{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T13:04:12Z","timestamp":1707570252995},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151203","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T13:46:14Z","timestamp":1458222374000},"page":"e0151203","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Percutaneous Mitral Valve Repair in Mitral Regurgitation Reduces Cell-Free Hemoglobin and Improves Endothelial Function"],"prefix":"10.1371","volume":"11","author":[{"given":"Christos","family":"Rammos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Zeus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kubatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike B.","family":"Hendgen-Cotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Veulemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Hellhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Totzeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Luedike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/0002-9149(92)90710-G","article-title":"Endothelial function in chronic congestive heart failure","volume":"69","author":"H Drexler","year":"1992","journal-title":"Am J Cardiol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1161\/01.ATV.0000166516.52477.81","article-title":"Systemic endothelial dysfunction as an early predictor of adverse outcome in heart failure","volume":"25","author":"T Heitzer","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/0735-1097(92)90271-N","article-title":"Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure","volume":"19","author":"SD Katz","year":"1992","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"ref4","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1161\/CIRCULATIONAHA.106.678276","article-title":"Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study","volume":"115","author":"J Yeboah","year":"2007","journal-title":"Circulation"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease","volume":"101","author":"V Schachinger","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/01.CIR.104.2.191","article-title":"Prognostic significance of endothelial dysfunction in hypertensive patients","volume":"104","author":"F Perticone","year":"2001","journal-title":"Circulation"},{"issue":"13","key":"ref7","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"RP Rother","year":"2005","journal-title":"JAMA"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jacc.2009.07.068","article-title":"Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function","volume":"55","author":"C Meyer","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"CD Reiter","year":"2002","journal-title":"Nat Med"},{"issue":"20","key":"ref10","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/hrt.2011.225789","article-title":"Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","volume":"97","author":"A Rossi","year":"2011","journal-title":"Heart"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cardfail.2003.12.006","article-title":"Mitral regurgitation in patients with advanced systolic heart failure","volume":"10","author":"JB Patel","year":"2004","journal-title":"Journal of cardiac failure"},{"issue":"15","key":"ref12","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"T Feldman","year":"2011","journal-title":"N Engl J Med"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jacc.2009.03.077","article-title":"Percutaneous mitral repair with the MitraClip system: safety and midterm durability in the initial EVEREST (Endovascular Valve Edge-to-Edge REpair Study) cohort","volume":"54","author":"T Feldman","year":"2009","journal-title":"Journal of the American College of Cardiology"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.jacc.2005.07.065","article-title":"Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial","volume":"46","author":"T Feldman","year":"2005","journal-title":"Journal of the American College of Cardiology"},{"issue":"15","key":"ref15","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/CIRCULATIONAHA.112.001039","article-title":"Relationship between the magnitude of reduction in mitral regurgitation severity and left ventricular and left atrial reverse remodeling after MitraClip therapy","volume":"128","author":"PA Grayburn","year":"2013","journal-title":"Circulation"},{"key":"ref16","article-title":"Integrated reverse left and right ventricular remodelling after MitraClip implantation in functional mitral regurgitation: an echocardiographic study","author":"C Giannini","year":"2013","journal-title":"European heart journal cardiovascular Imaging"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2012.05.003","article-title":"Higher endogenous nitrite levels are associated with superior exercise capacity in highly trained athletes","volume":"27","author":"M Totzeck","year":"2012","journal-title":"Nitric oxide: biology and chemistry \/ official journal of the Nitric Oxide Society"},{"issue":"22","key":"ref18","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.jacc.2008.01.059","article-title":"Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial","volume":"51","author":"J Balzer","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"ref19","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2013.08.691","article-title":"Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk","volume":"63","author":"C Rammos","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1016\/j.ijcard.2013.08.021","article-title":"Macrophage migration inhibitory factor is associated with vascular dysfunction in patients with end-stage renal disease","volume":"168","author":"C Rammos","year":"2013","journal-title":"Int J Cardiol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2006.04.006","article-title":"Plasma nitrite reserve and endothelial function in the human forearm circulation","volume":"41","author":"T Rassaf","year":"2006","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.freeradbiomed.2012.02.051","article-title":"Dietary inorganic nitrate mobilizes circulating angiogenic cells","volume":"52","author":"C