{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:17:54Z","timestamp":1772497074994,"version":"3.50.1"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150904","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T18:34:01Z","timestamp":1457721241000},"page":"e0150904","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)\/ Myalgic Encephalomyelitis (ME)"],"prefix":"10.1371","volume":"11","author":[{"given":"Robert D.","family":"Petty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil E.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifca","family":"Le Dieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"ref1","unstructured":"group Tcmosw. A report of the CFS\/ME Working Group. 2002."},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000075315","article-title":"Neuroendocrine aspects of chronic fatigue syndrome","volume":"11","author":"DA Papanicolaou","year":"2004","journal-title":"Neuroimmunomodulation"},{"issue":"12","key":"ref3","first-page":"953","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study","volume":"121","author":"K Fukuda","year":"1994","journal-title":"International Chronic Fatigue Syndrome Study Group. Ann Intern Med"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/014107689108400224","article-title":"A report\u2014chronic fatigue syndrome: guidelines for research","volume":"84","author":"MC Sharpe","year":"1991","journal-title":"J R Soc Med"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1300\/J092v11n01_02","article-title":"Myalgic Encephalomyelitis\/ Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols","volume":"11","author":"BM Carruthers","year":"2003","journal-title":"Journal of Chronic Fatigue Syndrome"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"e16872","DOI":"10.1371\/journal.pone.0016872","article-title":"Assessment of a 44 gene classifier for the evaluation of chronic fatigue syndrome from peripheral blood mononuclear cell gene expression","volume":"6","author":"D Frampton","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/jcp.2005.025718","article-title":"Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome","volume":"58","author":"N Kaushik","year":"2005","journal-title":"J Clin Pathol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1155\/2002\/892374","article-title":"Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndrome","volume":"18","author":"SD Vernon","year":"2002","journal-title":"Dis Markers"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1744-9081-6-76","article-title":"Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome","volume":"6","author":"MA Fletcher","year":"2010","journal-title":"Behav Brain Funct"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn3087","article-title":"Chronic fatigue syndrome: understanding a complex illness","volume":"12","author":"ST Holgate","year":"2011","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1128\/JCM.28.6.1403-1410.1990","article-title":"Immunologic abnormalities in chronic fatigue syndrome","volume":"28","author":"NG Klimas","year":"1990","journal-title":"J Clin Microbiol"},{"key":"ref12","article-title":"Role of adaptive and innate immune cells in chronic fatigue syndrome\/myalgic encephalomyelitis","author":"EW Brenu","year":"2014","journal-title":"Int Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1479-5876-9-81","article-title":"Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis","volume":"9","author":"EW Brenu","year":"2011","journal-title":"J Transl Med"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2249.2005.02935.x","article-title":"Chronic fatigue syndrome is associated with diminished intracellular perforin","volume":"142","author":"KJ Maher","year":"2005","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-1-10","article-title":"Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome","volume":"1","author":"T Whistler","year":"2003","journal-title":"J Transl Med"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2217\/14622416.7.3.395","article-title":"Gene expression correlates of unexplained fatigue","volume":"7","author":"T Whistler","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6793-5-5","article-title":"Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects","volume":"5","author":"T Whistler","year":"2005","journal-title":"BMC Physiol"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1046\/j.1365-2222.2003.01745.x","article-title":"Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients","volume":"33","author":"R Powell","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2217\/14622416.7.3.407","article-title":"Identifying illness parameters in fatiguing syndromes using classical projection methods","volume":"7","author":"G Broderick","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2217\/14622416.7.3.375","article-title":"Gene expression profile of empirically delineated classes of unexplained chronic fatigue","volume":"7","author":"L Carmel","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2217\/14622416.7.3.429","article-title":"Gene expression profile exploration of a large dataset on chronic fatigue syndrome","volume":"7","author":"H Fang","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2217\/14622416.7.3.441","article-title":"Exploration of the gene expression correlates of chronic unexplained fatigue using factor analysis","volume":"7","author":"J Fostel","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2796.2005.01548.x","article-title":"Gene expression profiling in the chronic fatigue syndrome","volume":"258","author":"H Grans","year":"2005","journal-title":"J Intern Med"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1086\/533453","article-title":"Gene expression subtypes in patients with chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"197","author":"JR Kerr","year":"2008","journal-title":"J Infect Dis"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/jcp.2007.053553","article-title":"Seven genomic subtypes of chronic fatigue syndrome\/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes","volume":"61","author":"JR Kerr","year":"2008","journal-title":"J Clin Pathol"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s11926-008-0079-5","article-title":"Gene profiling of patients with chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"10","author":"JR Kerr","year":"2008","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2007.03.008","article-title":"miR-181a is an intrinsic modulator of T cell sensitivity and selection","volume":"129","author":"QJ Li","year":"2007","journal-title":"Cell"},{"issue":"5654","key":"ref28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1091903","article-title":"MicroRNAs modulate hematopoietic lineage differentiation","volume":"303","author":"CZ Chen","year":"2004","journal-title":"Science"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"S Roush","year":"2008","journal-title":"Trends Cell Biol"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.cell.2010.05.017","article-title":"A MicroRNA targeting dicer for metastasis control","volume":"141","author":"G Martello","year":"2010","journal-title":"Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1479-5876-7-96","article-title":"Plasma cytokines in women with chronic fatigue syndrome","volume":"7","author":"MA Fletcher","year":"2009","journal-title":"J Transl Med"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1182\/blood-2005-03-1140","article-title":"A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity","volume":"107","author":"JL Meade","year":"2006","journal-title":"Blood"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000322720","article-title":"The CD6 scavenger receptor is differentially expressed on a CD56 natural killer cell subpopulation and contributes to natural killer-derived cytokine and chemokine secretion","volume":"3","author":"M Braun","year":"2011","journal-title":"J Innate Immun"},{"issue":"17","key":"ref34","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1182\/blood-2011-09-379693","article-title":"Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor","volume":"119","author":"E Montaldo","year":"2012","journal-title":"Blood"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbamcr.2012.03.003","article-title":"Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death","volume":"1823","author":"MM Kaminski","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.freeradbiomed.2010.11.025","article-title":"Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge","volume":"50","author":"AJ Case","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1093\/ndt\/gfq673","article-title":"Expression of neutrophil SOD2 is reduced after lipopolysaccharide stimulation: a potential cause of neutrophil dysfunction in chronic kidney disease","volume":"26","author":"J Olsson","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"17","key":"ref38","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.1128\/JVI.02666-08","article-title":"Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection","volume":"83","author":"Q Liu","year":"2009","journal-title":"J Virol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.immuni.2006.12.007","article-title":"Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration","volume":"26","author":"B Wu","year":"2007","journal-title":"Immunity"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/jcp.2006.042754","article-title":"Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works","volume":"60","author":"BM Carruthers","year":"2007","journal-title":"J Clin Pathol"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"e102783","DOI":"10.1371\/journal.pone.0102783","article-title":"High-throughput sequencing of plasma microRNA in chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"9","author":"EW Brenu","year":"2014","journal-title":"PLoS One"},{"issue":"2\u20133","key":"ref42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jad.2012.03.037","article-title":"Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis","volume":"141","author":"EW Brenu","year":"2012","journal-title":"J Affect Disord"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4161\/rna.21083","article-title":"Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma","volume":"9","author":"A Turchinovich","year":"2012","journal-title":"RNA Biol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"H Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"e5540","DOI":"10.1371\/journal.pone.0005540","article-title":"Intra-platform repeatability and inter-platform comparability of microRNA microarray technology","volume":"4","author":"F Sato","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1046-2023(03)00161-0","article-title":"Focused microarray analysis","volume":"31","author":"E Wurmbach","year":"2003","journal-title":"Methods"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2144\/04364ST02","article-title":"Comparison of mRNA gene expression by RT-PCR and DNA microarray","volume":"36","author":"W Etienne","year":"2004","journal-title":"Biotechniques"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1525-1578(10)60646-0","article-title":"Validation of array-based gene expression profiles by real-time (kinetic) RT-PCR","volume":"3","author":"MS Rajeevan","year":"2001","journal-title":"J Mol Diagn"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/gb-2009-10-6-r64","article-title":"A novel and universal method for microRNA RT-qPCR data normalization","volume":"10","author":"P Mestdagh","year":"2009","journal-title":"Genome Biol"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"e10817","DOI":"10.1371\/journal.pone.0010817","article-title":"Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV\/CD26","volume":"5","author":"MA Fletcher","year":"2010","journal-title":"PLoS One"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00109-004-0586-4","article-title":"Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndrome","volume":"82","author":"M Steinau","year":"2004","journal-title":"J Mol Med (Berl)"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jpain.2009.06.003","article-title":"Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects","volume":"10","author":"AR Light","year":"2009","journal-title":"J Pain"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"e78762","DOI":"10.1371\/journal.pone.0078762","article-title":"Profile of cerebrospinal microRNAs in fibromyalgia","volume":"8","author":"JL Bjersing","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"e0121903","DOI":"10.1371\/journal.pone.0121903","article-title":"Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia","volume":"10","author":"G Cerda-Olmedo","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"e0121975","DOI":"10.1371\/journal.pone.0121975","article-title":"Identification of Differential MicroRNAs in Cerebrospinal Fluid and Serum of Patients with Major Depressive Disorder","volume":"10","author":"Y Wan","year":"2015","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpsychires.2014.08.007","article-title":"Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients","volume":"59","author":"HM Fan","year":"2014","journal-title":"J Psychiatr Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1479-5876-10-88","article-title":"Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"10","author":"EW Brenu","year":"2012","journal-title":"J Transl Med"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.leukres.2005.09.001","article-title":"Hematopoietic-specific microRNA expression in human