{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:47:26Z","timestamp":1767844046177,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152191","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T17:43:06Z","timestamp":1458841386000},"page":"e0152191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Masayuki","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Higashino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Numata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songji","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kuge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/86573","article-title":"Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues","volume":"7","author":"M Stoeckli","year":"2001","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1021\/ac402108x","article-title":"Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues","volume":"85","author":"TW Powers","year":"2013","journal-title":"Anal Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11306-013-0588-8","article-title":"Integrated MALDI-MS imaging and LC-MS techniques for visualizing spatiotemporal metabolomic dynamics in a rat stroke model","volume":"10","author":"M Irie","year":"2014","journal-title":"Metabolomics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.bbalip.2011.03.004","article-title":"Imaging mass spectrometry for lipidomics","volume":"1811","author":"N Goto-Inoue","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"16802","DOI":"10.1038\/srep16802","article-title":"The accumulation mechanism of the hypoxia imaging probe &quot;FMISO&quot; by imaging mass spectrometry: possible involvement of low-molecular metabolites","volume":"5","author":"Y Masaki","year":"2015","journal-title":"Sci Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1194\/jlr.M900047-JLR200","article-title":"Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry","volume":"50","author":"Y Sugiura","year":"2009","journal-title":"J Lipid Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1194\/jlr.M044990","article-title":"Spatial organization of lipids in the human retina and optic nerve by MALDI imaging mass spectrometry","volume":"55","author":"KA Zemski Berry","year":"2014","journal-title":"J Lipid Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1021\/ac501937d","article-title":"On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging","volume":"86","author":"EE Jones","year":"2014","journal-title":"Anal Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.jasms.2010.08.002","article-title":"The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles","volume":"21","author":"N Goto-Inoue","year":"2010","journal-title":"J Am Soc Mass Spectrom"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1021\/ac800617s","article-title":"MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue","volume":"80","author":"DS Cornett","year":"2008","journal-title":"Anal Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1021\/ac902931x","article-title":"A strategy for the determination of the elemental composition by fourier transform ion cyclotron resonance mass spectrometry based on isotopic peak ratios","volume":"82","author":"D Miura","year":"2010","journal-title":"Anal Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.bbalip.2015.09.004","article-title":"Histological analyses by matrix-assisted laser desorption\/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains","volume":"1851","author":"M Sugimoto","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.20041685","article-title":"Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis","volume":"202","author":"M Miyaji","year":"2005","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1194\/jlr.M059972","article-title":"Analysis of lipid-composition changes in plasma membrane microdomains","volume":"56","author":"H Ogiso","year":"2015","journal-title":"J Lipid Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.319","article-title":"Mammalian ceramide synthases","volume":"62","author":"M Levy","year":"2010","journal-title":"IUBMB Life"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1743-7075-9-71","article-title":"Mechanisms involved in cellular ceramide homeostasis","volume":"9","author":"MM Hussain","year":"2012","journal-title":"Nutr Metab (Lond)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbalip.2013.12.003","article-title":"The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration-from cell and animal models to human disorders","volume":"1841","author":"M Taniguchi","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1021\/cn500174c","article-title":"Chronic ethanol consumption profoundly alters regional brain ceramide and sphingomyelin content in rodents","volume":"6","author":"A Roux","year":"2015","journal-title":"ACS Chem Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9998","DOI":"10.1073\/pnas.1217775110","article-title":"Sulfatides are required for renal adaptation to chronic metabolic acidosis","volume":"110","author":"P Stettner","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1046\/j.1523-1755.63.s84.5.x","article-title":"Fabry disease: diagnosis and treatment","author":"F Breunig","year":"2003","journal-title":"Kidney Int Supp"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00216-014-8402-7","article-title":"Fabry disease: renal sphingolipid distribution in the alpha-Gal A knockout mouse model by mass spectrometric and immunohistochemical imaging","volume":"407","author":"L Kuchar","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1194\/jlr.M055269","article-title":"Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice","volume":"56","author":"A Bickert","year":"2015","journal-title":"J Lipid Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ki.2015.3","article-title":"Lipid imaging within the normal rat kidney using silver nanoparticles by matrix-assisted laser desorption\/ionization mass spectrometry","volume":"88","author":"L Muller","year":"2015","journal-title":"Kidney Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/ATVBAHA.109.185223","article-title":"Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice","volume":"29","author":"J Liu","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1128\/MCB.05893-11","article-title":"Reducing plasma membrane sphingomyelin increases insulin sensitivity","volume":"31","author":"Z Li","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/ATVBAHA.113.301498","article-title":"Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor gamma2 suppression","volume":"33","author":"Y Li","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"28544","DOI":"10.1074\/jbc.M111.255646","article-title":"Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes","volume":"286","author":"S Mitsutake","year":"2011","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1194\/jlr.M300331-JLR200","article-title":"Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS\/MS: identification of ceramides containing sphingadienine","volume":"45","author":"B Colsch","year":"2004","journal-title":"J Lipid Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1007\/s00216-014-8232-7","article-title":"A spiked tissue-based approach for quantification of phosphatidylcholines in brain section by MALDI mass spectrometry imaging","volume":"407","author":"L Jadoul","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.biochi.2013.07.017","article-title":"Ectopic lipid accumulation: A potential cause for metabolic disturbances and a contributor to the alteration of kidney function","volume":"95","author":"F Guebre-Egziabher","year":"2013","journal-title":"Biochimie"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.2337\/db09-1293","article-title":"Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption","volume":"59","author":"JR Ussher","year":"2010","journal-title":"Diabetes"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/ki.1997.304","article-title":"Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure","volume":"52","author":"RA Zager","year":"1997","journal-title":"Kidney Int"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1523-1755.1998.00772.x","article-title":"Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure","volume":"53","author":"RA Zager","year":"1998","journal-title":"Kidney Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1124\/jpet.110.168815","article-title":"Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet","volume":"334","author":"KM Boini","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cmet.2014.08.002","article-title":"Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance","volume":"20","author":"SM Turpin","year":"2014","journal-title":"Cell Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/hep.26015","article-title":"Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes","volume":"57","author":"JW Park","year":"2013","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cmet.2014.09.015","article-title":"CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance","volume":"20","author":"S Raichur","year":"2014","journal-title":"Cell Metab"},{"key":"ref38","first-page":"1157","article-title":"Induction of peroxisomal lipid metabolism in mice fed a high-fat diet","volume":"4","author":"S Kozawa","year":"2011","journal-title":"Mol Med Rep"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"33549","DOI":"10.1074\/jbc.M109.031971","article-title":"Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas","volume":"284","author":"S Imgrund","year":"2009","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"21433","DOI":"10.1074\/jbc.M113.479907","article-title":"Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities","volume":"288","author":"P Ebel","year":"2013","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejphar.2015.03.026","article-title":"Translational value of animal models of kidney failure","volume":"759","author":"A Ortiz","year":"2015","journal-title":"Eur J Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T08:19:25Z","timestamp":1718439565000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152191"}},"subtitle":[],"editor":[{"given":"Maurizio","family":"Del Poeta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,24]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,24]]}}}