{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:29Z","timestamp":1791908309701,"version":"4.3.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151765","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T17:45:40Z","timestamp":1458582340000},"page":"e0151765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Impact of a CXCL12\/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Leola N.","family":"Chow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina Y. Y.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Wilder","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vionarica","family":"Gusti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Lecour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Simonson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Manisali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Barta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"McNagny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michael","family":"Underhill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis: mechanisms an treatment strategies","volume":"328","author":"SL Friedman","year":"1993","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"SL Friedman","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/qjmed\/hcs069","article-title":"Liver fibrosis: a bidirectional model of fibrogenesis and resolution","volume":"105","author":"P Ramachandran","year":"2012","journal-title":"QJM: Monthly Journal of the Association of Physicians"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: cellular mechanisms of progression and resolution","volume":"112","author":"NC Henderson","year":"2007","journal-title":"Clinical Science"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s005350070045","article-title":"Hepatic stellate cells: a target for the treatment of liver fibrosis","volume":"35","author":"J Wu","year":"2000","journal-title":"Journal of Gastroenterology"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"JP Iredale","year":"2007","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2006-927387","article-title":"Mouse models of liver fibrosis","volume":"45","author":"C Weiler-Normann","year":"2007","journal-title":"Zeitschriftfur Gastroenterologie"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cld.2008.07.007","article-title":"The global impact of hepatic fibrosis and end-stage liver disease","volume":"12","author":"S Lim Y-","year":"2008","journal-title":"Clinical Liver Disease"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.2000.279.1.G7","article-title":"Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex","volume":"279","author":"FJ Eng","year":"2000","journal-title":"American Journal of Physiology Gastrointestinal & Liver Physiology"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1753-4887.1999.tb01778.x","article-title":"Chronic alcohol intake interferes with retinoid metabolism and signaling","volume":"57","author":"X-D Wang","year":"1999","journal-title":"Nutrition Reviews"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s005350070045","article-title":"Hepatic stellate cells: a target for the treatment of liver fibrosis","volume":"35","author":"J Wu","year":"2000","journal-title":"Journal of Gastroenterology"},{"issue":"9807","key":"ref12","first-page":"1946","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"TE King","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/ajrccm.157.1.9704130","article-title":"Prognostic significance of histopathologic subsets in Idiopathic Pulmonary Fibrosis","volume":"157","author":"JA Bjoraker","year":"1998","journal-title":"American Journal of Respiratory Cell and Critical Care Medicine"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1164\/rccm.200602-163OC","article-title":"Incidence and prevalence of Idiopathic Pulmonary Fibrosis","volume":"174","author":"G Raghu","year":"2006","journal-title":"American Journal of Respiratory Cell and Critical Care Medicine"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S2213-2600(14)70101-8","article-title":"Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001\u201311","volume":"2","author":"G Raghu","year":"2014","journal-title":"The Lancet Respiratory Medicine"},{"issue":"9175","key":"ref16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0140-6736(99)00178-6","article-title":"Pirfenidone in idiopathic pulmonary fibrosis","volume":"354","author":"LP Nicod","year":"1999","journal-title":"The Lancet"},{"issue":"9779","key":"ref17","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/S0140-6736(11)60405-4","article-title":"Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials","volume":"377","author":"PW Noble","year":"2011","journal-title":"The Lancet"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1164\/ajrccm.159.4.9805017","article-title":"Treatment of Idiopathic Pulmonary Fibrosis with a new antifibrotic agent, Pirfenidone","volume":"159","author":"G Raghu","year":"1999","journal-title":"American Journal of Respiratory Cell and Critical Care Medicine"},{"issue":"9193","key":"ref19","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/S0140-6736(99)00347-5","article-title":"New treatments for pulmonary fibrosis?","volume":"354","author":"JJ Egan","year":"1999","journal-title":"The Lancet"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.drudis.2015.01.001","article-title":"Pharmacological treatment of idiopathic pulmonary fibrosis: an update","volume":"20","author":"P Spagnolo","year":"2015","journal-title":"Drug Discovery Today"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1164\/rccm.201212-2297OC","article-title":"Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis","volume":"188","author":"C Hung","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1172\/JCI200418847","article-title":"Bone marrow-derived progenitor cells in pulmonary fibrosis","volume":"113","author":"N Hashimoto","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"issue":"1.2","key":"ref23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2152\/jmi.60.127","article-title":"Antifibrotic effects of CXCR4 antagonist in bleomycin-induced pulmonary fibrosis in mice","volume":"60","author":"H Makino","year":"2013","journal-title":"The Journal of Medical Investigation"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1164\/rccm.200810-1534OC","article-title":"Circulating fibrocytes are an indicator of poor prognosis in Idiopathic Pulmonary Fibrosis","volume":"179","author":"A Moeller","year":"2009","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"RJ Phillips","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3858\/emm.2010.42.6.048","article-title":"Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulomonary fibrosis","volume":"42","author":"JS Song","year":"2010","journal-title":"Experimental and Molecular Medicine"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1165\/rcmb.2006-0187OC","article-title":"Role