{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:09:49Z","timestamp":1771603789397,"version":"3.50.1"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150850","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T17:49:02Z","timestamp":1458236942000},"page":"e0150850","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I"],"prefix":"10.1371","volume":"11","author":[{"given":"Omar","family":"Khalid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moin U.","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"Gordts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Matthew","family":"Ellinwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia I.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Esko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"ref1","article-title":"The Online Metabolic and Molecular Bases of Inherited Diseases","author":"EF Neufeld","year":"2013"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.carpath.2014.01.001","article-title":"Unexpected coronary artery findings in mucopolysaccharidosis. Report of four cases and literature review","volume":"23","author":"E Braunlin","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"ref3","first-page":"649","article-title":"Coronary artery disease in the Hurler syndrome. Qualitative and quantitative analysis of the extent of coronary narrowing at necropsy in six children","volume":"47","author":"FC Brosius","year":"1981","journal-title":"Am J Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.1975.03240210031015","article-title":"Myocardial infarction without atherosclerosis","volume":"231","author":"MD Cheitlin","year":"1975","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S104795110999062X","article-title":"Echocardiographic study of paediatric patients with mucopolysaccharidosis","volume":"20","author":"GN Leal","year":"2010","journal-title":"Cardiol Young"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0002-9149(76)90468-9","article-title":"The heart in the Hurler syndrome: gross, histologic and ultrastructural observations in five necropsy cases","volume":"38","author":"VG Renteria","year":"1976","journal-title":"Am J Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1182\/blood-2014-11-608075","article-title":"Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study","volume":"125","author":"M Aldenhoven","year":"2015","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ymgme.2006.08.007","article-title":"A follow-up study of MPS I patients treated with laronidase enzyme replacement therapy for 6 years","volume":"90","author":"M Sifuentes","year":"2007","journal-title":"Mol Genet Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10545-006-0239-6","article-title":"Limitations of enzyme replacement therapy: current and future","volume":"29","author":"JE Wraith","year":"2006","journal-title":"J Inherit Metab Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jpeds.2004.01.046","article-title":"Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase)","volume":"144","author":"JE Wraith","year":"2004","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.amjcard.2006.02.047","article-title":"Cardiac findings after enzyme replacement therapy for mucopolysaccharidosis type I","volume":"98","author":"EA Braunlin","year":"2006","journal-title":"Am J Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1017\/S1047951109003576","article-title":"The natural course and the impact of therapies of cardiac involvement in the mucopolysaccharidoses","volume":"19","author":"V Fesslova","year":"2009","journal-title":"Cardiol Young"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s10545-005-0211-x","article-title":"Mucopolysaccharidosis I under enzyme replacement therapy with laronidase\u2014a mortality case with autopsy report","volume":"28","author":"HY Lin","year":"2005","journal-title":"J Inherit Metab Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1007\/s10545-009-1057-4","article-title":"Postmortem studies on a patient with mucopolysaccharidosis type I: histopathological findings after one year of enzyme replacement therapy","volume":"32","author":"S Yano","year":"2009","journal-title":"J Inherit Metab Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10545-011-9438-x","article-title":"Endothelial function in children and adolescents with mucopolysaccharidosis","volume":"36","author":"AS Kelly","year":"2013","journal-title":"J Inherit Metab Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00380-007-1013-x","article-title":"The mild form of mucopolysaccharidosis type I (Scheie syndrome) is associated with increased ascending aortic stiffness","volume":"23","author":"A Nemes","year":"2008","journal-title":"Heart Vessels"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ymgme.2013.11.001","article-title":"Carotid intima-media thickness is increased in patients with treated mucopolysaccharidosis types I and II, and correlates with arterial stiffness","volume":"111","author":"RY Wang","year":"2014","journal-title":"Mol Genet Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ymgme.2011.09.004","article-title":"Carotid intima-media thickness is increased in patients with mucopolysaccharidoses","volume":"104","author":"RY Wang","year":"2011","journal-title":"Mol Genet Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ymgme.2014.12.284","article-title":"Carotid intima-media thickness and arterial stiffness of pediatric mucopolysaccharidosis patients are increased compared to both pediatric and adult populations","volume":"114","author":"RY Wang","year":"2015","journal-title":"Mol Genet Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.2460\/ajvr.1990.51.12.2054","article-title":"Cardiovascular changes after bone marrow transplantation in dogs with mucopolysaccharidosis I","volume":"51","author":"RE Gompf","year":"1990","journal-title":"Am J Vet Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/bmme.1996.0044","article-title":"Long-term and high-dose trials