{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:57:59Z","timestamp":1776952679273,"version":"3.51.4"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151851","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T23:02:59Z","timestamp":1458342179000},"page":"e0151851","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Candidate Soluble Immune Mediators in Young Women with High-Risk Human Papillomavirus Infection: High Expression of Chemokines Promoting Angiogenesis and Cell Proliferation"],"prefix":"10.1371","volume":"11","author":[{"given":"Nunzia","family":"Zanotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lina","family":"Tornesello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clorinda","family":"Annunziata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Stellato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco Maria","family":"Buonaguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manola","family":"Comar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e92615","DOI":"10.1371\/journal.pone.0092615","article-title":"Attendance at cervical cancer screening and use of diagnostic and therapeutic procedures on the uterine cervix assessed from individual health insurance data (Belgium, 2002\u20132006)","volume":"9","author":"M Arbyn","year":"2014","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vaccine.2013.10.003","article-title":"Monograph comprehensive control of HPV infections and related diseases","volume":"31","author":"FX Bosch","year":"2013","journal-title":"Vaccine"},{"key":"ref3","first-page":"1","article-title":"Human papillomavirus and cancer: the epidemiology evidence","volume":"19","author":"N Munoz","year":"2000","journal-title":"J ClinVirol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"JM Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vaccine.2008.05.064","article-title":"Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia","volume":"26","author":"FX Bosch","year":"2008","journal-title":"Vaccine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/path.1771","article-title":"E-cadherin-dependent adhesion of dendritic and Langerhans cells to keratinocytes is defective in cervical human papillomavirus-associated (pre) neoplastic lesions","volume":"206","author":"P Hubert","year":"2005","journal-title":"J Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/ijc.27828","article-title":"Patterns of persistent genital human papillomavirus infection among women worldwide: a literature review and meta-analysis","volume":"133","author":"AF Rositch","year":"2013","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/CMR.05028-11","article-title":"Epithelial cell responses to infection with human papillomavirus","volume":"25","author":"MA Stanley","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcancer.2013.11.002","article-title":"The human papillomavirus family and its role in carcinogenesis","volume":"26","author":"M Tommasino","year":"2013","journal-title":"Semin CancerBiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/CS20050369","article-title":"Molecular biology of human papillomavirus infection and cervical cancer","volume":"110","author":"J Doorbar","year":"2006","journal-title":"ClinSci (Lond)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrc700","article-title":"Role of cell cycle biomarkers in human papillomavirus-associated cervical cancer","volume":"2","author":"P Conesa-Zamora","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref12","first-page":"155","article-title":"SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells","volume":"44","author":"M Majka","year":"2006","journal-title":"Folia Histochem Cytobiolol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2353\/ajpath.2009.090295","article-title":"Correlation of CXCL12 Expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer","volume":"175","author":"F Jaafar","year":"2009","journal-title":"Am J Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"C987","DOI":"10.1152\/ajpcell.00406.2006","article-title":"Stroma-derived fector (SDF-1\/CXCL12) and human tumor pathogenesis","volume":"292","author":"I Kryczek","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ijc.24117","article-title":"Diminished IFN-gamma and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3","volume":"12","author":"ME Scott","year":"2009","journal-title":"Int J Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1447-0756.2007.00492.x","article-title":"Immune concept of human papillomavirus and related antigen in local cancer milieu of human cervical neoplasia","volume":"33","author":"BC Sheu","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrc700","article-title":"Immune evasion in human papillomavirus-associated cervical cancer","volume":"2","author":"RW Tindle","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"519619","DOI":"10.1155\/2013\/519619","article-title":"Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer","volume":"2013","author":"ML Tornesello","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref19","first-page":"1021","article-title":"An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV)","volume":"10","author":"PE Castle","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/ijc.28000","article-title":"Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study","volume":"133","author":"SK Hussain","year":"2013","journal-title":"Int J Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/156800907780006869","article-title":"Mechanisms used by human papillomavirus to escape the host immune response","volume":"7","author":"S Kanodia","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/ijc.22894","article-title":"CD4+CD25hi regulatory T-cell frequency correlates with persistence of human papillomvirus type 16 and t helper cell responses in patients with cervical intraepithelial neoplasia","volume":"121","author":"JW Molling","year":"2007","journal-title":"Int J Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ygyno.2013.08.025","article-title":"Immune responses against virus and tumor in cervical carcinogenesis: treatment strategies for avoiding the HPV-induced immune escape","volume":"131","author":"P Conesa-Zamora","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.jid.5700559","article-title":"Human keratinocyte Toll-like receptors promote distinct immune responses","volume":"127","author":"LS Miller","year":"2007","journal-title":"J Invest Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e17848","DOI":"10.1371\/journal.pone.0017848","article-title":"Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes","volume":"6","author":"R