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Q-fever. 2015. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.nvwa.nl\/onderwerpen\/bacterien-ziekteverwekkers\/dossier\/q-koorts\/kaart-met-overzicht-vanbesmette-bedrijven\" xlink:type=\"simple\">https:\/\/www.nvwa.nl\/onderwerpen\/bacterien-ziekteverwekkers\/dossier\/q-koorts\/kaart-met-overzicht-vanbesmette-bedrijven<\/ext-link>. 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Q koorts (Q fever). 2015, April 29th. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.rivm.nl\/Onderwerpen\/Q\/Q_koorts\" xlink:type=\"simple\">http:\/\/www.rivm.nl\/Onderwerpen\/Q\/Q_koorts<\/ext-link>. 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