cells","volume":"30","author":"SH Ramkissoon","year":"2006","journal-title":"Leuk Res"},{"issue":"5740","key":"ref59","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA","volume":"309","author":"CL Jopling","year":"2005","journal-title":"Science"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.canlet.2010.06.004","article-title":"miR-126 functions as a tumour suppressor in human gastric cancer","volume":"298","author":"R Feng","year":"2010","journal-title":"Cancer Lett"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ni.2767","article-title":"The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids","volume":"15","author":"J Agudo","year":"2014","journal-title":"Nat Immunol"},{"issue":"8","key":"ref62","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1093\/nar\/gkq1003","article-title":"Expression of CD44 3&apos;-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis","volume":"39","author":"Z Jeyapalan","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"38","key":"ref63","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/onc.2009.192","article-title":"MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation","volume":"28","author":"KH Lee","year":"2009","journal-title":"Oncogene"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/abbs\/gmq038","article-title":"MicroRNAs and prostate cancer","volume":"42","author":"Y Pang","year":"2010","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2\u20133","key":"ref65","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.diff.2010.06.005","article-title":"MicroRNAs determine human intestinal epithelial cell fate","volume":"80","author":"G Dalmasso","year":"2010","journal-title":"Differentiation"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ijc.25715","article-title":"Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response","volume":"129","author":"A Gougelet","year":"2011","journal-title":"Int J Cancer"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/gcc.20837","article-title":"Identification of altered MicroRNA expression patterns in synovial sarcoma","volume":"50","author":"M Hisaoka","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"issue":"25","key":"ref68","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1182\/blood-2009-08-237495","article-title":"Identification of microRNA expression patterns and definition of a microRNA\/mRNA regulatory network in distinct molecular groups of multiple myeloma","volume":"114","author":"M Lionetti","year":"2009","journal-title":"Blood"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1210\/me.2008-0387","article-title":"MicroRNA-regulated pathways associated with endometriosis","volume":"23","author":"EM Ohlsson Teague","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/CEJ.0b013e328305a07a","article-title":"Expression profile of mammalian microRNAs in endometrioid adenocarcinoma","volume":"18","author":"W Wu","year":"2009","journal-title":"Eur J Cancer Prev"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"e64434","DOI":"10.1371\/journal.pone.0064434","article-title":"MicroRNA-99 family targets AKT\/mTOR signaling pathway in dermal wound healing","volume":"8","author":"Y Jin","year":"2013","journal-title":"PLoS One"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fimmu.2014.00187","article-title":"The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions","volume":"5","author":"N Nandagopal","year":"2014","journal-title":"Front Immunol"},{"issue":"10","key":"ref73","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/eji.200737281","article-title":"Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli","volume":"37","author":"AC Donahue","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1744-9081-4-44","article-title":"Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood","volume":"4","author":"AL Aspler","year":"2008","journal-title":"Behav Brain Funct"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3892\/or.2013.2452","article-title":"microRNA-330 inhibits cell motility by downregulating Sp1 in prostate cancer cells","volume":"30","author":"Y Mao","year":"2013","journal-title":"Oncol Rep"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.bbrc.2013.01.016","article-title":"miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42","volume":"431","author":"Y Li","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"K Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/intimm\/dxt068","article-title":"Role of adaptive and innate immune cells in chronic fatigue syndrome\/myalgic encephalomyelitis","volume":"26","author":"EW Brenu","year":"2014","journal-title":"Int Immunol"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/jcp.2006.042754","article-title":"Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works","volume":"60","author":"BM Carruthers","year":"2007","journal-title":"Journal of Clinical Pathology"},{"issue":"5","key":"ref80","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1017\/S1461145711000940","article-title":"Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression","volume":"15","author":"PA Melas","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"issue":"5","key":"ref81","first-page":"1527","article-title":"Direct effects of pure nicotine, cigarette smoke extract, Swedish-type smokeless tobacco (Snus) extract and ethanol on human normal endothelial cells and fibroblasts","volume":"31","author":"N Laytragoon-Lewin","year":"2011","journal-title":"Anticancer Res"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1472-6963-3-25","article-title":"Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution","volume":"3","author":"WC Reeves","year":"2003","journal-title":"BMC Health Serv Res"},{"issue":"9","key":"ref83","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1261\/rna.2610405","article-title":"An optimized isolation and labeling platform for accurate microRNA expression profiling","volume":"11","author":"J Shingara","year":"2005","journal-title":"RNA"},{"issue":"10","key":"ref84","doi-asserted-by":"crossref","first-page":"e7440","DOI":"10.1371\/journal.pone.0007440","article-title":"Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls","volume":"4","author":"A Keller","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"ref85","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biol"},{"issue":"15","key":"ref86","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"CL Andersen","year":"2004","journal-title":"Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:34:30Z","timestamp":1655253270000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150904"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":86,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150904","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]}}}