{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:13:08Z","timestamp":1790439188118,"version":"4.1.0"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149663","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T19:07:32Z","timestamp":1456859252000},"page":"e0149663","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration"],"prefix":"10.1371","volume":"11","author":[{"given":"Liyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lue","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prahatha","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leelyn","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Bing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Pui","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Ming","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Fai","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrg2717","article-title":"Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait","volume":"11","author":"AF Wright","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.preteyeres.2010.03.004","article-title":"The molecular basis of human retinal and vitreoretinal diseases","volume":"29","author":"W Berger","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1074\/jbc.R111.304428","article-title":"Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?","volume":"287","author":"C Punzo","year":"2012","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1073\/pnas.0604056103","article-title":"Antioxidants reduce cone cell death in a model of retinitis pigmentosa","volume":"103","author":"K Komeima","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.21152","article-title":"Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa","volume":"213","author":"K Komeima","year":"2007","journal-title":"J Cell Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/APO.0b013e31827a9969","article-title":"Drug Screening to Treat Early-Onset Eye Diseases : Can Zebrafish Expedite the Discovery ?","volume":"1","author":"L Zhang","year":"2012","journal-title":"Asia-Pac J Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.expneurol.2006.05.031","article-title":"Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma","volume":"203","author":"H-C Chan","year":"2007","journal-title":"Exp Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e16380","DOI":"10.1371\/journal.pone.0016380","article-title":"Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia\/reperfusion injury","volume":"6","author":"S-Y Li","year":"2011","journal-title":"PLoS One"},{"key":"ref9","first-page":"289","article-title":"Schisandrin B and other Dibenzocyclooctadiene lignans","author":"KM Ko","year":"2004","journal-title":"Herbal and Traditional Medicine: Molecular Aspects of Health"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.lfs.2008.03.006","article-title":"Schisandrin B stereoisomers protect against hypoxia\/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes","volume":"82","author":"PY Chiu","year":"2008","journal-title":"Life Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/B:MCBI.0000049151.79238.30","article-title":"Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats","volume":"266","author":"PY Chiu","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/biof.5520190106","article-title":"Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury","volume":"19","author":"PY Chiu","year":"2003","journal-title":"Biofactors"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1023\/A:1006927926495","article-title":"Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status","volume":"196","author":"TK Yim","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11010-010-0703-3","article-title":"Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK\/Nrf2 pathway in H9c2 cells","volume":"350","author":"PY Chiu","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.canlet.2006.03.009","article-title":"Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1","volume":"246","author":"M Sun","year":"2007","journal-title":"Cancer Lett"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2005.07.097","article-title":"Schisandrin B\u2014a novel inhibitor of P-glycoprotein","volume":"335","author":"P Qiangrong","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bcp.2005.11.026","article-title":"Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells","volume":"71","author":"L Li","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1093\/nar\/gkp593","article-title":"Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response","volume":"37","author":"H Nishida","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2007.08.002","article-title":"Zebrafish: a model system for the study of eye genetics","volume":"27","author":"JM Fadool","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/mrd.20831","article-title":"Zebrafish mutants as models for congenital ocular disorders in humans","volume":"75","author":"JM Gross","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/bdrc.20211","article-title":"The genetics of ocular disorders: insights from the zebrafish","volume":"93","author":"AC Morris","year":"2011","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"13866","DOI":"10.1523\/JNEUROSCI.3136-07.2007","article-title":"A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish","volume":"27","author":"G Stearns","year":"2007","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1523\/JNEUROSCI.5019-09.2010","article-title":"Wild-type cone photoreceptors persist despite neighboring mutant cone degeneration","volume":"30","author":"A Lewis","year":"2010","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1073\/pnas.0907720106","article-title":"A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene","volume":"106","author":"B Chang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ajhg.2009.06.016","article-title":"Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders","volume":"85","author":"AAHJ Thiadens","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1167\/iovs.10-5680","article-title":"Progressive loss of cones in achromatopsia: an imaging study using spectral-domain optical coherence tomography","volume":"51","author":"AAHJ Thiadens","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/hmg\/ddq517","article-title":"Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia","volume":"20","author":"T Grau","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref28","article-title":"Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish","author":"IA Viringipurampeer","year":"2014","journal-title":"Cell Death Differ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/exer.2002.1155","article-title":"Cell death in retinitis pigmentosa: gap junctions and the \u201cbystander\u201d effect","volume":"74","author":"H Ripps","year":"2002","journal-title":"Exp Eye Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"19126","DOI":"10.1073\/pnas.0709337104","article-title":"OFF ganglion cells cannot drive the optokinetic reflex in zebrafish","volume":"104","author":"F Emran","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","first-page":"923","article-title":"A behavioral assay to measure responsiveness of zebrafish to changes in light intensities","author":"F Emran","year":"2008","journal-title":"J Vis Exp"},{"key":"ref32","author":"M Westerfield","year":"2000"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/zeb.2010.0652","article-title":"A convenient dry feed for raising zebrafish larvae","volume":"7","author":"MR Hensley","year":"2010","journal-title":"Zebrafish"},{"key":"ref34","first-page":"xviii","author":"C Nusslein-Volhard","year":"2002"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1021\/ie071317b","article-title":"Separation and Purification of Schisandrin B from Fructus Schisandrae","volume":"47","author":"KF Luk","year":"2008","journal-title":"Ind Eng Chem Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/JB.110.1.155-160.1972","article-title":"Glucose-6-phosphate dehydrogenase from Escherichia coli and from a \u201chigh-level\u201d mutant","volume":"110","author":"S Banerjee","year":"1972","journal-title":"J Bacteriol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/nprot.2006.255","article-title":"Measuring the optokinetic response of zebrafish larvae","volume":"1","author":"SE Brockerhoff","year":"2006","journal-title":"Nat Protoc"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1073\/pnas.0914718107","article-title":"Zebrafish larvae lose vision at night","volume":"107","author":"F Emran","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","first-page":"2028","article-title":"Microdissection of zebrafish embryonic eye tissues","author":"L Zhang","year":"2010","journal-title":"J Vis Exp"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/zeb.2005.2.269","article-title":"Gene Expression Profiling of Zebrafish Embryonic Retina","volume":"2","author":"YF Leung","year":"2005","journal-title":"Zebrafish"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e56108","DOI":"10.1371\/journal.pone.0056108","article-title":"The role of egr1 in early zebrafish retinogenesis","volume":"8","author":"L Zhang","year":"2013","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nbt.1612","article-title":"V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets","volume":"28","author":"H Peng","year":"2010","journal-title":"Nat Biotechnol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nprot.2014.011","article-title":"Extensible visualization and analysis for multidimensional images using Vaa3D","volume":"9","author":"H Peng","year":"2014","journal-title":"Nat Protoc"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/bioinformatics\/btt276","article-title":"TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization","volume":"29","author":"J Ollion","year":"2013","journal-title":"Bioinformatics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1214\/aoms\/1177732979","article-title":"The generalization of Student\u2019s ratio","volume":"2","author":"H Hotelling","year":"1931","journal-title":"Ann Math Stat"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"Article32","DOI":"10.2202\/1544-6115.1175","article-title":"A shrinkage approach to large-scale covariance matrix estimation and implications for functional genomics","volume":"4","author":"J Sch\u00e4fer","year":"2005","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e0139521","DOI":"10.1371\/journal.pone.0139521","article-title":"Statistical Analysis of Zebrafish Locomotor Response","volume":"10","author":"Y Liu","year":"2015","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1006\/dbio.1996.0335","article-title":"The development of vision in the zebrafish (Danio rerio)","volume":"180","author":"SS Easter Jr.","year":"1996","journal-title":"Dev Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1098-2302(199712)31:4<267::AID-DEV4>3.0.CO;2-P","article-title":"The development of eye movements in the zebrafish (Danio rerio)","volume":"31","author":"SS Easter","year":"1997","journal-title":"Dev Psychobiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e36145","DOI":"10.1371\/journal.pone.0036145","article-title":"The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination","volume":"7","author":"Y Zhang","year":"2012","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e40132","DOI":"10.1371\/journal.pone.0040132","article-title":"Phenylthiourea specifically reduces zebrafish eye size","volume":"7","author":"Z Li","year":"2012","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1073\/pnas.90.18.8484","article-title":"Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene","volume":"90","author":"PC Huang","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/OPX.0b013e3181c9132b","article-title":"Mechanisms of photoreceptor death during retinal degeneration","volume":"87","author":"EL Fletcher","year":"2010","journal-title":"Optom Vis Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.preteyeres.2004.08.002","article-title":"Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration","volume":"24","author":"A Wenzel","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.neuroscience.2006.12.034","article-title":"Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration","volume":"145","author":"MM Sanz","year":"2007","journal-title":"Neuroscience"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.cub.2012.08.016","article-title":"Deep Brain Photoreceptors Control Light-Seeking Behavior in Zebrafish Larvae","volume":"22","author":"AM Fernandes","year":"2012","journal-title":"Curr Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0952523813000187","article-title":"The effects of nicotine on cone and rod b-wave responses in larval zebrafish","volume":"30","author":"M Moyano","year":"2013","journal-title":"Vis Neurosci"},{"key":"ref58","first-page":"998","article-title":"Understanding the contribution of photoreceptors to the Visual Motor Response","volume":"56","author":"P Venkatraman","year":"2015","journal-title":"Invest Ophthalmol Vis Sci. The Association for Research in Vision and Ophthalmology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vascn.2013.09.002","article-title":"Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response","volume":"69","author":"S Deeti","year":"2014","journal-title":"J Pharmacol Toxicol Methods"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"J Rihel","year":"2010","journal-title":"Science"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/dneu.20910","article-title":"Behavioral screening for neuroactive drugs in zebrafish","volume":"72","author":"J Rihel","year":"2012","journal-title":"Dev Neurobiol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0154552","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T23:01:36Z","timestamp":1654470096000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149663"}},"subtitle":[],"editor":[{"given":"Hemant","family":"Khanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149663","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}