":"25","author":"JL Roerig","year":"2011","journal-title":"CNS Drugs"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.npep.2015.04.001","article-title":"Effect of short and long-term treatment with antipsychotics on orexigenic\/anorexigenic neuropeptides expression in the rat hypothalamus","volume":"51","author":"E Rojczyk","year":"2015","journal-title":"Neuropeptides"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"T47","DOI":"10.1530\/JOE-13-0339","article-title":"Adipocytokines in obesity and metabolic disease","volume":"220","author":"H Cao","year":"2014","journal-title":"J Endocrinol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"E567","DOI":"10.1152\/ajpendo.00315.2011","article-title":"Leptin in human physiology and pathophysiology","volume":"301","author":"CS Mantzoros","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"C Weyer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm1029","article-title":"Adiponectin acts in the brain to decrease body weight","volume":"10","author":"Y Qi","year":"2004","journal-title":"Nat Med"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00004714-199610000-00011","article-title":"Effects of clozapine on plasma cytokine and soluble cytokine receptor levels","volume":"16","author":"T Pollm\u00e4cher","year":"1996","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.psyneuen.2008.08.016","article-title":"Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever","volume":"34","author":"M Kluge","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/JCP.0b013e3182524393","article-title":"Dysregulation of adipocytokines related to second-generation antipsychotics in normal fasting glucose patients with schizophrenia","volume":"32","author":"T Sugai","year":"2012","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/JCP.0b013e318221e80d","article-title":"Changes in the metabolic parameters and QTc interval after switching from olanzapine to aripiprazole in Japanese patients with stable schizophrenia","volume":"31","author":"Y Suzuki","year":"2011","journal-title":"J Clin Psychopharmacol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000099945","article-title":"Rapid leptin elevation after initiation of olanzapine?","volume":"54","author":"HC Wang","year":"2006","journal-title":"Neuropsychobiology"},{"issue":"5223","key":"ref17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"JL Halaas","year":"1995","journal-title":"Science"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.schres.2004.10.012","article-title":"The soluble leptin receptor in olanzapine-induced weight gain: results from a prospective study","volume":"75","author":"C Ebenbichler","year":"2005","journal-title":"Schizophr Res"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00004714-200208000-00015","article-title":"Pronounced early increase in circulating leptin predicts a lower weight gain during clozapine treatment","volume":"22","author":"P Monteleone","year":"2002","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/JCP.0b013e3180cac8db","article-title":"Sex difference in effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia","volume":"27","author":"RR Wu","year":"2007","journal-title":"J Clin Psychopharmacol"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4088\/JCP.v68n1120","article-title":"Effect of olanzapine, risperidone, and haloperidol treatment on weight and body mass index in first-episode schizophrenia patients in India: a randomized, double-blind, controlled, prospective study","volume":"68","author":"S Saddichha","year":"2007","journal-title":"J Clin Psychiatry"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jpsychires.2008.11.001","article-title":"Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course","volume":"43","author":"S Gebhardt","year":"2009","journal-title":"J Psychiatr Res"},{"issue":"1\u20132","key":"ref23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0920-9964(02)00431-0","article-title":"Weight gain in patients with schizophrenia treated with risperidone, olanzapine, quetiapine or haloperidol: results of the EIRE study","volume":"62","author":"J Bobes","year":"2003","journal-title":"Schizophr Res"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4088\/JCP.v66n1118","article-title":"Long-term weight gain in patients treated with open-label olanzapine in combination with fluoxetine for major depressive disorder","volume":"66","author":"SW Andersen","year":"2005","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/oby.2006.6","article-title":"Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents","volume":"14","author":"VL Albaugh","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.lfs.2007.08.009","article-title":"Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats","volume":"81","author":"S Choi","year":"2007","journal-title":"Life Sci"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-011-2555-2","article-title":"Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters","volume":"221","author":"KJ Davey","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2337\/diabetes.52.3.682","article-title":"Differential sensitivity to central leptin and insulin in male and female rats","volume":"52","author":"DJ Clegg","year":"2003","journal-title":"Diabetes"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/joe.0.1760313","article-title":"Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: peripubertal changes and the emergence of sex differences","volume":"176","author":"JT Smith","year":"2003","journal-title":"J Endocrinol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcn\/80.2.430","article-title":"Sex differences in resting energy expenditure and their relation to insulin resistance in children (EarlyBird 13)","volume":"80","author":"J Kirkby","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ajcn\/79.3.385","article-title":"Effects of the interaction of sex and food intake on the relation between energy expenditure and body composition","volume":"79","author":"DR Paul","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4088\/JCP.v65n0620","article-title":"Atypical antipsychotics and weight gain in Chinese patients: a comparison of olanzapine and risperidone","volume":"65","author":"E Lee","year":"2004","journal-title":"J Clin Psychiatry"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4088\/JCP.13m08400","article-title":"A gender analysis of the study of pharmacotherapy of psychotic depression (STOP-PD): gender and age as predictors of response and treatment-associated changes in body mass index and metabolic measures","volume":"74","author":"KM Deligiannidis","year":"2013","journal-title":"J Clin Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:35:43Z","timestamp":1567643743000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149518"}},"subtitle":[],"editor":[{"given":"Susanne","family":"Kaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149518","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}