Heiss","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"14","key":"ref23","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jacc.2009.10.064","article-title":"Vascular formation of nitrite after exercise is abolished in patients with cardiovascular risk factors and coronary artery disease","volume":"55","author":"T Rassaf","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2215\/CJN.05560515","article-title":"Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double-Blind, Randomized, Placebo-Controlled Trial","volume":"11","author":"T Rassaf","year":"2016","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1002\/ccd.25570","article-title":"Safety and efficacy of deep sedation as compared to general anaesthesia in percutaneous mitral valve repair using the MitraClip(R) system","volume":"84","author":"T Rassaf","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/ccd.25705","article-title":"Influence of percutaneous mitral valve repair using the MitraClip(R) system on renal function in patients with severe mitral regurgitation","volume":"85","author":"T Rassaf","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0041-100102","article-title":"Mitral regurgitation: update 2015","volume":"140","author":"C Rammos","year":"2015","journal-title":"Dtsch Med Wochenschr"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"e111178","DOI":"10.1371\/journal.pone.0111178","article-title":"Safety and Efficacy of Percutaneous Mitral Valve Repair Using the MitraClip(R) System in Patients with Diabetes Mellitus","volume":"9","author":"K Hellhammer","year":"2014","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijcard.2015.02.081","article-title":"Percutaneous mitral valve repair using the MitraClip(R) system in patients with anemia","volume":"184C","author":"K Hellhammer","year":"2015","journal-title":"Int J Cardiol"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ehjci\/jet105","article-title":"Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging","volume":"14","author":"P Lancellotti","year":"2013","journal-title":"European heart journal cardiovascular Imaging"},{"issue":"12","key":"ref31","first-page":"1231","article-title":"Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations","volume":"65","author":"AW Asgar","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1939-1676.2011.00846.x","article-title":"Flow-mediated vasodilation measurements in Cavalier King Charles Spaniels with increasing severity of myxomatous mitral valve disease","volume":"26","author":"SG Moesgaard","year":"2012","journal-title":"Journal of veterinary internal medicine \/ American College of Veterinary Internal Medicine"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"E695","DOI":"10.1152\/ajpendo.00016.2013","article-title":"Endothelial microparticles increase in mitral valve disease and impair mitral valve endothelial function","volume":"304","author":"HB Ci","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.freeradbiomed.2003.11.019","article-title":"Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide","volume":"36","author":"RP Patel","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"31","key":"ref35","doi-asserted-by":"crossref","first-page":"11477","DOI":"10.1073\/pnas.0402201101","article-title":"Biological activity of nitric oxide in the plasmatic compartment","volume":"101","author":"X Wang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/eurheartj\/ehi001","article-title":"Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death","volume":"26","author":"D Fischer","year":"2005","journal-title":"Eur Heart J"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI200524459","article-title":"NO\/redox disequilibrium in the failing heart and cardiovascular system","volume":"115","author":"JM Hare","year":"2005","journal-title":"J Clin Invest"},{"issue":"16","key":"ref38","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1161\/01.CIR.99.16.2113","article-title":"Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure","volume":"99","author":"SD Katz","year":"1999","journal-title":"Circulation"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/01.RES.69.4.1088","article-title":"Diminished endothelium-derived relaxing factor activity in an experimental model of chronic heart failure","volume":"69","author":"M Ontkean","year":"1991","journal-title":"Circ Res"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijcard.2004.05.030","article-title":"Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure","volume":"100","author":"D Tousoulis","year":"2005","journal-title":"Int J Cardiol"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/hrt.2005.061333","article-title":"Endothelial function and clinical outcome","volume":"91","author":"JA Vita","year":"2005","journal-title":"Heart"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jacc.2013.04.030","article-title":"4-year results of a randomized controlled trial of percutaneous repair versus surgery for mitral regurgitation","volume":"62","author":"L Mauri","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jacc.2013.02.094","article-title":"Percutaneous mitral valve interventions in the real world: early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe","volume":"62","author":"F Maisano","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/ejcts\/ezs294","article-title":"Mitraclip therapy and surgical mitral repair in patients with moderate to severe left ventricular failure causing functional mitral regurgitation: a single-centre experience","volume":"42","author":"M Taramasso","year":"2012","journal-title":"European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/eurjhf\/hfr029","article-title":"MitraClip(R) therapy in patients with end-stage systolic heart failure","volume":"13","author":"O Franzen","year":"2011","journal-title":"Eur J Heart Fail"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:07:47Z","timestamp":1540339667000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151203"}},"subtitle":[],"editor":[{"given":"Carlos","family":"Zaragoza","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151203","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}