{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:28:00Z","timestamp":1778718480148,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150064","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T18:40:54Z","timestamp":1457721654000},"page":"e0150064","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression"],"prefix":"10.1371","volume":"11","author":[{"given":"Sathidpak","family":"Nantasanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilda J. M.","family":"Toussaint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh A.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C. J.","family":"Tooten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"de Bruin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"ref1","author":"AF Nassar","year":"2009"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258794","article-title":"The Biology of Cancer","author":"RA Weinberg","year":"2013"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"e26019","DOI":"10.1371\/journal.pone.0026019","article-title":"The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway","volume":"6","author":"MT Saenz Robles","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/j.gastro.2011.06.046","article-title":"RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage","volume":"141","author":"AK McClendon","year":"2011","journal-title":"Gastroenterology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/humu.10176","article-title":"TP53 and liver carcinogenesis","volume":"21","author":"F Staib","year":"2003","journal-title":"Hum Mutat"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","volume":"132","author":"HB El-Serag","year":"2007","journal-title":"Gastroenterology"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrc1934","article-title":"Hepatocellular carcinoma pathogenesis: from genes to environment","volume":"6","author":"PA Farazi","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/138920211795564359","article-title":"Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review","volume":"12","author":"N Nishida","year":"2011","journal-title":"Curr Genomics"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrc2718","article-title":"p53 and E2f: partners in life and death","volume":"9","author":"S Polager","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nrc950","article-title":"The retinoblastoma tumour suppressor in development and cancer","volume":"2","author":"M Classon","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"17","key":"ref11","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/sj.onc.1208619","article-title":"Pocket proteins and cell cycle control","volume":"24","author":"D Cobrinik","year":"2005","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fonc.2014.00285","article-title":"p53 Family and Cellular Stress Responses in Cancer","volume":"4","author":"J Pflaum","year":"2014","journal-title":"Front Oncol"},{"issue":"16","key":"ref13","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.3748\/wjg.v13.i16.2271","article-title":"Genetics of hepatocellular carcinoma","volume":"13","author":"A Teufel","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathol.4.110807.092202","article-title":"Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer","volume":"4","author":"DR McGivern","year":"2009","journal-title":"Annu Rev Pathol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2353\/ajpath.2007.061133","article-title":"A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis","volume":"171","author":"P Fickert","year":"2007","journal-title":"Am J Pathol"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/dvg.20568","article-title":"Cre activity in fetal albCre mouse hepatocytes: Utility for developmental studies","volume":"47","author":"CM Weisend","year":"2009","journal-title":"Genesis"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/bfgp\/elq017","article-title":"Applications of the site-specific recombinase Cre to the study of genomic imprinting","volume":"9","author":"R Oh-McGinnis","year":"2010","journal-title":"Brief Funct Genomics"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V","article-title":"DNA excision in liver by an albumin-Cre transgene occurs progressively with age","volume":"26","author":"C Postic","year":"2000","journal-title":"Genesis"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"P Soriano","year":"1999","journal-title":"Nat Genet"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/gut.2008.171116","article-title":"Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?","volume":"58","author":"P Sancho-Bru","year":"2009","journal-title":"Gut"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00534-012-0544-4","article-title":"Characteristics of hepatic stem\/progenitor cells in the fetal and adult liver","volume":"19","author":"H Koike","year":"2012","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"ref22","article-title":"Hepatotoxicology","author":"RG Meeks","year":"1991"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1053\/j.gastro.2009.12.055","article-title":"Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress","volume":"138","author":"S Hanada","year":"2010","journal-title":"Gastroenterology"},{"issue":"36","key":"ref24","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.3748\/wjg.v16.i36.4526","article-title":"Liver disease and erythropoietic protoporphyria: a concise review","volume":"16","author":"MJ Casanova-Gonzalez","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1172-4-19","article-title":"Erythropoietic protoporphyria","volume":"4","author":"M Lecha","year":"2009","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.2353\/ajpath.2010.100173","article-title":"Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine","volume":"177","author":"MD Thompson","year":"2010","journal-title":"Am J Pathol"},{"issue":"7436","key":"ref27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"M Huch","year":"2013","journal-title":"Nature"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/hep.27217","article-title":"Retinoblastoma protein potentiates the innate immune response in hepatocytes: significance for hepatocellular carcinoma","volume":"60","author":"J Hutcheson","year":"2014","journal-title":"Hepatology"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tcb.2013.06.002","article-title":"Physiological significance of polyploidization in mammalian cells","volume":"23","author":"SK Pandit","year":"2013","journal-title":"Trends Cell Biol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI73957","article-title":"Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease","volume":"125","author":"G Gentric","year":"2015","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1038\/ncomms7790","article-title":"Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing","volume":"6","author":"RR White","year":"2015","journal-title":"Nat Commun"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1091\/mbc.E10-11-0895","article-title":"RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo","volume":"22","author":"RJ Bourgo","year":"2011","journal-title":"Mol Biol Cell"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1158\/0008-5472.CAN-04-4221","article-title":"Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy","volume":"65","author":"CN Mayhew","year":"2005","journal-title":"Cancer Res"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/hep.26233","article-title":"P53 Regulates a Mitotic Transcription Program and Determines Ploidy in Normal Mouse Liver","volume":"57","author":"S Kurinna","year":"2013","journal-title":"Hepatology"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"M Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/path.2086","article-title":"P53: at the Crossroad between Cancer and Ageing","volume":"211","author":"C Papazoglu","year":"2007","journal-title":"J Pathol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1535-6108(02)00102-2","article-title":"The RB and p53 pathways in cancer","volume":"2","author":"CJ Sherr","year":"2002","journal-title":"Cancer Cell"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1053\/j.gastro.2011.06.046","article-title":"RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage","volume":"141","author":"AK McClendon","year":"2011","journal-title":"Gastroenterology"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.ajpath.2014.02.025","article-title":"RB tumor suppressive function in response to xenobiotic hepatocarcinogens","volume":"184","author":"C Reed","year":"2014","journal-title":"Am J Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T23:38:35Z","timestamp":1718408315000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150064"}},"subtitle":[],"editor":[{"given":"Matias A","family":"Avila","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150064","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]}}}