{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:24:28Z","timestamp":1764174268992},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151431","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T17:37:14Z","timestamp":1457977034000},"page":"e0151431","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1"],"prefix":"10.1371","volume":"11","author":[{"given":"Johannes","family":"van den Boom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Trusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hoppstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Beuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.cdd.4400598","article-title":"Caspase structure, proteolytic substrates, and function during apoptotic cell death","volume":"6","author":"DW Nicholson","year":"1999","journal-title":"Cell Death Differ"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1073\/pnas.73.11.3825","article-title":"Role of proteolytic enzymes in biological regulation (a review)","volume":"73","author":"H Neurath","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","article-title":"Targeting proteases: successes, failures and future prospects","volume":"5","author":"B Turk","year":"2006","journal-title":"Nat Rev Drug Discov"},{"issue":"6555","key":"ref4","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/378416a0","article-title":"A protein catalytic framework with an N-terminal nucleophile is capable of self-activation","volume":"378","author":"JA Brannigan","year":"1995","journal-title":"Nature"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1110\/ps.9.12.2329","article-title":"Structural comparison of Ntn-hydrolases","volume":"9","author":"C Oinonen","year":"2000","journal-title":"Protein Sci"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(03)00816-X","article-title":"Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression","volume":"115","author":"JJ Hsieh","year":"2003","journal-title":"Cell"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1128\/MCB.26.7.2728-2735.2006","article-title":"Uncleaved TFIIA is a substrate for taspase 1 and active in transcription","volume":"26","author":"H Zhou","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"6624","key":"ref8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/386463a0","article-title":"Structure of 20S proteasome from yeast at 2.4 A resolution","volume":"386","author":"M Groll","year":"1997","journal-title":"Nature"},{"issue":"5164","key":"ref9","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.8197456","article-title":"Structure of the allosteric regulatory enzyme of purine biosynthesis","volume":"264","author":"JL Smith","year":"1994","journal-title":"Science"},{"issue":"39","key":"ref10","doi-asserted-by":"crossref","first-page":"25320","DOI":"10.1074\/jbc.273.39.25320","article-title":"Activation and oligomerization of aspartylglucosaminidase","volume":"273","author":"J Saarela","year":"1998","journal-title":"J Biol Chem"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.str.2005.07.006","article-title":"Crystal structure of human Taspase1, a crucial protease regulating the function of MLL","volume":"13","author":"JA Khan","year":"2005","journal-title":"Structure"},{"issue":"34","key":"ref12","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1021\/bi300870g","article-title":"Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis","volume":"51","author":"J Nomme","year":"2012","journal-title":"Biochemistry"},{"issue":"19","key":"ref13","doi-asserted-by":"crossref","first-page":"13388","DOI":"10.1074\/jbc.M800746200","article-title":"The mechanism of autocatalytic activation of plant-type L-asparaginases","volume":"283","author":"K Michalska","year":"2008","journal-title":"J Biol Chem"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/pro.5560070327","article-title":"Crystal structure of glycosylasparaginase from Flavobacterium meningosepticum","volume":"7","author":"J Xuan","year":"1998","journal-title":"Protein Sci"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1600-0854.2011.01191.x","article-title":"The importin-alpha\/nucleophosmin switch controls taspase1 protease function","volume":"12","author":"C Bier","year":"2011","journal-title":"Traffic"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/embo-reports\/kvd092","article-title":"Finding nuclear localization signals","volume":"1","author":"M Cokol","year":"2000","journal-title":"EMBO Rep"},{"issue":"1\u20132","key":"ref17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jim.2004.11.018","article-title":"Asparaginase display of polypeptides in the periplasm of Escherichia coli: potential rapid pepscan technique for antigen epitope mapping","volume":"299","author":"Q Gaofu","year":"2005","journal-title":"J Immunol Methods"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/mrd.10092","article-title":"A novel asparaginase-like protein is a sperm autoantigen in rats","volume":"62","author":"LA Bush","year":"2002","journal-title":"Mol Reprod Dev"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/j.1460-2075.1991.tb07920.x","article-title":"Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease","volume":"10","author":"E