{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:34:08Z","timestamp":1789439648414,"version":"build-2803163510"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151857","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T17:47:28Z","timestamp":1458236848000},"page":"e0151857","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Amelioration of Diabetic Mouse Nephropathy by Catalpol Correlates with Down-Regulation of Grb10 Expression and Activation of Insulin-Like Growth Factor 1 \/ Insulin-Like Growth Factor 1 Receptor Signaling"],"prefix":"10.1371","volume":"11","author":[{"given":"Shasha","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huacong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunzhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1681\/ASN.2010010010","article-title":"Pathologic classification of diabetic nephropathy","volume":"21","author":"TW Tervaert","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1681\/ASN.V1191667","article-title":"Type 2 diabetic patients with nephropathy show structural-functional Relationships that are similar to type 1 disease","volume":"11","author":"KE White","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"ref3","unstructured":"System URD: USRDS 2012 Annual Data Report:Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2012."},{"issue":"44","key":"ref4","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1038\/sj.onc.1204775","article-title":"The Grb7 family proteins: Structure, interactions with other signaling molecules and potential cellular functions","volume":"20","author":"DC Han","year":"2001","journal-title":"Oncogene"},{"issue":"46","key":"ref5","doi-asserted-by":"crossref","first-page":"29104","DOI":"10.1074\/jbc.272.46.29104","article-title":"Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain- containing insulin receptor binding protein hGrb10gamma","volume":"272","author":"LQ Dong","year":"1997","journal-title":"J Biol Chem"},{"issue":"22","key":"ref6","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1073\/pnas.92.22.10287","article-title":"Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function","volume":"92","author":"F Liu","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1158\/0008-5472.CAN-07-5685","article-title":"Immunity to growth factor receptor-bound protein 10, a signal transduction molecule, inhibits the growth of breast cancer in mice","volume":"68","author":"I O-Sullivan","year":"2008","journal-title":"Cancer Res"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/jcp.24628","article-title":"Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation","volume":"229","author":"N Mokbel","year":"2014","journal-title":"J Cell Physiol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s11033-010-0002-9","article-title":"Grb10 interacts with Bim L and inhibits apoptosis","volume":"37","author":"ZQ Hu","year":"2010","journal-title":"Mol Biol Rep"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"e1005235","DOI":"10.1371\/journal.pgen.1005235","article-title":"Monoallelic. loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+\/- mice","volume":"11","author":"R Mroue","year":"2015","journal-title":"PLoS Genet"},{"issue":"16","key":"ref11","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1128\/MCB.02087-06","article-title":"Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life","volume":"27","author":"FM Smith","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1210\/en.2005-0150","article-title":"The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling","volume":"146","author":"AM Dufresne","year":"2005","journal-title":"Endocrinology"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/1440-1681.12160","article-title":"Growth receptor binding protein 10 inhibits glucose- stimulated insulin release from pancreatic \u03b2-cells associated with suppression of the insulin\/insulin-like growth factor-1 signalling pathway","volume":"40","author":"L Li","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/jne.12040","article-title":"Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats","volume":"25","author":"L Ma","year":"2013","journal-title":"J Neuroendocrinol"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1096\/fj.11-199349","article-title":"Grb10 regulates the development of fiber number in skeletal muscle","volume":"26","author":"LJ Holt","year":"2012","journal-title":"FASEB J"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"e1004235","DOI":"10.1371\/journal.pgen.1004235","article-title":"A central role for GRB10 in regulation of islet function in man","volume":"10","author":"I Prokopenko","year":"2014","journal-title":"PLoS Genet"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2337\/db12-0249","article-title":"Disruption of growth factor receptor- binding protein 10 in the pancreas enhances \u03b2-cell proliferation and protects mice from streptozotocin- induced \u03b2-cell apoptosis","volume":"61","author":"J Zhang","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/jrr\/rrs080","article-title":"Radio-protective effect of catalpol in cultured cells and mice","volume":"54","author":"C Chen","year":"2013","journal-title":"J Radiat Res"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tiv.2012.09.023","article-title":"Catalpol inhibits LPS plus IFN-\u03b3-induced inflammatory response in astrocytes primary cultures","volume":"27","author":"J Bi","year":"2013","journal-title":"Toxicol In Vitro"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/bph.12200","article-title":"Neuroprotection activities of catalpol against CaMKII- dependent apoptosis induced by LPS in PC12 cells","volume":"169","author":"W