{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:11:49Z","timestamp":1773227509479,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0149768","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T14:44:27Z","timestamp":1457534667000},"page":"e0149768","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients"],"prefix":"10.1371","volume":"11","author":[{"given":"Marcel","family":"Hoppentocht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onno W.","family":"Akkerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hagedoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Willem C.","family":"Alffenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjip S.","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huib A. M.","family":"Kerstjens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henderik W.","family":"Frijlink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne H.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1752-699X.2009.00131.x","article-title":"Bronchiectasis: an update","volume":"3","author":"M Pappalettera","year":"2009","journal-title":"Clin Respir J. Blackwell Publishing Ltd"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1164\/ajrccm.164.9.2105083","article-title":"Bronchial inflammation and colonization in patients with clinically stable bronchiectasis","volume":"164","author":"J Angrill","year":"2001","journal-title":"Am J Respir Crit Care Med. American Thoracic SocietyNew York, NY"},{"key":"ref3","first-page":"67","article-title":"Immunomodulatory effects of macrolide antibiotics\u2014part 1: biological mechanisms","volume":"81","author":"J Altenburg","year":"2011","journal-title":"Respiration. Karger Publishers"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/thorax.57.1.15","article-title":"Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors","volume":"57","author":"J Angrill","year":"2002","journal-title":"Thorax"},{"key":"ref5","first-page":"955","article-title":"Clinical, Pathophysiologic, and Microbiologic Characterization of Bronchiectasis in an Aging Cohort","volume":"108","author":"MB Nicotra","year":"1995","journal-title":"CHEST J. American College of Chest Physicians"},{"key":"ref6","first-page":"1594","article-title":"The Effect of Pseudomonas aeruginosa Infection on Clinical Parameters in Steady-State Bronchiectasis","volume":"114","author":"P Ho","year":"1998","journal-title":"CHEST J. American College of Chest Physicians"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/thx.52.3.260","article-title":"Effects of airway infection by Pseudomonas aeruginosa: A computed tomographic study","volume":"52","author":"KA Miszkiel","year":"1997","journal-title":"Thorax"},{"key":"ref8","article-title":"Correlation of CT findings with clinical evaluations in 261 patients with symptomatic bronchiectasis","author":"DA Lynch","year":"2013","journal-title":"American Public Health Association"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1183\/09031936.97.10081754","article-title":"Effect of sputum bacteriology on the quality of life of patients with bronchiectasis","volume":"10","author":"CB Wilson","year":"1997","journal-title":"Eur Respir J"},{"issue":"Suppl 1","key":"ref10","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2010.136119","article-title":"British Thoracic Society guideline for non-CF bronchiectasis","volume":"65","author":"MC Pasteur","year":"2010","journal-title":"Thorax"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ppul.1950070110","article-title":"Long-term effects of inhaled tobramycin in patients with cystic fibrosis colonized with Pseudomonas aeruginosa","volume":"7","author":"IB Maclusky","year":"1989","journal-title":"Pediatr Pulmonol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ppul.1950070413","article-title":"Safety of aerosol tobramycin administration for 3 months to patients with cystic fibrosis","volume":"7","author":"AL Smith","year":"1989","journal-title":"Pediatr Pulmonol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ppul.1950060207","article-title":"Long-term tobramycin aerosol therapy in cystic fibrosis","volume":"6","author":"G Steinkamp","year":"1989","journal-title":"Pediatr Pulmonol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1874306401509010030","article-title":"Evidence of inhaled tobramycin in non-cystic fibrosis bronchiectasis","volume":"9","author":"M Vendrell","year":"2015","journal-title":"Open Respir Med J"},{"key":"ref15","first-page":"307","article-title":"Novel tobramycin inhalation powder in cystic fibrosis subjects: Pharmacokinetics and safety","volume":"42","author":"DE Geller","year":"2007","journal-title":"Pediatr Pulm. Wiley Subscription Services, Inc., A Wiley