{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:10:12Z","timestamp":1778055012376,"version":"3.51.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152169","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T18:13:21Z","timestamp":1458756801000},"page":"e0152169","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peptidomimetic Star Polymers for Targeting Biological Ion Channels"],"prefix":"10.1371","volume":"11","author":[{"given":"Rong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongfan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Coote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.drudis.2009.10.009","article-title":"Synthetic therapeutic peptides: science and market","volume":"15","author":"P Vlieghe","year":"2010","journal-title":"Drug Discov Today"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"46590","DOI":"10.1074\/jbc.M308615200","article-title":"Synthetic peptides in the form of dendrimers become resistant to protease activity","volume":"278","author":"L Bracci","year":"2003","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/aid.2005.21.207","article-title":"SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques","volume":"21","author":"YH Jiang","year":"2005","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1128\/AAC.44.9.2471-2474.2000","article-title":"Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection","volume":"44","author":"N Bourne","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1021\/bm400626w","article-title":"Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer","volume":"14","author":"TY Liu","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1002\/anie.201002221","article-title":"Polyacrylate dendrimer nanoparticles: a self-adjuvanting vaccine delivery system","volume":"49","author":"M Skwarczynski","year":"2010","journal-title":"Angew Chem Int Ed"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.200709946","article-title":"Ion channels as drug targets: The next GPCRs","volume":"131","author":"GJ Kaczorowski","year":"2008","journal-title":"J Gen Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0031-6997(24)01469-8","article-title":"Potassium channels: molecular defects, diseases, and therapeutic opportunities","volume":"52","author":"CC Shieh","year":"2000","journal-title":"Pharmacol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1476-5381.2009.00437.x","article-title":"Subtype-selective targeting of voltage-gated sodium channels","volume":"158","author":"S England","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/nedt.2007.3.1.69","article-title":"Ziconotide: a review of its pharmacology and use in the treatment of pain","volume":"3","author":"JG McGivern","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2011.07.016","article-title":"Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases","volume":"59","author":"V Chi","year":"2012","journal-title":"Toxicon"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.coph.2006.04.006","article-title":"Antibacterial peptides for therapeutic use: obstacles and realistic outlook","volume":"6","author":"AK Marr","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The structure of the potassium channel: molecular basis of K<sup>+<\/sup> conduction and selectivity","volume":"280","author":"DA Doyle","year":"1998","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1116269","article-title":"Crystal structure of a mammalian voltage-dependent <italic>Shaker<\/italic> family K<sup>+<\/sup> channel","volume":"309","author":"SB Long","year":"2005","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature10238","article-title":"The crystal structure of a voltage-gated sodium channel","volume":"475","author":"J Payandeh","year":"2011","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1720574","article-title":"Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins","volume":"254","author":"F Bontems","year":"1991","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00035.2012","article-title":"Computational methods of studying the binding of toxins from venomous animals to biological ion channels: theory and applications","volume":"93","author":"D Gordon","year":"2013","journal-title":"Physiol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e00594","DOI":"10.7554\/eLife.00594","article-title":"Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K<sup>+<\/sup> channel","volume":"2","author":"A Banerjee","year":"2013","journal-title":"elife"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI16921","article-title":"The voltage-gated Kv1.3 K<sup>+<\/sup> channel in effector memory T cells as new target for MS","volume":"111","author":"H Wulff","year":"2003","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"C Beeton","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.bpj.2011.10.029","article-title":"Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3)","volume":"101","author":"R Chen","year":"2011","journal-title":"Biophys J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e47253","DOI":"10.1371\/journal.pone.0047253","article-title":"Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations","volume":"7","author":"R Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/jcc.540130812","article-title":"The weighted histogram analysis method for free-energy calculations on biomolecules. I. The method","volume":"13","author":"S Kumar","year":"1992","journal-title":"J Comput Chem"},{"key":"ref24","unstructured":"Grossfield A. &quot;WHAM: the weighted histogram analysis method&quot;, version 2.0.9 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/membrane.urmc.rochester.edu\/content\/wham2013\" xlink:type=\"simple\">http:\/\/membrane.urmc.rochester.edu\/content\/wham2013<\/ext-link> [7 March 2016]."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1021\/ct100494z","article-title":"g_wham-A free weighted histogram analysis implementation including robust error and autocorrelation estimates","volume":"6","author":"JS Hub","year":"2010","journal-title":"J Chem Theory Comput"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1021\/acs.macromol.5b00195","article-title":"One-pot orthogonal copper-catalyzed synthesis and self-assembly of L-lysine-decorated polymeric dendrimers","volume":"48","author":"D Lu","year":"2015","journal-title":"Macromolecules"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature06265","article-title":"Atomic structure of a voltage-dependent K<sup>+<\/sup> channel in a lipid membrane-like environment","volume":"450","author":"SB Long","year":"2007","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-895X(25)10594-4","article-title":"Pharmacological characterization of five cloned voltage-gated K<sup>+<\/sup> channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines","volume":"45","author":"S Grissmer","year":"1994","journal-title":"Mol Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1042\/BST0351060","article-title":"hERG channel trafficking: novel targets in drug-induced long QT syndrome","volume":"35","author":"A Dennis","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1021\/cr300360k","article-title":"Ion channel associated diseases: overview of molecular mechanisms","volume":"112","author":"MA Zaydman","year":"2012","journal-title":"Chem Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/jm3011433","article-title":"Ion channels as therapeutic targets: A drug discovery perspective","volume":"56","author":"S Bagal","year":"2013","journal-title":"J Med Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/bph.13081","article-title":"Seven novel modulators of the analgesic target Na<sub>V<\/sub>1.7 uncovered using a high-throughput venom-based discovery approach","volume":"172","author":"JK Klint","year":"2015","journal-title":"Br J Pharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ncomms1795","article-title":"Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons","volume":"3","author":"MS Minett","year":"2012","journal-title":"Nat Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T22:53:23Z","timestamp":1748818403000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152169"}},"subtitle":[],"editor":[{"given":"Alexander G","family":"Obukhov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152169","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}