of the SDF-1\/CXCR4 axis in the pathogenesis of lung injury and fibrosis","volume":"37","author":"J Xu","year":"2007","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.4049\/jimmunol.1400753","article-title":"Fibrocytes are not an essential source of type I collagen during lung fibrosis","volume":"193","author":"KR Kleaveland","year":"2014","journal-title":"J Immunol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/smim.1998.0128","article-title":"A novel CXC chemokine PBSF\/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection","volume":"10","author":"T Nagasawa","year":"1998","journal-title":"Seminars in Immunology"},{"issue":"6685","key":"ref30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/31269","article-title":"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development","volume":"393","author":"Y-R Zou","year":"1998","journal-title":"Nature"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.184.3.1101","article-title":"A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)","volume":"184","author":"CC Bleul","year":"1996","journal-title":"Journal of Experimental Medicine"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.exphem.2006.04.002","article-title":"Mutual, reciprocal SDF-1\/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD\/SCID chimeric mice","volume":"34","author":"A Dar","year":"2006","journal-title":"Experimental Hematology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.2001.tb03577.x","article-title":"Mechanism of human stem cell migration and repopulation of NOS\/SCID and B2mnull NOD\/SCID mice","volume":"938","author":"T Lapidot","year":"2001","journal-title":"Annals fo the New York Academy of Sciences"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1172\/JCI17902","article-title":"HGF, SDF-1 and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver","volume":"112","author":"O Kollet","year":"2003","journal-title":"The Journal of Clinical Investigation"},{"issue":"4","key":"ref35","first-page":"1164","article-title":"Involvement of the CXCR12\/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus European","volume":"34","author":"O Wald","year":"2004","journal-title":"Journal of Immunology"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/hep.22890","article-title":"Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1 \u03b1-mediated stellate cell activation","volume":"49","author":"F Hong","year":"2009","journal-title":"Hepatology"},{"issue":"7481","key":"ref37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12681","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"B-S Ding","year":"2014","journal-title":"Nature"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7150\/thno.5376","article-title":"Small molecule inhibitors of CXCR4","volume":"3","author":"B Debnath","year":"2013","journal-title":"Theranostics"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/AAC.44.6.1667-1673.2000","article-title":"Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers","volume":"44","author":"CW Hendrix","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.4049\/jimmunol.181.9.6670","article-title":"Retraction: Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation","volume":"181","author":"M Watanabe","year":"2008","journal-title":"The Journal of Immunology"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/SLA.0b013e3181f4e479","article-title":"Stem cell mobilization is life saving in an animal model of acute liver failure","volume":"252","author":"AL Mark","year":"2010","journal-title":"Annals of Surgery"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/hepr.12411","article-title":"Inhibition of the CXCL12\/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury","volume":"45","author":"Y Saiman","year":"2015","journal-title":"Hepatology Research"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/op8000993","article-title":"AMD070, a CXCR4 chemokin receptor antagonist: practical large-scale laboratory synthesis","volume":"12","author":"JB Crawford","year":"2008","journal-title":"Organic Process Research & Development"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bcp.2011.11.020","article-title":"The molecular pharmacology of AMD11070: An orally bioavailable CXCR4 HIV entry inhibitor","volume":"83","author":"RM Mosi","year":"2012","journal-title":"Biochemical Pharmacology"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/AAC.00013-07","article-title":"Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects","volume":"51","author":"ND Stone","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1128\/AAC.01460-07","article-title":"Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers","volume":"52","author":"C Ying Jun","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"Pt 16","key":"ref47","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/jcs.084699","article-title":"Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis","volume":"124","author":"HJ Dranse","year":"2011","journal-title":"J Cell Sci"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1021\/jm100073m","article-title":"Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication","volume":"53","author":"RT Skerlj","year":"2010","journal-title":"Journal of Medicinal Chemistry"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1084\/jem.186.8.1383","article-title":"Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4","volume":"186","author":"D Schols","year":"1997","journal-title":"Journal of Experimental Medicine"},{"issue":"7","key":"ref50","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1164\/rccm.200505-717OC","article-title":"Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model","volume":"173","author":"NI Chaudhary","year":"2006","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4049\/jimmunol.175.2.1224","article-title":"Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice","volume":"175","author":"N Hamada","year":"2005","journal-title":"The Journal of Immunology"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA<sub>1<\/sub> links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"AM Tager","year":"2008","journal-title":"Nature Medicine"},{"key":"ref53","unstructured":"Li F, Dai H, Jing G, Xuefeng X, editors. Inhibiting CXCR4\/CXCRL12 axis attenuates lung fibrosis both in vitro and in vivo. European Respiratory Society Annual Congress 2012; 2012; Vienna, Austria."},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"I Mederacke","year":"2013","journal-title":"Nat Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T20:16:39Z","timestamp":1655324199000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151765"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":54,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151765","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}