Chen","year":"2013","journal-title":"Br J Pharmacol"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3760\/cma.j.issn.0366-6999.20132137","article-title":"Relationship between spatial memory in diabetic rats and protein kinase C\u03b3, caveolin-1 in the hippocampus and neuroprotective effect of catalpol","volume":"127","author":"H Zhou","year":"2014","journal-title":"Chin Med J (Engl)"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.phymed.2013.04.007","article-title":"Effect of catalpol on diabetic nephropathy in rats","volume":"20","author":"Z Dong","year":"2013","journal-title":"Phytomedicine"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"e108559","DOI":"10.1371\/journal.pone.0108559","article-title":"Negative Regulation of Grb10 Interacting GYF Protein 2 on Insulin-Like Growth Factor-1 Receptor Signaling Pathway Caused Diabetic Mice Cognitive Impairment","volume":"9","author":"Jing Xie","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.intimp.2014.07.011","article-title":"Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice","volume":"23","author":"Kai Fu","year":"2014","journal-title":"Int Immunopharmacol"},{"issue":"1\u20132","key":"ref25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-8741(00)00202-6","article-title":"Hypoglycemic effect of extracts and fractions from Psaealium decompositurn in healthy and alloxan-diabetic mice","volume":"72","author":"FJ Alarcon-Aguilar","year":"2000","journal-title":"J Ethnopharmaeol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1139\/o03-078","article-title":"Diabetes, lipids, and adipocyte secretagogues","volume":"82","author":"M Faraj","year":"2004","journal-title":"Biochem Cell Biol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.atherosclerosis.2004.01.016","article-title":"The effect of high dose atorvastatin therapy on lipids and lipoprotein subfractions in overweight patients with type 2 diabetes","volume":"174","author":"JM Lawrence","year":"2004","journal-title":"Atherosclerosis"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbadis.2014.06.030","article-title":"Interplay of oxidative, nitrosative\/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy","volume":"1852","author":"ZV Varga","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"19394","DOI":"10.3390\/ijms151119394","article-title":"Catalpol Suppresses Proliferation and Facilitates Apoptosis of OVCAR-3 Ovarian Cancer Cells through Upregulating MicroRNA-200 and Downregulating MMP-2 Expression","volume":"15","author":"N Gao","year":"2014","journal-title":"Int. J. Mol. Sci"},{"issue":"2","key":"ref30","first-page":"2038","article-title":"Catalpol protects mice against renal ischemia \/ reperfusion injury via suppressing PI3K\/Akt-eNOS signaling and inflammation","volume":"8","author":"Jili Zhu","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jep.2013.11.025","article-title":"Renoprotection of Danshen Injection on streptozotocin-induced diabetic rats, associated with tubular function and structure","volume":"151","author":"D Yin","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jep.2010.07.057","article-title":"Andrographolide and 14-deoxy-11,12- didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines","volume":"132","author":"MJ Lee","year":"2010","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40360-015-0040-y","article-title":"Heme oxygenase-1 attenuates cadmium-induced mitochondrial-caspase 3- dependent apoptosis in human hepatoma cell line","volume":"16","author":"AO Lawal","year":"2015","journal-title":"BMC Pharmacol Toxicol"},{"issue":"41","key":"ref34","doi-asserted-by":"crossref","first-page":"39311","DOI":"10.1074\/jbc.M304599200","article-title":"Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action","volume":"278","author":"Y Deng","year":"2003","journal-title":"J Biol Chem"},{"issue":"6035","key":"ref35","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.1199484","article-title":"Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb10 as an mTORC1 Substrate that Negatively Regulates Insulin Signaling","volume":"332","author":"Y Yu","year":"2011","journal-title":"Science"},{"issue":"34","key":"ref36","doi-asserted-by":"crossref","first-page":"31564","DOI":"10.1074\/jbc.M211572200","article-title":"Two novel proteins that are linked to insulin- like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling","volume":"278","author":"B Giovannone","year":"2003","journal-title":"J Biol Chem"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00467-013-2570-0","article-title":"The utility of the IGF-1 generation test in children with chronic kidney disease","volume":"28","author":"A Al-Uzri","year":"2013","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.15252\/emmm.201404916","article-title":"Inhibition of insulin\/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure","volume":"7","author":"C Ising","year":"2015","journal-title":"EMBO Mol Med"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1152\/ajprenal.00137.2002","article-title":"High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism","volume":"284","author":"BP Kang","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"F1144","DOI":"10.1152\/ajprenal.00094.2005","article-title":"Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination","volume":"289","author":"S Yang","year":"2005","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:27:48Z","timestamp":1718418468000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151857"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Caporali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151857","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}