Karim","year":"2011","journal-title":"Plos One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2886","article-title":"Human papillomavirus oncoproteins: pathways to transformation","volume":"10","author":"CA Moody","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref27","first-page":"976024","article-title":"Pattern recognition via toll-like receptor system in the female genital tract","author":"K Nasu","year":"2010","journal-title":"Mediators Inflamm"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/JVI.75.9.4283-4296.2001","article-title":"Papillomavirus type 16 oncogenes down-regulate expression of interferon-responsive genes and up-regulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes","volume":"75","author":"M Nees","year":"2001","journal-title":"J Virol"},{"key":"ref29","first-page":"661","article-title":"Human papillomavirus type 16 E7 impairs the activation of the interferon regulatory factor-1","volume":"5","author":"SE Perea","year":"2000","journal-title":"Int J Mol Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1002\/cncr.25224","article-title":"Up regulation of inerleukin-17 expression by human papillomavirus type 16 E6 in non small cell lung cancer","volume":"116","author":"YH Chang","year":"2010","journal-title":"Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.178.5.3186","article-title":"TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type16","volume":"178","author":"UA Hasan","year":"2007","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.20122394","article-title":"The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter","volume":"210","author":"UA Hasan","year":"2013","journal-title":"J Exp Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2005.09.016","article-title":"Human TLR-7,-8, and -9-mediated induction of IFN-alpha\/beta and-lambda Is IRAK-4 dependent and redundant for protective immunity to viruses","volume":"23","author":"K Yang","year":"2005","journal-title":"Immunity"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.humpath.2004.08.012","article-title":"Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions","volume":"35","author":"KK Azar","year":"2004","journal-title":"Human Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.4049\/jimmunol.167.5.2972","article-title":"Predominant Th2\/Th2 polarity of tumor-infiltrating lymphocytes in human cervical","volume":"167","author":"BC Sheu","year":"2001","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","article-title":"The 2001 Bethesda System: terminology for reporting results of cervical cytology","volume":"287","author":"D Solomon","year":"2002","journal-title":"JAMA"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jcv.2013.07.001","article-title":"Human papillomavirus infection is associated with decreased levels of GM-CSF in cervico-vaginal fluid of infected women","volume":"58","author":"M Comar","year":"2013","journal-title":"J Clin Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.vaccine.2005.09.002","article-title":"Immune responses to human papillomavirus","volume":"24","author":"M Stanley","year":"2006","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.5306\/wjco.v5.i4.753","article-title":"Role of IL-10 and TGF-\u03b21 in local immunosuppression in HPV-associated cervical neoplasia","volume":"5","author":"K Torres-Poveda","year":"2014","journal-title":"World J Clin Oncol"},{"key":"ref40","first-page":"540850","article-title":"HPV infection: immunological aspects and their utility in future therapy","author":"E Deligeoroglou","year":"2013","journal-title":"Infect Dis Obstet Gynecol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/vim.2006.19.481","article-title":"In vivo expression of immunosuppressive cytokines in human papillomavirus-transformed cervical cancer cells","volume":"19","author":"JM Alcocer-Gonz\u00e1lez","year":"2006","journal-title":"Viral Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/gyno.2001.6378","article-title":"Cytokine profile of cervical cancer cells","volume":"83","author":"S Hazelbag","year":"2001","journal-title":"Gynecol Oncol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0002-9440(10)65324-2","article-title":"Colonization of in vitro-formed cervical human papillomavirus-associated (pre)neoplastic lesions with dendritic cells: role of granulocyte\/macrophage colony-stimulating factor","volume":"154","author":"P Hubert","year":"1999","journal-title":"Am J Pathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.vaccine.2015.02.019","article-title":"Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation","volume":"33","author":"SJ Lee","year":"2015","journal-title":"Vaccine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e84629","DOI":"10.1371\/journal.pone.0084629","article-title":"Stromal derived factor-1 (SDF-1) and its receptors CXCR4 and CXCR7 in endometrial cancer patients","volume":"9","author":"M Walentowicz-Sadlecka","year":"2014","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/cgt.2011.8","article-title":"Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models","volume":"18","author":"Y Liu","year":"2011","journal-title":"Cancer Gene Ther"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/vim.2013.0097","article-title":"The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV- uninfected women","volume":"27","author":"HD Strickler","year":"2014","journal-title":"Viral Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ejca.2008.02.047","article-title":"Systematic review of the association between circulating interleukin-6 (IL-6) and cancer","volume":"44","author":"K Heikkil\u00e4","year":"2008","journal-title":"Eur J Cancer"},{"key":"ref49","first-page":"24147","article-title":"Cytokine release in HR-HPV(+) women without and with cervical dysplasia (CIN II and III) or carcinoma, compared with HR-HPV(-) controls","volume":"2007","author":"AG Bais","year":"2007","journal-title":"Mediators Inflamm"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.ejca.2013.07.140","article-title":"Activation of interleukin-6\/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment","volume":"49","author":"C Ren","year":"2013","journal-title":"Eur J Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:25:19Z","timestamp":1589001919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151851"}},"subtitle":[],"editor":[{"given":"Magdalena","family":"Grce","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151851","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}