{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:55:27Z","timestamp":1790564127413,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151710","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T19:07:07Z","timestamp":1458328027000},"page":"e0151710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":88,"title":["Weight Loss Predicts Progression of Mild Cognitive Impairment to Alzheimer\u2019s Disease"],"prefix":"10.1371","volume":"11","author":[{"given":"Ilaria","family":"Cova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cucumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ghiretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Maggiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pomati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Caracciolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"RC Petersen","year":"2014","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-0447.2008.01326.x","article-title":"Rate of progression of mild cognitive impairment to dementia\u2014meta-analysis of 41 robust inception cohort studies","volume":"119","author":"AJ Mitchell","year":"2009","journal-title":"Acta Psychiatr Scand"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1176\/appi.ajp.2014.14070878","article-title":"Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis","volume":"172","author":"C Cooper","year":"2015","journal-title":"Am J Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1017\/S0029665112002753","article-title":"Weight loss and Alzheimer\u2019s disease: temporal and aetiologic connections","volume":"72","author":"G Sergi","year":"2013","journal-title":"Proc Nutr Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/ejcn.2014.167","article-title":"Body mass index and mild cognitive impairment-to-dementia progression in 24 months: a prospective study","volume":"68","author":"T Sob\u00f3w","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"ref6","unstructured":"American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual on Mental Disorders. 4th ed. Washington, DC; 1994."},{"key":"ref7","first-page":"189","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"CP Hughes","year":"1982","journal-title":"Br J Psychiatry J Ment Sci"},{"issue":"Suppl 8","key":"ref9","first-page":"1","article-title":"Italian standardization and classification of Neuropsychological tests. The Italian Group on the Neuropsychological Study of Aging","year":"1987","journal-title":"Ital J Neurol Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/01688639708403761","article-title":"Composite neuropsychological batteries and demographic correction: standardization based on equivalent scores, with a review of published data. The Italian Group for the Neuropsychological Study of Ageing","volume":"19","author":"E Capitani","year":"1997","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of Illness in The Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function","volume":"185","author":"S Katz","year":"1963","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"MP Lawton","year":"1969","journal-title":"The Gerontologist"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"JL Cummings","year":"1994","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"JA Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment\u2014beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment","volume":"256","author":"B Winblad","year":"2004","journal-title":"J Intern Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"IG McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"D Neary","year":"1998","journal-title":"Neurology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"GC Rom\u00e1n","year":"1993","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00002093-199903000-00005","article-title":"Informant-based staging of dementia using the clinical dementia rating","volume":"13","author":"L Waite","year":"1999","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/WAD.0000000000000005","article-title":"Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease","volume":"28","author":"LM Besser","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"637S","DOI":"10.1093\/ajcn\/71.2.637s","article-title":"Weight loss in Alzheimer disease","volume":"71","author":"S Gillette-Guyonnet","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcn\/82.2.435","article-title":"Different modes of weight loss in Alzheimer disease: a prospective study of 395 patients","volume":"82","author":"O Gu\u00e9rin","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/j.1532-5415.2008.01935.x","article-title":"A manual of guidelines to score the modified cumulative illness rating scale and its validation in acute hospitalized elderly patients","volume":"56","author":"F Salvi","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000343776","article-title":"Does vascular burden contribute to the progression of mild cognitive impairment to dementia?","volume":"34","author":"F Clerici","year":"2012","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.STR.32.6.1318","article-title":"A new rating scale for age-related white matter changes applicable to MRI and CT","volume":"32","author":"LO Wahlund","year":"2001","journal-title":"Stroke J Cereb Circ"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1532-5415.1996.tb00912.x","article-title":"Weight change in Alzheimer\u2019s disease","volume":"44","author":"H White","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/archneur.63.9.1312","article-title":"Accelerated weight loss may precede diagnosis in Alzheimer disease","volume":"63","author":"DK Johnson","year":"2006","journal-title":"Arch Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/archneur.62.1.55","article-title":"A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study","volume":"62","author":"R Stewart","year":"2005","journal-title":"Arch Neurol"},{"key":"ref30","first-page":"49","article-title":"Progression to dementia in a population with amnestic mild cognitive impairment: clinical variables associated with conversion","volume":"27","author":"M Mauri","year":"2012","journal-title":"Funct Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1017\/S0033291700037491","article-title":"Impaired cognitive functioning during spontaneous dieting","volume":"25","author":"MW Green","year":"1995","journal-title":"Psychol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-4328(01)00364-3","article-title":"The hippocampus and motivation revisited: appetite and activity","volume":"127","author":"AL Tracy","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/jnnp.2010.225003","article-title":"The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population","volume":"82","author":"B Caracciolo","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jamda.2012.12.004","article-title":"Apathy and weight loss in nursing home residents: longitudinal study","volume":"14","author":"L Volicer","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1176\/appi.ajp.157.9.1399","article-title":"Olfactory deficits in patients with mild cognitive impairment predict Alzheimer\u2019s disease at follow-up","volume":"157","author":"DP Devanand","year":"2000","journal-title":"Am J Psychiatry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"MW Schwartz","year":"2000","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm1029","article-title":"Adiponectin acts in the brain to decrease body weight","volume":"10","author":"Y Qi","year":"2004","journal-title":"Nat Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1042\/BST0331029","article-title":"Leptin: a potential cognitive enhancer?","volume":"33","author":"J Harvey","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000051252","article-title":"Circulating leptin levels and weight loss in Alzheimer\u2019s disease patients","volume":"12","author":"DA Power","year":"2001","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref40","first-page":"9821","article-title":"Mechanisms of the anorexia of aging-a review","volume":"37","author":"A Wysoki\u0144ski","year":"2015","journal-title":"Age Dordr Neth"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pnpbp.2004.12.007","article-title":"Mitochondrial aging and dysfunction in Alzheimer\u2019s disease","volume":"29","author":"PG Sullivan","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.02.007","article-title":"Truncated tau and A\u03b2 cooperatively impair mitochondria in primary neurons","volume":"33","author":"RA Quintanilla","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/scientificamerican0897-40","article-title":"Mitochondrial DNA in aging and disease","volume":"277","author":"DC Wallace","year":"1997","journal-title":"Sci Am"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1474-9728.2004.00097.x","article-title":"Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer","volume":"3","author":"JR Speakman","year":"2004","journal-title":"Aging Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2004.10.016","article-title":"Mitochondrial H(+) leak and ROS generation: an odd couple","volume":"38","author":"PS Brookes","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"ref46","first-page":"171","article-title":"Muscle biopsy in Alzheimer\u2019s disease: morphological and biochemical findings","volume":"10","author":"C Mariani","year":"1991","journal-title":"Clin Neuropathol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cca.2011.12.008","article-title":"Integrative role of neuropeptides and cytokines in cancer anorexia-cachexia syndrome","volume":"413","author":"SK Patra","year":"2012","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7440","DOI":"10.1074\/jbc.M109.083915","article-title":"Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss","volume":"285","author":"GW Rebeck","year":"2010","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study","volume":"57","author":"M Visser","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jn\/123.suppl_2.465","article-title":"Sarcopenia and age-related changes in body composition and functional capacity","volume":"123","author":"WJ Evans","year":"1993","journal-title":"J Nutr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T14:43:31Z","timestamp":1567694611000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151710"}},"subtitle":[],"editor":[{"given":"Pradeep","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151710","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}