{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:53:12Z","timestamp":1790297592742,"version":"4.1.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152177","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T14:13:50Z","timestamp":1458742430000},"page":"e0152177","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Differential Regulation of TLR Signaling on the Induction of Antiviral Interferons in Human Intestinal Epithelial Cells Infected with Enterovirus 71"],"prefix":"10.1371","volume":"11","author":[{"given":"Chunyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol J.","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"T Solomon","year":"2010","journal-title":"The Lancet infectious diseases"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0022-3476(98)70155-6","article-title":"Fatal enterovirus 71 encephalomyelitis","volume":"133","author":"LC Lum","year":"1998","journal-title":"J Pediatr"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"PC McMinn","year":"2002","journal-title":"FEMS microbiology reviews"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/1040841X.2011.580723","article-title":"The virology and developments toward control of human enterovirus 71","volume":"37","author":"L Yi","year":"2011","journal-title":"Critical reviews in microbiology"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1462-5822.2006.00716.x","article-title":"Interferon signalling network in innate defence","volume":"8","author":"A Takaoka","year":"2006","journal-title":"Cellular microbiology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL-28, IL-29 and their class II cytokine receptor IL-28R","volume":"4","author":"P Sheppard","year":"2003","journal-title":"Nature immunology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling","volume":"13","author":"T Kawai","year":"2006","journal-title":"Cell death and differentiation"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.4049\/jimmunol.175.8.5260","article-title":"The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I","volume":"175","author":"S Rothenfusser","year":"2005","journal-title":"J Immunol"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.4049\/jimmunol.175.5.2851","article-title":"Shared and unique functions of the DExD\/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity","volume":"175","author":"M Yoneyama","year":"2005","journal-title":"J Immunol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/BJ20131492","article-title":"Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses","volume":"458","author":"M Tatematsu","year":"2014","journal-title":"The Biochemical journal"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"MR Thompson","year":"2011","journal-title":"Viruses"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.4049\/jimmunol.171.8.4304","article-title":"Toll\/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling","volume":"171","author":"S Sato","year":"2003","journal-title":"J Immunol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1061","article-title":"RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation","volume":"5","author":"E Meylan","year":"2004","journal-title":"Nature immunology"},{"issue":"7073","key":"ref14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature04369","article-title":"Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6","volume":"439","author":"H Hacker","year":"2006","journal-title":"Nature"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"S Akira","year":"2006","journal-title":"Cell"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"S Akira","year":"2004","journal-title":"Nature reviews Immunology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"LA O'Neill","year":"2007","journal-title":"Nature reviews Immunology"},{"issue":"17","key":"ref18","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1128\/JVI.00447-11","article-title":"Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3","volume":"85","author":"X Lei","year":"2011","journal-title":"Journal of virology"},{"key":"ref19","article-title":"Robust Antiviral Responses to Enterovirus 71 Infection in Human Intestinal Epithelial Cells","author":"C Chi","year":"2013","journal-title":"Virus research"},{"issue":"16","key":"ref20","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1128\/JVI.02491-09","article-title":"The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses","volume":"84","author":"X Lei","year":"2010","journal-title":"Journal of virology"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","article-title":"Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche","volume":"162","author":"G K\u00e4rber","year":"1931","journal-title":"Naunyn-Schmiedebergs Archiv f\u00fcr experimentelle pathologie und pharmakologie"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virusres.2014.12.016","article-title":"Regulation of host responses and viral replication by the mitogen-activated protein kinases in intestinal epithelial cells infected with Enterovirus 71","volume":"197","author":"C Wang","year":"2015","journal-title":"Virus Res"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tim.2013.04.004","article-title":"Innate immune detection of microbial nucleic acids","volume":"21","author":"C Gurtler","year":"2013","journal-title":"Trends in microbiology"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1349-7006.2003.tb01455.x","article-title":"New aspects of IFN-alpha\/beta signalling in immunity, oncogenesis and bone metabolism","volume":"94","author":"A Takaoka","year":"2003","journal-title":"Cancer science"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cytogfr.2014.06.002","article-title":"Tyrosine phosphorylation in Toll-like receptor signaling","volume":"25","author":"S Chattopadhyay","year":"2014","journal-title":"Cytokine & growth factor reviews"},{"issue":"17","key":"ref27","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1128\/JVI.00236-07","article-title":"Retrograde axonal transport: a major transmission route of enterovirus 71 in mice","volume":"81","author":"CS Chen","year":"2007","journal-title":"Journal of virology"},{"issue":"Pt 12","key":"ref28","first-page":"3263","article-title":"Type I interferons protect mice against enterovirus 71 infection","volume":"86","author":"ML Liu","year":"2005","journal-title":"The Journal of general virology"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/JVI.01855-12","article-title":"Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses","volume":"87","author":"X Lei","year":"2013","journal-title":"J Virol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"e1003231","DOI":"10.1371\/journal.ppat.1003231","article-title":"Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses","volume":"9","author":"B Wang","year":"2013","journal-title":"PLoS pathogens"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"e63431","DOI":"10.1371\/journal.pone.0063431","article-title":"MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation","volume":"8","author":"RL Kuo","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20042372","article-title":"Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction","volume":"201","author":"S Uematsu","year":"2005","journal-title":"J Exp Med"},{"issue":"20","key":"ref33","doi-asserted-by":"crossref","first-page":"11658","DOI":"10.1128\/JVI.00867-14","article-title":"Toll-like receptor 9-mediated protection of enterovirus 71 infection in mice is due to the release of danger-associated molecular patterns","volume":"88","author":"HB Hsiao","year":"2014","journal-title":"J Virol"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jmb.2013.11.024","article-title":"Toll-like receptors in antiviral innate immunity","volume":"426","author":"SN Lester","year":"2014","journal-title":"J Mol Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:26:29Z","timestamp":1540211189000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152177"}},"subtitle":[],"editor":[{"given":"Kui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152177","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}