{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:51:46Z","timestamp":1790304706558,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150767","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T18:53:39Z","timestamp":1457636019000},"page":"e0150767","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis"],"prefix":"10.1371","volume":"11","author":[{"given":"Hanneke","family":"Borgdorff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne L. P.","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles F.","family":"Ndayisaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Wastling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke H. H. M.","family":"van de Wijgert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e105998","DOI":"10.1371\/journal.pone.0105998","article-title":"The vaginal microbiota: what have we learned after a decade of molecular characterization?","volume":"9","author":"JH van de Wijgert","year":"2014","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1000416","DOI":"10.1371\/journal.pmed.1000416","article-title":"Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis","volume":"8","author":"N Low","year":"2011","journal-title":"PLoS Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"RL Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/JCM.29.2.297-301.1991","article-title":"Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation","volume":"29","author":"RP Nugent","year":"1991","journal-title":"J. Clin. Microbiol"},{"key":"ref5","first-page":"14","article-title":"Nonspecific vaginitis\u2014diagnostic criteria and microbial and epidemiologic associations","volume":"74","author":"R Amsel","year":"1983","journal-title":"Am. J. Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12879-015-1027-4","article-title":"Making inroads into improving treatment of bacterial vaginosis\u2014striving for long-term cure","volume":"15","author":"CS Bradshaw","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/ismej.2014.26","article-title":"Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV\/STI prevalence and genital HIV viral load in African women","volume":"8","author":"H Borgdorff","year":"2014","journal-title":"ISME J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12879-015-0831-1","article-title":"Correlates of the molecular vaginal microbiota composition of African women","volume":"15","author":"R Gautam","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2049-2618-1-12","article-title":"Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis","volume":"1","author":"JM Macklaim","year":"2013","journal-title":"Microbiome"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/OLQ.0b013e31820b8eba","article-title":"High human immunodeficiency virus incidence in a cohort of Rwandan female sex workers","volume":"38","author":"SL Braunstein","year":"2011","journal-title":"Sex Transm Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/OLQ.0000000000000245","article-title":"The impact of hormonal contraception and pregnancy on sexually transmitted infections and on cervicovaginal microbiota in african sex workers","volume":"42","author":"H Borgdorff","year":"2015","journal-title":"Sex Transm Dis"},{"key":"ref12","article-title":"Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier","author":"H Borgdorff","year":"2015","journal-title":"Mucosal Immunol"},{"key":"ref13","first-page":"80","article-title":"Partially Supervised Learning. Second IAPR International Workshop, Nanjing, China, May 2013","author":"E Tsivtsivadze","year":"2013"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e0130404","DOI":"10.1371\/journal.pone.0130404","article-title":"Non-cationic proteins are associated with HIV neutralizing activity in genital secretions of female sex workers","volume":"10","author":"KD Birse","year":"2015","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1021\/pr200596r","article-title":"Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers","volume":"10","author":"A Burgener","year":"2011","journal-title":"J Proteome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-5956-7-17","article-title":"Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples","volume":"7","author":"G Zegels","year":"2009","journal-title":"Proteome Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"JA Vizca\u00edno","year":"2014","journal-title":"Nat Biotechnol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e49506","DOI":"10.1371\/journal.pone.0049506","article-title":"<italic>Lactobacillus<\/italic> proteins are associated with the bactericidal activity against <italic>E<\/italic>. <italic>coli<\/italic> of female genital tract secretions","volume":"7","author":"S Kalyoussef","year":"2012","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1099\/mic.0.2006\/000901-0","article-title":"Extracellular proteins of <italic>Lactobacillus crispatus<\/italic> enhance activation of human plasminogen","volume":"153","author":"V Hurmalainen","year":"2007","journal-title":"Microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/JB.00378-07","article-title":"pH dependent association of enolase and glyceraldehyde-3-phosphate dehydrogenase of <italic>Lactobacillus crispatus<\/italic> with the cell wall and lipoteichoic acids","volume":"189","author":"J Antikainen","year":"2007","journal-title":"J. Bacteriol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/JB.06704-11","article-title":"Glutamine synthetase and glucose-6-phosphate isomerase are adhesive moonlighting proteins of <italic>Lactobacillus crispatus<\/italic> released by epithelial cathelicidin LL-37","volume":"194","author":"V Kainulainen","year":"2012","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbapap.2007.11.007","article-title":"Proteomic investigation of the aggregation phenomenon in <italic>Lactobacillus crispatus<\/italic>","volume":"1784","author":"RA Siciliano","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 1","key":"ref23","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1073\/pnas.1000086107","article-title":"At the crossroads of vaginal health and disease, the genome sequence of <italic>Lactobacillus iners<\/italic> AB-1","volume":"108","author":"JM Macklaim","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1042\/BST20140236","article-title":"An overview of protein moonlighting in bacterial infection","volume":"42","author":"B Henderson","year":"2014","journal-title":"Biochem Soc Trans"},{"key":"ref25","first-page":"178","article-title":"Dancing to another tune-adhesive moonlighting proteins in bacteria","volume":"3","author":"V Kainulainen","year":"2014","journal-title":"Biology (Basel)"},{"key":"ref26","first-page":"15","article-title":"The roles of moonlighting proteins in bacteria","volume":"16","author":"G Wang","year":"2014","journal-title":"Curr Issues Mol Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.micres.2013.01.003","article-title":"Anchorless surface associated glycolytic enzymes from <italic>Lactobacillus plantarum<\/italic> 299v bind to epithelial cells and extracellular matrix proteins","volume":"168","author":"J Glenting","year":"2013","journal-title":"Microbiol Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1365-2672.2007.03679.x","article-title":"Cell surface Lactobacillus plantarum LA 318 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) adheres to human colonic mucin","volume":"104","author":"H Kinoshita","year":"2008","journal-title":"J Appl Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1042\/BST20140203","article-title":"Fructose-1,6-bisphosphate aldolase (FBA)-a conserved glycolytic enzyme with virulence functions in bacteria: &apos;ill met by moonlight&apos;","volume":"42","author":"F Shams","year":"2014","journal-title":"Biochem Soc Trans"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.resmic.2008.06.002","article-title":"Surface-bound proteins of <italic>Lactobacillus plantarum<\/italic> 423 that contribute to adhesion of Caco-2 cells and their role in competitive exclusion and displacement of <italic>Clostridium sporogenes<\/italic> and <italic>Enterococcus faecalis<\/italic>","volume":"159","author":"K Ramiah","year":"2008","journal-title":"Res Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4049\/jimmunol.178.3.1379","article-title":"<italic>Streptococcus agalactiae<\/italic> GAPDH is a virulence-associated immunomodulatory protein","volume":"178","author":"P Madureira","year":"2007","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/10408410490435151","article-title":"The physiological role of ferritin-like compounds in bacteria","volume":"30","author":"JL Smith","year":"2004","journal-title":"Crit Rev Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1099\/mic.0.082156-0","article-title":"Comparison of genes required for H2O2 resistance in <italic>Streptococcus gordonii<\/italic> and <italic>Streptococcus sanguinis<\/italic>","volume":"160","author":"Y Xu","year":"2014","journal-title":"Microbiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/AEM.72.1.956-959.2006","article-title":"Emergence of biofilm-forming subpopulations upon exposure of <italic>Escherichia coli<\/italic> to environmental bacteriophages","volume":"72","author":"A Lacqua","year":"2006","journal-title":"Appl Environ Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:05:13Z","timestamp":1600301113000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150767"}},"subtitle":[],"editor":[{"given":"David N","family":"Fredricks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150767","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}