{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:50:33Z","timestamp":1770155433516,"version":"3.49.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0150988","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T18:48:38Z","timestamp":1457030918000},"page":"e0150988","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Missed, Not Missing: Phylogenomic Evidence for the Existence of Avian FoxP3"],"prefix":"10.1371","volume":"11","author":[{"given":"Michael P.","family":"Denyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dammy Y.","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver A.","family":"Garden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"issue":"6012","key":"ref1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.1195568","article-title":"Has the microbiota played a critical role in the evolution of the adaptive immune system?","volume":"330","author":"YK Lee","year":"2010","journal-title":"Science"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2012.05.031","article-title":"Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict","volume":"150","author":"RM Samstein","year":"2012","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-61737-979-6_1","article-title":"Regulatory T cells: history and perspective","volume":"707","author":"S Sakaguchi","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.14.2.142","article-title":"Unified nomenclature for the winged helix\/forkhead transcription factors","volume":"14","author":"KH Kaestner","year":"2000","journal-title":"Genes Dev"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrg2523","article-title":"The evolution of Fox genes and their role in development and disease","volume":"10","author":"S Hannenhalli","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.4049\/jimmunol.177.5.3133","article-title":"Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor","volume":"177","author":"JE Lopes","year":"2006","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fimmu.2012.00113","article-title":"Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution","volume":"3","author":"KG Andersen","year":"2012","journal-title":"Front Immunol"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/intimm\/dxh165","article-title":"Crucial role of FOXP3 in the development and function of human CD25<sup>+<\/sup>CD4<sup>+<\/sup> regulatory T cells","volume":"16","author":"H Yagi","year":"2004","journal-title":"Int Immunol"},{"issue":"5609","key":"ref9","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"S Hori","year":"2003","journal-title":"Science"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2567.2010.03346.x","article-title":"Phenotypic and functional characterization of a CD4<sup>+<\/sup>CD25<sup>high<\/sup>FOXP3<sup>high<\/sup> regulatory T-cell population in the dog","volume":"132","author":"D Pinheiro","year":"2011","journal-title":"Immunology"},{"issue":"1\u20132","key":"ref11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vetimm.2007.11.007","article-title":"Cloning of feline FOXP3 and detection of expression in CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cells","volume":"122","author":"S Lankford","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"issue":"1\u20132","key":"ref12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.vetimm.2008.05.007","article-title":"Detection of Foxp3 protein expression in porcine T lymphocytes","volume":"125","author":"T Kaser","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"issue":"1\u20132","key":"ref13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vetimm.2010.07.009","article-title":"Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry","volume":"138","author":"W Gerner","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"issue":"1\u20132","key":"ref14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.vetimm.2011.07.010","article-title":"Identification of CD4<sup>+<\/sup>CD25<sup>high<\/sup>Foxp3<sup>+<\/sup> T cells in ovine peripheral blood","volume":"144","author":"MS Rocchi","year":"2011","journal-title":"Vet Immunol Immunopathol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.transproceed.2008.10.079","article-title":"Rapamycin promotes the enrichment of CD4<sup>+<\/sup>CD25<sup>hi<\/sup>FoxP3<sup>+<\/sup> T regulatory cells from naive CD4<sup>+<\/sup> T cells of baboon that suppress antiporcine xenogenic response <italic>in vitro<\/italic>","volume":"41","author":"AK Singh","year":"2009","journal-title":"Transplant Proc"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1742-4658.2009.07460.x","article-title":"Identification and characterization of the transcription factors involved in T-cell development, <italic>t-bet<\/italic>, <italic>stat6<\/italic> and <italic>foxp3<\/italic>, within the zebrafish, <italic>Danio rerio<\/italic>","volume":"277","author":"S Mitra","year":"2010","journal-title":"FEBS J"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.dci.2014.07.015","article-title":"T cell transcripts and T cell activities in the gills of the teleost fish sea bass (<italic>Dicentrarchus labrax<\/italic>)","volume":"47","author":"N Nunez Ortiz","year":"2014","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"e9478","DOI":"10.1371\/journal.pone.0009478","article-title":"Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish","volume":"5","author":"FJ Quintana","year":"2010","journal-title":"PLoS One"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.molimm.2010.06.015","article-title":"Identification of two FoxP3 genes in rainbow trout (<italic>Oncorhynchus mykiss<\/italic>) with differential induction patterns","volume":"47","author":"T Wang","year":"2010","journal-title":"Mol Immunol"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetimm.2013.06.004","article-title":"Molecular cloning and expression analysis of <italic>Foxp3<\/italic> from Nile