{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:06:08Z","timestamp":1790352368547,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150642","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T13:56:22Z","timestamp":1456926982000},"page":"e0150642","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Comparable Efficacy of Tigecycline versus Colistin Therapy for Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Pneumonia in Critically Ill Patients"],"prefix":"10.1371","volume":"11","author":[{"given":"Won-Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Young","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Won","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae-Man","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younsuck","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bum","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"<italic>Acinetobacter baumannii<\/italic>: emergence of a successful pathogen","volume":"21","author":"AY Peleg","year":"2008","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1186\/cc4869","article-title":"Attributable mortality of <italic>Acinetobacter baumannii<\/italic> infections in critically ill patients: a systematic review of matched cohort and case-control studies","volume":"10","author":"ME Falagas","year":"2006","journal-title":"Crit Care"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/AAC.01464-06","article-title":"Global challenge of multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"51","author":"F Perez","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1086\/429323","article-title":"Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections","volume":"40","author":"ME Falagas","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/AAC.00103-06","article-title":"Heteroresistance to colistin in multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"50","author":"J Li","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/AAC.00766-07","article-title":"Colistin heteroresistance in acinetobacter and its association with previous colistin therapy","volume":"52","author":"JS Hawley","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/cid\/cir611","article-title":"Incidence of and risk factors for colistin-associated nephrotoxicity in a large academic health system","volume":"53","author":"JM Pogue","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"Suppl 5","key":"ref8","doi-asserted-by":"crossref","first-page":"S341","DOI":"10.1086\/431675","article-title":"The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam","volume":"41","author":"EJ Ellis-Grosse","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2334-5-88","article-title":"A multicenter trial of the efficacy and safety of tigecycline versus imipenem\/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744]","volume":"5","author":"ME Oliva","year":"2005","journal-title":"BMC Infect Dis"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jac\/dkn165","article-title":"Tigecycline for the treatment of multidrug-resistant (including carbapenem-resistant) Acinetobacter infections: a review of the scientific evidence","volume":"62","author":"DE Karageorgopoulos","year":"2008","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jac\/dkp301","article-title":"Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungs","volume":"64","author":"JL Crandon","year":"2009","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1592\/phco.27.7.980","article-title":"Early experience with tigecycline for ventilator-associated pneumonia and bacteremia caused by multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"27","author":"JJ Schafer","year":"2007","journal-title":"Pharmacotherapy"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1086\/526775","article-title":"Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline","volume":"46","author":"KB Anthony","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"AP Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"JL Vincent","year":"1996","journal-title":"Intensive Care Med"},{"issue":"5 Pt 1","key":"ref16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1121","article-title":"Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic &quot;blind&quot; bronchoalveolar lavage fluid","volume":"143","author":"J Pugin","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.diagmicrobio.2013.08.011","article-title":"Risk factors for hospital-acquired pneumonia caused by carbapenem-resistant Gram-negative bacteria in critically ill patients: a multicenter study in Korea","volume":"78","author":"T Kim","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1086\/657242","article-title":"Aerosolized plus intravenous colistin versus intravenous colistin alone for the treatment of ventilator-associated pneumonia: a matched case-control study","volume":"51","author":"DP Kofteridis","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jinf.2008.04.002","article-title":"Efficacy and safety of high-dose ampicillin\/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant <italic>Acinetobacter baumannii<\/italic> ventilator-associated pneumonia","volume":"56","author":"AP Betrosian","year":"2008","journal-title":"J Infect"},{"key":"ref20","article-title":"Performance standards for antimicrobial susceptibility testing; 22nd informational supplement. (M100-S22)","year":"2012"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2334-14-102","article-title":"Effectiveness of tigecycline-based versus colistin- based therapy for treatment of pneumonia caused by multidrug-resistant <italic>Acinetobacter baumannii<\/italic> in a critical setting: a matched cohort analysis","volume":"14","author":"YC Chuang","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/CCM.0000000000000933","article-title":"Excess Mortality Associated With Colistin-Tigecycline Compared With Colistin-Carbapenem Combination Therapy for Extensively Drug-Resistant <italic>Acinetobacter baumannii<\/italic> Bacteremia: A Multicenter Prospective Observational Study","volume":"43","author":"A Cheng","year":"2015","journal-title":"Crit Care Med"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ajic.2011.12.014","article-title":"Retrospective evaluation of colistin versus tigecycline for the treatment of <italic>Acinetobacter baumannii<\/italic> and\/or carbapenem-resistant Enterobacteriaceae infections","volume":"40","author":"K Ku","year":"2012","journal-title":"Am J Infect Control"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10096-013-1870-4","article-title":"Clinical outcomes of tigecycline alone or in combination with other antimicrobial agents for the treatment of patients with healthcare-associated multidrug-resistant <italic>Acinetobacter baumannii<\/italic> infections","volume":"32","author":"YT Lee","year":"2013","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/jac\/dku233","article-title":"Monotherapy versus combination therapy for sepsis due to multidrug-resistant <italic>Acinetobacter baumannii<\/italic>: analysis of a multicentre prospective cohort","volume":"69","author":"LE Lopez-Cortes","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1128\/JCM.02424-06","article-title":"Surveillance cultures and duration of carriage of multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"45","author":"D Marchaim","year":"2007","journal-title":"J Clin Microbiol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijantimicag.2009.01.015","article-title":"Tigecycline possibly underdosed for the treatment of pneumonia: a pharmacokinetic viewpoint","volume":"34","author":"O Burkhardt","year":"2009","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.diagmicrobio.2010.05.012","article-title":"Comparison of tigecycline with imipenem\/cilastatin for the treatment of hospital-acquired pneumonia","volume":"68","author":"AT Freire","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1128\/AAC.01232-12","article-title":"Randomized phase 2 trial to evaluate the clinical efficacy of two high-dosage tigecycline regimens versus imipenem-cilastatin for treatment of hospital-acquired pneumonia","volume":"57","author":"J Ramirez","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10096-014-2070-6","article-title":"Comparison of colistin-carbapenem, colistin-sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant <italic>Acinetobacter baumannii<\/italic> bloodstream infections","volume":"33","author":"A Batirel","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"e52349","DOI":"10.1371\/journal.pone.0052349","article-title":"Epidemiology, clinical characteristics and outcomes of extensively drug-resistant <italic>Acinetobacter baumannii<\/italic> infections among solid organ transplant recipients","volume":"7","author":"RK Shields","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/AAC.49.1.220-229.2005","article-title":"Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects","volume":"49","author":"G Muralidharan","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/00365548.2012.732705","article-title":"Tigecycline in carbapenem-resistant <italic>Acinetobacter baumannii<\/italic> bacteraemia: susceptibility and clinical outcome","volume":"45","author":"NH Kim","year":"2013","journal-title":"Scand J Infect Dis"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/jac\/dkl441","article-title":"<italic>Acinetobacter baumannii<\/italic> bloodstream infection while receiving tigecycline: a cautionary report","volume":"59","author":"AY Peleg","year":"2007","journal-title":"J Antimicrob Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:36:01Z","timestamp":1540334161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150642"}},"subtitle":[],"editor":[{"given":"Yung-Fu","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150642","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}