{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:00:20Z","timestamp":1792515620693,"version":"4.5.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151767","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T13:47:05Z","timestamp":1458222425000},"page":"e0151767","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u03b2-COP as a Component of Transport Vesicles for HDL Apolipoprotein-Mediated Cholesterol Exocytosis"],"prefix":"10.1371","volume":"11","author":[{"given":"Weilie","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0002-9343(77)90874-9","article-title":"High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study","volume":"62","author":"T Gordon","year":"1977","journal-title":"Am J Med"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/hc3501.095214","article-title":"Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study","volume":"104","author":"AR Sharrett","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.CIR.79.1.8","article-title":"High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies","volume":"79","author":"DJ Gordon","year":"1989","journal-title":"Circulation"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1172\/JCI111120","article-title":"Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells","volume":"72","author":"JF Oram","year":"1983","journal-title":"The Journal of clinical investigation"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1210\/endo-123-4-1879","article-title":"High density lipoproteins stimulate placental lactogen release and adenosine 3&apos;,5&apos;-monophosphate (cAMP) production in human trophoblast cells: evidence for cAMP as a second messenger in human placental lactogen release","volume":"123","author":"YQ Wu","year":"1988","journal-title":"Endocrinology"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1074\/jbc.270.11.5891","article-title":"Monensin and brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol-enriched cells. Implications for intracellular cholesterol transport","volume":"270","author":"AJ Mendez","year":"1995","journal-title":"The Journal of biological chemistry"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/S0022-2275(20)37456-3","article-title":"Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus","volume":"37","author":"AJ Mendez","year":"1996","journal-title":"Journal of lipid research"},{"issue":"1\u20133","key":"ref8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.febslet.2004.04.048","article-title":"ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export","volume":"566","author":"T Engel","year":"2004","journal-title":"FEBS letters"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1161\/ATVBAHA.112.300720","article-title":"BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function","volume":"33","author":"S Lin","year":"2013","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.atherosclerosis.2015.02.034","article-title":"Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a\/b levels","volume":"239","author":"W Ma","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0021-9150(99)00503-1","article-title":"Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol","volume":"149","author":"G Lin","year":"2000","journal-title":"Atherosclerosis"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"J Rappsilber","year":"2003","journal-title":"Analytical chemistry"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.011015","article-title":"Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer","volume":"10","author":"A Michalski","year":"2011","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0022-2275(20)33305-8","article-title":"An efficient chromatographic system for lipoprotein fractionation using whole plasma","volume":"39","author":"W Innis-Whitehouse","year":"1998","journal-title":"Journal of lipid research"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1194\/jlr.M400323-JLR200","article-title":"PAT family proteins pervade lipid droplet cores","volume":"46","author":"H Robenek","year":"2005","journal-title":"Journal of lipid research"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s004410051181","article-title":"Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases","volume":"294","author":"HW Heid","year":"1998","journal-title":"Cell and tissue research"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.ATV.0000115638.27381.97","article-title":"Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis","volume":"24","author":"G Larigauderie","year":"2004","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-2275(20)33342-3","article-title":"Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells","volume":"40","author":"JK Bielicki","year":"1999","journal-title":"Journal of lipid research"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1194\/jlr.M500531-JLR200","article-title":"Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I","volume":"47","author":"PT Duong","year":"2006","journal-title":"Journal of lipid research"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0022-2275(20)41505-6","article-title":"Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs","volume":"33","author":"H Herscovitz","year":"1992","journal-title":"Journal of lipid research"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1194\/jlr.R035725","article-title":"Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond","volume":"54","author":"AS Shah","year":"2013","journal-title":"Journal of lipid research"},{"issue":"4746","key":"ref22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"MS Brown","year":"1986","journal-title":"Science"},{"issue":"34","key":"ref23","doi-asserted-by":"crossref","first-page":"25123","DOI":"10.1074\/jbc.M704590200","article-title":"Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles","volume":"282","author":"C Vedhachalam","year":"2007","journal-title":"The Journal of biological chemistry"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2005.05.019","article-title":"Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation","volume":"332","author":"WT Chao","year":"2005","journal-title":"Biochemical and biophysical research