{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:29:47Z","timestamp":1779233387427,"version":"3.51.4"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150941","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T18:48:16Z","timestamp":1457549296000},"page":"e0150941","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hierarchy Low CD4+\/CD8+ T-Cell Counts and IFN-\u03b3 Responses in HIV-1+ Individuals Correlate with Active TB and\/or M.tb Co-Infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Lingyun","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunya","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng W.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1005136","article-title":"New Regimens to Prevent Tuberculosis in Adults with HIV Infection","volume":"365","author":"NA Martinson","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/CMR.00042-10","article-title":"HIV and Tuberculosis: a Deadly Human Syndemic","volume":"24","author":"CK Kwan","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nri1704","article-title":"Tuberculosis control in the era of HIV","volume":"5","author":"P Nunn","year":"2005","journal-title":"Nat Rev Immuno"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1164\/rccm.200306-837OC","article-title":"Mycobacterium tuberculosis\u2014specific CD8+T Cells Preferentially Recognize Heavily Infected Cells","volume":"168","author":"DA Lewinsohn","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/IAI.70.2.869-877.2002","article-title":"Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection","volume":"70","author":"Y Shen","year":"2002","journal-title":"Infect Immun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.1301373","article-title":"CD4+ T Cells Contain Early Extrapulmonary Tuberculosis (TB) Dissemination and Rapid TB Progression and Sustain Multieffector Functions of CD8+ T and CD3- Lymphocytes: Mechanisms of CD4+ T Cell Immunity","volume":"192","author":"S Yao","year":"2014","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1000392","DOI":"10.1371\/journal.ppat.1000392","article-title":"A critical role for CD8 T cells in a nonhuman primate model of tuberculosis","volume":"5","author":"CY Chen","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1097\/QAD.0b013e3283320dfd","article-title":"Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention?","volume":"23","author":"AD Grant","year":"2009","journal-title":"AIDS"},{"key":"ref9","unstructured":"Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents.2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adult_oi.pdf\" xlink:type=\"simple\">http:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adult_oi.pdf<\/ext-link>"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/cid\/cir900","article-title":"Impaired CD4 T-Cell Count Response to Combined Antiretroviral Therapy in Antiretroviral-Naive HIV-Infected Patients Presenting With Tuberculosis as AIDS-Defining Condition","volume":"54","author":"A Cingolani","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/cid\/cis203","article-title":"Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries","volume":"54","author":"TH-C Collaboration","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1097\/QAD.0b013e3283117f18","article-title":"Potent immune responses of Ag-specific V\u03b32V\u03b42+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans","volume":"22","author":"L Shao","year":"2008","journal-title":"AIDS"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2172-10-31","article-title":"High-sensitive and rapid detection of Mycobacterium tuberculosis infection by IFN-gamma release assay among HIV-infected individuals in BCG-vaccinated area","volume":"10","author":"W Jiang","year":"2009","journal-title":"BMC Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1128\/CVI.00294-10","article-title":"Evaluation of Gamma Interferon Release Assays Using Mycobacterium tuberculosis Antigens for Diagnosis of Latent and Active Tuberculosis in Mycobacterium bovis BCG-Vaccinated Populations","volume":"17","author":"S Zhang","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/IAI.01126-10","article-title":"HIV-1\/Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?","volume":"79","author":"CR Diedrich","year":"2011","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/QAD.0b013e328353bcaf","article-title":"CD8(+) T cells in preventing HIV infection and disease","volume":"26","author":"AB McDermott","year":"2012","journal-title":"AIDS"},{"key":"ref17","first-page":"268","article-title":"Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis","volume":"7","author":"C Geldmacher","year":"2012","journal-title":"Curr Opin HIV AIDS"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1164\/rccm.200907-1011OC","article-title":"HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria","volume":"180","author":"B Kalsdorf","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/thx.2010.153825","article-title":"Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults","volume":"66","author":"KC Jambo","year":"2011","journal-title":"Thorax"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20100090","article-title":"Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection","volume":"207","author":"C Geldmacher","year":"2010","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/infdis\/jir421","article-title":"Risk Factors for Tuberculosis After Highly Active Antiretroviral Therapy Initiation in the United States and Canada: Implications for Tuberculosis Screening","volume":"204","author":"TR Sterling","year":"2011","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"14023","DOI":"10.1128\/JVI.78.24.14023-14032.2004","article-title":"Clinical Latency and Reactivation of AIDS-Related Mycobacterial Infections","volume":"78","author":"Y Shen","year":"2004","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.4049\/jimmunol.1000399","article-title":"Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment","volume":"184","author":"JS Sutherland","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI38482","article-title":"Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans","volume":"119","author":"H Bruns","year":"2009","journal-title":"J Clin Invest"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T13:57:11Z","timestamp":1540216631000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150941"}},"subtitle":[],"editor":[{"given":"Srikanth Prasad","family":"Tripathy","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150941","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}