{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:53:27Z","timestamp":1773705207836,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149629","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T18:58:03Z","timestamp":1456167483000},"page":"e0149629","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of TLR4 and Treg in Helicobacter pylori Colonization and Inflammation in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Yanfeng","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanjin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"ref1","first-page":"115","article-title":"Helicobacter pylori vaccine: mucosal adjuvant &amp; delivery systems","volume":"130","author":"H Sijun","year":"2009","journal-title":"Indian J Med Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"T Kawasaki","year":"2014","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/MOG.0b013e32833f1222","article-title":"Gastroduodenal mucosal defense","volume":"26","author":"A deFoneska","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4291\/wjgp.v5.i3.133","article-title":"Role of Toll-like receptors in Helicobacter pylori infection and immunity","volume":"5","author":"SM Smith","year":"2004","journal-title":"World J Gastrointest Pathophysiol"},{"key":"ref5","first-page":"6950","article-title":"Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis","volume":"7","author":"TR Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1089\/gtmb.2014.0047","article-title":"Effect of the -2081G\/A polymorphism of the TLR4 gene and its interaction with Helicobacter pylori infection on the risk of gastric cancer in Chinese individuals","volume":"18","author":"P LI","year":"2014","journal-title":"Genet Test Mol Biomarkers"},{"key":"ref7","first-page":"190","article-title":"Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection","volume":"48","author":"T Kawahara","year":"2001","journal-title":"J Med Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1111\/j.1462-5822.2007.00935.x","article-title":"Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2\/1\/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells","volume":"9","author":"M Triantafilou","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-94-017-9487-9_4","article-title":"Regulatory T-cell differentiation and their function in immune regulation","volume":"841","author":"M Piccioni","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.transproceed.2010.07.039","article-title":"Immunoregulation and tolerance","volume":"42","author":"SJ Knechtle","year":"2010","journal-title":"Transplant Proc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.semcancer.2005.11.004","article-title":"Functional control of regulatory T cells and cancer immunotherapy","volume":"16","author":"RF Wang","year":"2006","journal-title":"Semin Cancer Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/IAI.73.1.523-531.2005","article-title":"Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients","volume":"73","author":"A Lundgren","year":"2005","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2249.2003.02177.x","article-title":"Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice","volume":"132","author":"S Raghavan","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1172\/JCI25439","article-title":"Toll-like receptor 2 controls expansion and function of regulatory T cells","volume":"116","author":"RP Sutmuller","year":"2006","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1189\/jlb.3A0114-056RR","article-title":"TLR4 regulates IFN-\u03b3 and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation","volume":"96","author":"AT Cao","year":"2014","journal-title":"J Leukoc Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1189\/jlb.0413209","article-title":"Flagellin and LPS each restores rat lymphocyte populations after colorectal irradiation","volume":"95","author":"JV Lacave-Lapalun","year":"2014","journal-title":"J Leukoc Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.4049\/jimmunol.174.5.2957","article-title":"CD4+CD25+ regulatory T cells control innate immune reactivity after injury","volume":"174","author":"TJ Murphy","year":"2005","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4049\/jimmunol.1203334","article-title":"Targeting of TLRs inhibits CD4+ regulatory T cell function and activates lymphocytes in human peripheral blood mononuclear cells","volume":"193","author":"KS Voo","year":"2014","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/SHK.0b013e318296e65b","article-title":"CD4+CD25+ regulatory T cells attenuate lipopolysaccharide-induced systemic inflammatory responses and promotes survival in murine Escherichia coli infection","volume":"40","author":"EB Okeke","year":"2013","journal-title":"Shock"},{"key":"ref20","first-page":"469","article-title":"Changes of FoxP3, CD4(+)CD25(+) regulatory T cells, TLR2 and TLR9 in children with infectious mononucleosis","volume":"21","author":"Q Wang","year":"2013","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e104804","DOI":"10.1371\/journal.pone.0104804","article-title":"Involvement of Toll-like receptors on Helicobacter pylori-induced immunity","volume":"9","author":"R K\u00e4bisch","year":"2014","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"13082","DOI":"10.1128\/JVI.78.23.13082-13089.2004","article-title":"CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1","volume":"78","author":"FN Toka","year":"2004","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.mpa.0000175179.62916.17","article-title":"Roles of endotoxin-related signaling molecules in the progression of acute necrotizing pancreatitis in mice","volume":"31","author":"X Wang","year":"2005","journal-title":"Pancreas"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.gtc.2011.03.002","article-title":"A global perspective on gastrointestinal diseases","volume":"40","author":"R Menon","year":"2011","journal-title":"Gastroenterol Clin North Am"},{"key":"ref25","first-page":"220","article-title":"Anti-Helicobacter pylori effect and regulation of T helper response of chitosan","volume":"46","author":"Y Xie","year":"2007","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3748\/wjg.v13.i10.1547","article-title":"The immune response induced by H. pylori vaccine with chitosan as adjuvant and its relation to immune protection","volume":"13","author":"Y Xie","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/hel.12156","article-title":"Immunity, inflammation, and vaccines for Helicobacter pylori","volume":"19","author":"MM D'Elios","year":"2014","journal-title":"Helicobacter"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.4049\/jimmunol.1302865","article-title":"Cytokine BAFF released by Helicobacter pylori-infected macrophages triggers the Th17 response in human chronic gastritis","volume":"193","author":"F Munari","year":"2014","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/j.gastro.2007.04.071","article-title":"Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunityto Helicobacter pylori","volume":"133","author":"R Rad","year":"2007","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1146\/annurev-biochem-052909-141507","article-title":"Structural biology of the Toll-like receptor family","volume":"80","author":"JY Kang","year":"2011","journal-title":"Annu Rev Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11427-010-0011-x","article-title":"Regulation of Toll-like receptor signaling in the innate immunity","volume":"53","author":"H An","year":"2010","journal-title":"Sci China Life Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/hel.12067","article-title":"Toll-like receptors and cytokines are upregulated during Helicobacter pylori infection in children","volume":"18","author":"H Lagunes-Servin","year":"2013","journal-title":"Helicobacter"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e74595","DOI":"10.1371\/journal.pone.0074595","article-title":"TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice","volume":"8","author":"X Sun","year":"2013","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/IAI.01344-13","article-title":"Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy","volume":"82","author":"A Banerjee","year":"2014","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.3892\/mmr.2015.3950","article-title":"Chitosan as an adjuvant for a Helicobacter pylori therapeutic vaccine","volume":"12","author":"Y Gong","year":"2015","journal-title":"Molecular Medicine Reports"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/j.gastro.2006.05.001","article-title":"CD25+\/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo","volume":"131","author":"R Rad","year":"2006","journal-title":"Gastroenterology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T21:41:36Z","timestamp":1567633296000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149629"}},"subtitle":[],"editor":[{"given":"Yoshio","family":"Yamaoka","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149629","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]}}}