communications"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/11914","article-title":"The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease","volume":"22","author":"M Bodzioch","year":"1999","journal-title":"Nature genetics"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/11905","article-title":"Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency","volume":"22","author":"A Brooks-Wilson","year":"1999","journal-title":"Nature genetics"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/11921","article-title":"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1","volume":"22","author":"S Rust","year":"1999","journal-title":"Nature genetics"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/01.ATV.0000054662.44688.9A","article-title":"HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol","volume":"23","author":"JF Oram","year":"2003","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"13","key":"ref29","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.1220703110","article-title":"ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging","volume":"110","author":"KO Nagata","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"48","key":"ref30","doi-asserted-by":"crossref","first-page":"34414","DOI":"10.1074\/jbc.M113.508812","article-title":"Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants","volume":"288","author":"F Quazi","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.biochi.2012.11.009","article-title":"Cholesterol transport via ABCA1: new insights from solid-phase binding assay","volume":"95","author":"E Reboul","year":"2013","journal-title":"Biochimie"},{"issue":"7195","key":"ref32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature06928","article-title":"Functional genomic screen reveals genes involved in lipid-droplet formation and utilization","volume":"453","author":"Y Guo","year":"2008","journal-title":"Nature"},{"issue":"Pt 11","key":"ref33","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1242\/jcs.045849","article-title":"Coatomer-dependent protein delivery to lipid droplets","volume":"122","author":"KG Soni","year":"2009","journal-title":"Journal of cell science"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1247\/csf.11035","article-title":"GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis","volume":"36","author":"K Takashima","year":"2011","journal-title":"Cell structure and function"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/bbrc.2002.6505","article-title":"Insights of high-density lipoprotein apolipoprotein-mediated lipid efflux from cells","volume":"291","author":"G Lin","year":"2002","journal-title":"Biochemical and biophysical research communications"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4161\/cam.21373","article-title":"Actin on trafficking: could actin guide directed receptor transport?","volume":"6","author":"T Zech","year":"2012","journal-title":"Cell adhesion & migration"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1083\/jcb.97.1.40","article-title":"Identification of three coated vesicle components as alpha- and beta-tubulin linked to a phosphorylated 50,000-dalton polypeptide","volume":"97","author":"SR Pfeffer","year":"1983","journal-title":"The Journal of cell biology"},{"key":"ref38","first-page":"530720","article-title":"ApoA-I\/HDL Generation and Intracellular Cholesterol Transport through Cytosolic Lipid-Protein Particles in Astrocytes","volume":"2014","author":"J Ito","year":"2014","journal-title":"Journal of lipids"},{"issue":"29","key":"ref39","doi-asserted-by":"crossref","first-page":"20966","DOI":"10.1074\/jbc.M113.484535","article-title":"Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion","volume":"288","author":"H Zhang","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tibs.2003.08.009","article-title":"More than folding: localized functions of cytosolic chaperones","volume":"28","author":"JC Young","year":"2003","journal-title":"Trends in biochemical sciences"},{"issue":"Pt 5","key":"ref41","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1242\/jcs.015610","article-title":"A novel HSP90 chaperone complex regulates intracellular vesicle transport","volume":"121","author":"GP Lotz","year":"2008","journal-title":"Journal of cell science"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.bbamcr.2010.09.015","article-title":"Annexin A6-Linking Ca(2+) signaling with cholesterol transport","volume":"1813","author":"C Enrich","year":"2011","journal-title":"Biochimica et biophysica acta"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/cvr\/cvs367","article-title":"The lysosomal transfer of LDL\/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration","volume":"97","author":"S Weinert","year":"2013","journal-title":"Cardiovascular research"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0005-2736(81)90512-5","article-title":"Exfoliation of membrane ecto-enzymes in the form of micro-vesicles","volume":"645","author":"EG Trams","year":"1981","journal-title":"Biochimica et biophysica acta"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1083\/jcb.101.3.942","article-title":"Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes","volume":"101","author":"BT Pan","year":"1985","journal-title":"The Journal of cell biology"},{"issue":"2","key":"ref46","first-page":"256","article-title":"Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding","volume":"35","author":"C Harding","year":"1984","journal-title":"European journal of cell biology"},{"issue":"21","key":"ref47","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1002\/pmic.200900351","article-title":"ExoCarta: A compendium of exosomal proteins and RNA","volume":"9","author":"S Mathivanan","year":"2009","journal-title":"Proteomics"},{"issue":"7","key":"ref48","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"AV Vlassov","year":"2012","journal-title":"Biochimica et biophysica acta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T07:21:44Z","timestamp":1655277704000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151767"}},"subtitle":[],"editor":[{"given":"Xuewei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151767","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}