tilapia","volume":"155","author":"J Wei","year":"2013","journal-title":"Vet Immunol Immunopathol"},{"issue":"15","key":"ref21","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s00018-010-0574-5","article-title":"Identification of Treg-like cells in <italic>Tetraodon<\/italic>: insight into the origin of regulatory T subsets during early vertebrate evolution","volume":"68","author":"Y Wen","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.dci.2012.04.010","article-title":"Characterization of Foxp3 gene from grass carp (<italic>Ctenopharyngodon idellus<\/italic>): a rapamycin-inducible transcription factor in teleost immune system","volume":"38","author":"M Yang","year":"2012","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.fsi.2011.01.012","article-title":"Molecular cloning and characterization of Foxp3 in Atlantic salmon (<italic>Salmo salar<\/italic>)","volume":"30","author":"Z Zhang","year":"2011","journal-title":"Fish Shellfish Immunol"},{"issue":"14","key":"ref24","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1242\/dev.033985","article-title":"Suppression of the immune response potentiates tadpole tail regeneration during the refractory period","volume":"136","author":"T Fukazawa","year":"2009","journal-title":"Development"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.dci.2013.04.018","article-title":"Avian CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cells: properties and therapeutic applications","volume":"41","author":"RK Selvaraj","year":"2013","journal-title":"Dev Comp Immunol"},{"issue":"5","key":"ref26","first-page":"129","article-title":"Regulatory T cells in avian species","volume":"1","author":"RK Selvaraj","year":"2013","journal-title":"Adv Anim Vet Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/ncomms3071","article-title":"Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau","volume":"4","author":"Y Qu","year":"2013","journal-title":"Nat Commun"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2013-14-3-r29","article-title":"Genome sequence of ground tit <italic>Pseudopodoces humilis<\/italic> and its adaptation to high altitude","volume":"14","author":"Q Cai","year":"2013","journal-title":"Genome Biol"},{"key":"ref29","article-title":"Ensembl 2015","author":"F Cunningham","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"ref30","doi-asserted-by":"crossref","first-page":"D61","DOI":"10.1093\/nar\/gkl842","article-title":"NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins","volume":"35","author":"KD Pruitt","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Z Zhang","year":"2000","journal-title":"J Comput Biol"},{"issue":"6215","key":"ref32","doi-asserted-by":"crossref","first-page":"1254449","DOI":"10.1126\/science.1254449","article-title":"Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs","volume":"346","author":"RE Green","year":"2014","journal-title":"Science"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/gb-2012-13-1-415","article-title":"Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes","volume":"13","author":"JA St John","year":"2012","journal-title":"Genome Biol"},{"issue":"17","key":"ref34","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ng0893-332","article-title":"dbEST\u2014database for &quot;expressed sequence tags&quot;","volume":"4","author":"MS Boguski","year":"1993","journal-title":"Nat Genet"},{"issue":"1\u20132","key":"ref36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.vetimm.2010.04.017","article-title":"<italic>In vitro<\/italic> human TGF-beta treatment converts CD4<sup>+<\/sup>CD25<sup>-<\/sup> T cells into induced T regulatory like cells","volume":"137","author":"R Shanmugasundaram","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1101\/gr.1865504","article-title":"GeneWise and Genomewise","volume":"14","author":"E Birney","year":"2004","journal-title":"Genome Res"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2\u2014a multiple sequence alignment editor and analysis workbench","volume":"25","author":"AM Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"e110808","DOI":"10.1371\/journal.pone.0110808","article-title":"Diverse and widespread contamination evident in the unmapped depths of high throughput sequencing data","volume":"9","author":"RW Lusk","year":"2014","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"ref41","doi-asserted-by":"crossref","first-page":"S10.1","DOI":"10.1186\/gb-2006-7-s1-s10","article-title":"Automatic annotation of eukaryotic genes, pseudogenes and promoters","volume":"7","author":"V Solovyev","year":"2006","journal-title":"Genome Biol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/molbev\/msq182","article-title":"Alternative splicing and gene duplication in the evolution of the FoxP gene subfamily","volume":"28","author":"ME Santos","year":"2011","journal-title":"Mol Biol Evol"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"R112","DOI":"10.1186\/gb-2011-12-11-r112","article-title":"Evaluation of genomic high-throughput sequencing data generated on Illumina HiSeq and genome analyzer systems","volume":"12","author":"AE Minoche","year":"2011","journal-title":"Genome Biol"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"e1003998","DOI":"10.1371\/journal.pcbi.1003998","article-title":"Extensive error in the number of genes inferred from draft genome assemblies","volume":"10","author":"JF Denton","year":"2014","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrg3117","article-title":"Repetitive DNA and next-generation sequencing: computational challenges and solutions","volume":"13","author":"TJ Treangen","year":"2012","journal-title":"Nat Rev Genet"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nmeth.1527","article-title":"Limitations of next-generation genome sequence assembly","volume":"8","author":"C Alkan","year":"2011","journal-title":"Nat