Company"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejpb.2013.10.019","article-title":"Developments and strategies for inhaled antibiotic drugs in tuberculosis therapy: A critical evaluation","volume":"86","author":"M Hoppentocht","year":"2013","journal-title":"Eur J Pharm Biopharm"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejpb.2015.01.012","article-title":"The Cyclops for pulmonary delivery of aminoglycosides; a new member of the Twincer\u2122<\/sup> family","volume":"90","author":"M Hoppentocht","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"ref18","unstructured":"TOBI Podhaler 28 mg inhalation powder, hard capsules\u2014Summary of Product Characteristics (SPC)\u2014(eMC) [Internet]. [cited 20 Mar 2015]. Available: http:\/\/www.medicines.org.uk\/emc\/medicine\/24989\/SPC\/TOBI+Podhaler+28+mg+inhalation+powder,+hard+capsules<\/ext-link>"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.17145\/jab.15.020","article-title":"Optimisation of the sensitivity of an immunoassay analysis for tobramycin in serum","volume":"1","author":"M Hoppentocht","year":"2015","journal-title":"J Appl Bioanal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0010-4825(92)90011-B","article-title":"MW\/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring","volume":"22","author":"JH Proost","year":"1992","journal-title":"Comput Biol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcf.2010.10.003","article-title":"Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial","volume":"10","author":"MW Konstan","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref22","first-page":"230","article-title":"Tobramycin inhalation powder for P. aeruginosa infection in cystic fibrosis: The EVOLVE trial","author":"MW Konstan","year":"2010","journal-title":"Pediatr Pulm. Wiley Subscription Services, Inc., A Wiley Company"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1164\/ajrccm.162.2.9910086","article-title":"Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis","volume":"162","author":"AF Barker","year":"2000","journal-title":"Am J Respir Crit Care Med. American Thoracic SocietyNew York, NY"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jcf.2003.12.005","article-title":"Effect of nebulized colistin sulphate and colistin sulphomethate on lung function in patients with cystic fibrosis: a pilot study","volume":"3","author":"EM Westerman","year":"2004","journal-title":"J Cyst Fibros"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1378\/chest.130.5.1503","article-title":"Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis","volume":"130","author":"D Bilton","year":"2006","journal-title":"Chest"},{"key":"ref26","first-page":"1420","article-title":"A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis","volume":"127","author":"P Scheinberg","year":"2005","journal-title":"Chest"},{"key":"ref27","first-page":"360","article-title":"Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers","volume":"124","author":"MT Newhouse","year":"2003","journal-title":"Chest. American College of Chest Physicians"},{"issue":"Suppl 2","key":"ref28","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1089\/jamp.2010.0836","article-title":"The particle has landed\u2014characterizing the fate of inhaled pharmaceuticals","volume":"23","author":"JS Patton","year":"2010","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMra012519","article-title":"Bronchiectasis","volume":"346","author":"AF Barker","year":"2002","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1046\/j.1365-2125.2003.01892.x","article-title":"Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications","volume":"56","author":"NR Labiris","year":"2003","journal-title":"Br J Clin Pharmacol. Blackwell Science Ltd"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-59745-139-0","article-title":"CT of the Airways","author":"PM Boiselle","year":"2008"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1378\/chest.75.6.675","article-title":"The concentration of tobramycin in bronchial secretions","volume":"75","author":"MR Alexander","year":"1979","journal-title":"Chest"},{"key":"ref33","first-page":"545","article-title":"Penetration of gentamicin into the alveolar lining fluid of critically ill patients with ventilator-associated pneumonia","volume":"128","author":"D Panidis","year":"2005","journal-title":"Chest. American College of Chest Physicians"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0149768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:13:24Z","timestamp":1588965204000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0149768"}},"subtitle":[],"editor":[{"given":"D William","family":"Cameron","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0149768","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}