of enzyme replacement therapy in the canine model of mucopolysaccharidosis I","volume":"58","author":"ED Kakkis","year":"1996","journal-title":"Biochem Mol Med"},{"key":"ref22","first-page":"487","article-title":"Morphologic and biochemical studies of canine mucopolysaccharidosis I","volume":"114","author":"RM Shull","year":"1984","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/labinvest.2011.7","article-title":"Arterial pathology in canine mucopolysaccharidosis-I and response to therapy","volume":"91","author":"JA Lyons","year":"2011","journal-title":"Lab Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1203\/01.pdr.0000190579.24054.39","article-title":"Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in hurler syndrome","volume":"59","author":"E Braunlin","year":"2006","journal-title":"Pediatr Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymgme.2005.05.003","article-title":"Cardiac manifestations in the mouse model of mucopolysaccharidosis I","volume":"86","author":"MC Jordan","year":"2005","journal-title":"Mol Genet Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/jnr.21912","article-title":"Innate and adaptive immune activation in the brain of MPS IIIB mouse model","volume":"87","author":"J DiRosario","year":"2009","journal-title":"J Neurosci Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1742-2094-7-39","article-title":"Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response","volume":"7","author":"S Killedar","year":"2010","journal-title":"J Neuroinflammation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/brain\/awu355","article-title":"Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model","volume":"138","author":"C Martins","year":"2015","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e32419","DOI":"10.1371\/journal.pone.0032419","article-title":"Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology","volume":"7","author":"MK Parente","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/jnr.21134","article-title":"Cytokines, neurotrophins, and oxidative stress in brain disease from mucopolysaccharidosis IIIB","volume":"85","author":"GR Villani","year":"2007","journal-title":"J Neurosci Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ymgme.2011.08.018","article-title":"Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation","volume":"104","author":"G Baldo","year":"2011","journal-title":"Mol Genet Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ymthe.2004.08.027","article-title":"Liver-directed neonatal gene therapy prevents cardiac, bone, ear, and eye disease in mucopolysaccharidosis I mice","volume":"11","author":"Y Liu","year":"2005","journal-title":"Mol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e2296","DOI":"10.1371\/journal.pone.0002296","article-title":"Early neurodegeneration progresses independently of microglial activation by heparan sulfate in the brain of mucopolysaccharidosis IIIB mice","volume":"3","author":"J Ausseil","year":"2008","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ymgme.2009.12.003","article-title":"Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression","volume":"99","author":"JA Metcalf","year":"2010","journal-title":"Mol Genet Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0888-7543(05)80182-X","article-title":"Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I","volume":"14","author":"KP Menon","year":"1992","journal-title":"Genomics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ymgme.2014.05.015","article-title":"Intra-articular enzyme replacement therapy with rhIDUA is safe, well-tolerated, and reduces articular GAG storage in the canine model of mucopolysaccharidosis type I","volume":"112","author":"RY Wang","year":"2014","journal-title":"Mol Genet Metab"},{"key":"ref37","first-page":"293","article-title":"Quantification of atherosclerosis in mice","volume":"209","author":"A Daugherty","year":"2003","journal-title":"Methods Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gdata.2014.06.011","article-title":"Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs)","volume":"2","author":"O Khalid","year":"2014","journal-title":"Genom Data"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.scr.2014.03.009","article-title":"Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells","volume":"12","author":"O Khalid","year":"2014","journal-title":"Stem Cell Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/stem.1675","article-title":"Discovery of consensus gene signature and intermodular connectivity defining self-renewal of human embryonic stem cells","volume":"32","author":"JJ Kim","year":"2014","journal-title":"Stem Cells"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"41103","DOI":"10.1074\/jbc.M112.416545","article-title":"A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells","volume":"287","author":"JJ Kim","year":"2012","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1311s27","article-title":"Extracting biological meaning from large gene lists with DAVID","author":"W Huang da","year":"2009","journal-title":"Curr Protoc Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"D Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"P Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/bj20031048","article-title":"Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII","volume":"379","author":"JC Woloszynek","year":"2004","journal-title":"Biochem J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1016\/S0021-9258(18)42760-3","article-title":"Expression of porcine complement cytolysis inhibitor mRNA in cultured aortic smooth muscle cells. Changes during differentiation in vitro","volume":"267","author":"V Diemer","year":"1992","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0022-2275(20)41208-8","article-title":"Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis","volume":"35","author":"TC Jordan-Starck","year":"1994","journal-title":"J Lipid Res"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004804","article-title":"Lysosomal