Methods"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","article-title":"Easyfig: a genome comparison visualizer","volume":"27","author":"MJ Sullivan","year":"2011","journal-title":"Bioinformatics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13059-015-0724-z","article-title":"Hidden genes in birds","volume":"16","author":"T Hron","year":"2015","journal-title":"Genome Biol"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"e94270","DOI":"10.1371\/journal.pone.0094270","article-title":"Improved annotation of 3&apos; untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-Seq and ESTs","volume":"9","author":"NJ Schurch","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1093\/nar\/gkn290","article-title":"Predicting failure rate of PCR in large genomes","volume":"36","author":"R Andreson","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"ref51","doi-asserted-by":"crossref","first-page":"D19","DOI":"10.1093\/nar\/gkq1019","article-title":"The sequence read archive","volume":"39","author":"R Leinonen","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/intimm\/dxm043","article-title":"FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD\/IPEX autoimmune disease","volume":"19","author":"B Li","year":"2007","journal-title":"Int Immunol"},{"issue":"15\u201316","key":"ref53","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.molimm.2011.05.023","article-title":"Domain requirements for the diverse immune regulatory functions of foxp3","volume":"48","author":"WP Zeng","year":"2011","journal-title":"Mol Immunol"},{"issue":"1\u20132","key":"ref54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vetimm.2012.05.019","article-title":"Regulatory T cell properties of thymic CD4<sup>+<\/sup>CD25<sup>+<\/sup> cells in ducks","volume":"149","author":"R Shanmugasundaram","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.4049\/jimmunol.1002040","article-title":"Regulatory T cell properties of chicken CD4<sup>+<\/sup>CD25<sup>+<\/sup> cells","volume":"186","author":"R Shanmugasundaram","year":"2011","journal-title":"J Immunol"},{"issue":"16","key":"ref56","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.1128\/JVI.00556-12","article-title":"Marek&apos;s disease viral interleukin-8 promotes lymphoma formation through targeted recruitment of B cells and CD4<sup>+<\/sup>CD25<sup>+<\/sup> T cells","volume":"86","author":"AT Engel","year":"2012","journal-title":"J Virol"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3390\/v7031357","article-title":"Changes of CD4<sup>+<\/sup>CD25<sup>+<\/sup> cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences","volume":"7","author":"X Yu","year":"2015","journal-title":"Viruses"},{"issue":"8","key":"ref58","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2527\/jas.2011-4652","article-title":"<italic>In vivo<\/italic> lipopolysaccharide injection alters CD4<sup>+<\/sup>CD25<sup>+<\/sup> cell properties in chickens","volume":"90","author":"R Shanmugasundaram","year":"2012","journal-title":"J Anim Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fimmu.2014.00046","article-title":"Regulatory T cells as immunotherapy","volume":"5","author":"BD Singer","year":"2014","journal-title":"Front Immunol"},{"issue":"21","key":"ref60","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1182\/blood-2012-08-452037","article-title":"Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells","volume":"121","author":"L Pasquet","year":"2013","journal-title":"Blood"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrd3683","article-title":"Therapeutic opportunities for manipulating T<sub>Reg<\/sub> cells in autoimmunity and cancer","volume":"12","author":"H von Boehmer","year":"2013","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tips.2010.12.004","article-title":"FOXP3<sup>+<\/sup> regulatory T cells: control of FOXP3 expression by pharmacological agents","volume":"32","author":"N Ohkura","year":"2011","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00109-014-1156-z","article-title":"Ubiquitous points of control over regulatory T cells","volume":"92","author":"F Pan","year":"2014","journal-title":"J Mol Med (Berl)"},{"key":"ref64","unstructured":"Caspari C. CM, Monti E. Prevention and control of animal diseases worldwide. Part I: Economic analysis\u2014Prevention versus outbreak costs. The World Organisation for Animal Health (OIE). 2007. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.oie.int\/doc\/en_document.php?numrec=3552603\" xlink:type=\"simple\">http:\/\/www.oie.int\/doc\/en_document.php?numrec=3552603<\/ext-link>. Accessed 10 September 2015."},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1477-9552.2005.tb00126.x","article-title":"Updated Estimates of the Costs Associated with Thirty Four Endemic Livestock Diseases in Great Britain: A Note","volume":"56","author":"R Bennett","year":"2005","journal-title":"J Agric Econ"},{"issue":"8","key":"ref66","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0020-7519(99)00086-7","article-title":"A compartmentalised model for the estimation of the cost of coccidiosis to the world&apos;s chicken production industry","volume":"29","author":"RB Williams","year":"1999","journal-title":"Int J Parasitol"},{"issue":"080","key":"ref67","doi-asserted-by":"crossref","DOI":"10.1079\/PAVSNNR20083080","article-title":"Impacts of avian influenza virus on animal production in developing countries","volume":"3","author":"J Otte","year":"2008","journal-title":"CAB Rev: Perspect Agric Vet Sci Nutr Nat Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0150988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T15:43:07Z","timestamp":1654530187000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0150988"}},"subtitle":[],"editor":[{"given":"Francesco","family":"Pappalardo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0150988","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]}}}