Ikonen","year":"1991","journal-title":"EMBO J"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1158\/0008-5472.CAN-11-2584","article-title":"A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth","volume":"72","author":"DY Chen","year":"2012","journal-title":"Cancer Res"},{"issue":"Web Server issue","key":"ref21","doi-asserted-by":"crossref","first-page":"W197","DOI":"10.1093\/nar\/gkn238","article-title":"The Jpred 3 secondary structure prediction server","volume":"36","author":"C Cole","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1021\/bi00699a002","article-title":"Prediction of protein conformation","volume":"13","author":"PY Chou","year":"1974","journal-title":"Biochemistry"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/prot.20251","article-title":"Making optimal use of empirical energy functions: force-field parameterization in crystal space","volume":"57","author":"E Krieger","year":"2004","journal-title":"Proteins"},{"issue":"Suppl 9","key":"ref24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/prot.22570","article-title":"Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8","volume":"77","author":"E Krieger","year":"2009","journal-title":"Proteins"},{"issue":"16","key":"ref25","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/jcc.10349","article-title":"A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations","volume":"24","author":"Y Duan","year":"2003","journal-title":"J Comput Chem"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"e18253","DOI":"10.1371\/journal.pone.0018253","article-title":"Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors","volume":"6","author":"SK Knauer","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"e65346","DOI":"10.1371\/journal.pone.0065346","article-title":"Design of a modular protein-based MRI contrast agent for targeted application","volume":"8","author":"D Grum","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mrc.2225","article-title":"Further conventions for NMR shielding and chemical shifts (IUPAC Recommendations 2008)","volume":"46","author":"RK Harris","year":"2008","journal-title":"Magn Reson Chem"},{"issue":"2\u20133","key":"ref29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(97)01474-9","article-title":"Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins","volume":"419","author":"J Yao","year":"1997","journal-title":"FEBS Lett"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1073\/pnas.89.10.4397","article-title":"Complete 15N and 1H NMR assignments for the amino-terminal domain of the phage 434 repressor in the urea-unfolded form","volume":"89","author":"D Neri","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1472-6807-9-20","article-title":"Relationship between chemical shift value and accessible surface area for all amino acid atoms","volume":"9","author":"WF Vranken","year":"2009","journal-title":"BMC Struct Biol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00227471","article-title":"1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects","volume":"5","author":"DS Wishart","year":"1995","journal-title":"J Biomol NMR"},{"key":"ref33","article-title":"Cleaving for growth: threonine aspartase 1-a protease relevant for development and disease","author":"RH Stauber","year":"2015","journal-title":"FASEB J"},{"key":"ref34","article-title":"Taspase1: a &apos;misunderstood&apos; protease with translational cancer relevance","author":"D Wunsch","year":"2015","journal-title":"Oncogene"},{"issue":"17","key":"ref35","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1101\/gad.1449406","article-title":"Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression","volume":"20","author":"S Takeda","year":"2006","journal-title":"Genes Dev"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/cr.2014.129","article-title":"Taspase1 cleaves MLL1 to activate cyclin E for HER2\/neu breast tumorigenesis","volume":"24","author":"Y Dong","year":"2014","journal-title":"Cell Res"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbrc.2010.02.100","article-title":"Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361\u2013370","volume":"394","author":"Z Hayouka","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.bbamcr.2010.07.010","article-title":"Strategies to inhibit viral protein nuclear import: HIV-1 as a target","volume":"1813","author":"A Levin","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"17","key":"ref39","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.bmcl.2009.07.045","article-title":"Design, syntheses, and evaluation of Taspase1 inhibitors","volume":"19","author":"JT Lee","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"issue":"34","key":"ref40","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1073\/pnas.0404781101","article-title":"Discovery of an allosteric site in the caspases","volume":"101","author":"JA Hardy","year":"2004","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:48:35Z","timestamp":1589046515000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151431"}},"subtitle":[],"editor":[{"given":"Eugene A.","family":"Permyakov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151431","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]}}}