lipid storage diseases","volume":"3","author":"H Schulze","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/hmg\/ddm289","article-title":"A block of autophagy in lysosomal storage disorders","volume":"17","author":"C Settembre","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jmb.2014.09.012","article-title":"Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology","volume":"427","author":"J Bruyere","year":"2015","journal-title":"J Mol Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1073\/pnas.252784899","article-title":"Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB","volume":"100","author":"K Ohmi","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation","volume":"97","author":"R Wada","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"YC Lu","year":"2008","journal-title":"Cytokine"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.4049\/jimmunol.168.10.5233","article-title":"Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4","volume":"168","author":"GB Johnson","year":"2002","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10545-013-9613-3","article-title":"Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity","volume":"37","author":"LD Archer","year":"2014","journal-title":"J Inherit Metab Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1073\/pnas.0912937107","article-title":"Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses","volume":"107","author":"CM Simonaro","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10545-013-9649-4","article-title":"Mucopolysaccharidosis VI: cardiac involvement and the impact of enzyme replacement therapy","volume":"37","author":"C Kampmann","year":"2014","journal-title":"J Inherit Metab Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.20316","article-title":"Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation","volume":"11","author":"K Moreth","year":"2012","journal-title":"Cell Cycle"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1172\/JCI23755","article-title":"The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages","volume":"115","author":"L Schaefer","year":"2005","journal-title":"J Clin Invest"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00432778","article-title":"Coronary intimal sclerosis in Morquio's syndrome","volume":"379","author":"SM Factor","year":"1978","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ymgme.2013.04.009","article-title":"Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder","volume":"109","author":"E Yasuda","year":"2013","journal-title":"Mol Genet Metab"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.ATV.18.4.665","article-title":"Distribution and synthesis of apolipoprotein J in the atherosclerotic aorta","volume":"18","author":"Y Ishikawa","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0021-9150(01)00416-6","article-title":"Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: findings from the PDAY study","volume":"158","author":"Y Ishikawa","year":"2001","journal-title":"Atherosclerosis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5551\/jat.5819","article-title":"Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-alpha","volume":"18","author":"N Hamada","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/ATVBAHA.109.190058","article-title":"Protective role of clusterin\/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells","volume":"29","author":"HJ Kim","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1160\/TH07-12-0737","article-title":"Potential protective role of apoprotein J (clusterin) in atherogenesis: binding to enzymatically modified low-density lipoprotein reduces fatty acid-mediated cytotoxicity","volume":"100","author":"M Schwarz","year":"2008","journal-title":"Thromb Haemost"},{"key":"ref69","first-page":"537","article-title":"Apolipoprotein J and leptin levels in patients with coronary heart disease","volume":"22","author":"MV Poulakou","year":"2008","journal-title":"In Vivo"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0531-5565(02)00139-0","article-title":"Serum levels of the senescence biomarker clusterin\/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction","volume":"37","author":"IP Trougakos","year":"2002","journal-title":"Exp Gerontol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"KJ Moore","year":"2011","journal-title":"Cell"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.ATV.7.4.333","article-title":"Glycosaminoglycans and apolipoproteins B and A-I in human aortas. Chemical and immunological analysis of lesion-free aortas from children and adults","volume":"7","author":"S Yla-Herttuala","year":"1987","journal-title":"Arteriosclerosis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/j.ymgme.2014.12.080","article-title":"Intranasal enzyme replacement therapy in mice","volume":"114","author":"JD Esko","year":"2015","journal-title":"Mol Genet Metab"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e100882","DOI":"10.1371\/journal.pone.0100882","article-title":"Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment","volume":"9","author":"M Frohbergh","year":"2014","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e54459","DOI":"10.1371\/journal.pone.0054459","article-title":"Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses","volume":"8","author":"EH Schuchman","year":"2013","journal-title":"PLoS One"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.ymgme.2014.12.241","article-title":"Pentosan polysufate: New mechanistic insights and treatment of the mucopolysaccharidosis","volume":"114","author":"CM Simonaro","year":"2015","journal-title":"Mor Genet Metab"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:27:50Z","timestamp":1718418470000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150850"}},"subtitle":[],"editor":[{"given":"Lachlan J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150850","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}