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Available: http:\/\/www.phqscreeners.com\/pdfs\/02_PHQ-9\/PHQ9_Portuguese%20for%20Brazil.pdf<\/ext-link>"},{"issue":"3","key":"ref32","first-page":"126","article-title":"Reliability of reported stressful life events reported in a self-administered questionnaire: Pro-Saude study","volume":"23","author":"CS Lopes","year":"2001","journal-title":"Revista Brasileira de Psiquiatria"},{"key":"ref33","unstructured":"Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG, Monteiro MG. AUDIT: Cuestionario de Identificaci\u00f3n de los Transtornos debidos al Consumo de Alcohol: Pautas para su utilizaci\u00f3n en Atenci\u00f3n Primaria. 2001. Available: http:\/\/www.who.int\/substance_abuse\/activities\/en\/AUDITmanualSpanish.pdf<\/ext-link>"},{"key":"ref34","unstructured":"M\u00e9ndez EB. Uma vers\u00e3o brasileira do AUDIT (Alcohol Use Disorders Identification Test). 1999. 121f. Disserta\u00e7\u00e3o [Mestrado]. Programa de P\u00f3s-Gradua\u00e7\u00e3o em Epidemiologia. Universidade Federal de Pelotas. 1999. Available: http:\/\/www.epidemio-ufpel.org.br\/uploads\/teses\/Brod%20Mendez%201999%20Dissert.pdf<\/ext-link>"},{"key":"ref35","author":"BK Becker","year":"2009"},{"key":"ref36","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE). S\u00edntese de Indicadores Sociais:Uma an\u00e1lise das condi\u00e7\u00f5es de vida da popula\u00e7\u00e3o brasileira. Rio de Janeiro: 2014. 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Bromet","year":"2011","journal-title":"BMC Medicine"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/NMD.0b013e318199f77b","article-title":"Stressful Life Events, Chronic Difficulties, and the Symptoms of Clinical Depression","volume":"197","author":"KA Muscatell","year":"2009","journal-title":"J Nerv Ment Dis"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/archgenpsychiatry.2010.136","article-title":"Dependent Stressful Life Events and Prior Depressive Episodes in the Prediction of Major Depression","volume":"67","author":"KS Kendler","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1590\/S0102-311X2003000600015","article-title":"Eventos de vida produtores de estresse e transtornos mentais comuns: resultados do Estudo Pr\u00f3-Sa\u00fade","volume":"19","author":"CS Lopes","year":"2003","journal-title":"Cad 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