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Primeiros resultados do Censo 2010 \/ Popula\u00e7\u00e3o por domic\u00edlio. [cited 2011 July]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/censo2010\/tabelas_pdf\/total_populacao_pernambuco.pdf\" xlink:type=\"simple\">http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/censo2010\/tabelas_pdf\/total_populacao_pernambuco.pdf<\/ext-link>."},{"key":"ref17","article-title":"Designing Clinical Research","author":"SB Hulley","year":"2001"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1740-8709.2008.00154.x","article-title":"Using programme theory to assess the feasibility of delivering micronutrient Sprinkles through a food-assisted maternal and child health and nutrition programme in rural Haiti","volume":"5","author":"CU Loechl","year":"2009","journal-title":"Matern Child Nutr"},{"key":"ref19","unstructured":"World Health Organization. Expert Committee on Physical Status. 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