{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:01:45Z","timestamp":1792101705323,"version":"4.4.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152249","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T17:54:10Z","timestamp":1458842050000},"page":"e0152249","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study"],"prefix":"10.1371","volume":"11","author":[{"given":"Jeffrey M.","family":"Sequeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankuri","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Berrocal-Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan D.","family":"Fernandez-Ballart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V.","family":"Quadros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.19.1.1","article-title":"An account of 335 cases of megaloblastic anaemia of pregnancy and the puerperium","volume":"19","author":"C Giles","year":"1966","journal-title":"J Clin Pathol"},{"issue":"5 Suppl","key":"ref2","doi-asserted-by":"crossref","first-page":"1295s","DOI":"10.1093\/ajcn\/71.5.1295s","article-title":"Folic acid: influence on the outcome of pregnancy","volume":"71","author":"TO Scholl","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"8760","key":"ref3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","volume":"338","year":"1991","journal-title":"Lancet"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/bdra.20111","article-title":"Behavioral effects of prenatal folate deficiency in mice","volume":"73","author":"SA Ferguson","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1017\/S0007114514002116","article-title":"Folate deficiency in rat pups during weaning causes learning and memory deficits","volume":"112","author":"MI Berrocal-Zaragoza","year":"2014","journal-title":"Br J Nutr"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1093\/jn\/132.11.3418","article-title":"Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain","volume":"132","author":"JM Kim","year":"2002","journal-title":"J Nutr"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","article-title":"Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease","volume":"22","author":"II Kruman","year":"2002","journal-title":"J Neurosci"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/13861","article-title":"Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development","volume":"23","author":"JA Piedrahita","year":"1999","journal-title":"Nat Genet"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1073\/pnas.1211199110","article-title":"Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice","volume":"110","author":"J Momb","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJMoa031145","article-title":"Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect","volume":"350","author":"SP Rothenberg","year":"2004","journal-title":"N Engl J Med"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-2007-991148","article-title":"Folate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome","volume":"38","author":"VT Ramaekers","year":"2007","journal-title":"Neuropediatrics"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1055\/s-2008-1065354","article-title":"Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits","volume":"38","author":"VT Ramaekers","year":"2007","journal-title":"Neuropediatrics"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/bdra.10088","article-title":"Antibodies to folate receptors impair embryogenesis and fetal development in the rat","volume":"67","author":"M da Costa","year":"2003","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jri.2008.08.002","article-title":"Autoantibodies to folate receptor during pregnancy and neural tube defect risk","volume":"79","author":"RM Cabrera","year":"2008","journal-title":"J Reprod Immunol"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1093\/humrep\/der144","article-title":"Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway","volume":"26","author":"AL Boyles","year":"2011","journal-title":"Hum Reprod"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1056\/NEJMoa0803783","article-title":"Lack of association between folate-receptor autoantibodies and neural-tube defects","volume":"361","author":"AM Molloy","year":"2009","journal-title":"N Engl J Med"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1203\/PDR.0b013e3181cbd564","article-title":"Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark","volume":"67","author":"C Bille","year":"2010","journal-title":"Pediatr Res"},{"issue":"19","key":"ref18","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa043160","article-title":"Autoantibodies to folate receptors in the cerebral folate deficiency syndrome","volume":"352","author":"VT Ramaekers","year":"2005","journal-title":"N Engl J Med"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1469-8749.2004.tb00451.x","article-title":"Cerebral folate deficiency","volume":"46","author":"VT Ramaekers","year":"2004","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/mp.2011.175","article-title":"Cerebral folate receptor autoantibodies in autism spectrum disorder","volume":"18","author":"RE Frye","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/mp.2012.22","article-title":"Role of folate receptor autoantibodies in infantile autism","volume":"18","author":"VT Ramaekers","year":"2013","journal-title":"Molecular Psychiatry"},{"issue":"7398","key":"ref22","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0140-6736(65)91895-7","article-title":"Folic acid metabolism and human embryopathy","volume":"285","author":"E Hibbard","year":"1965","journal-title":"The Lancet"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/adc.51.12.944","article-title":"Vitamin dificiencies and neural tube defects","volume":"51","author":"RW Smithells","year":"1976","journal-title":"Arch Dis Child"},{"issue":"1\u20132","key":"ref24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-1119(00)00262-6","article-title":"Coding sequence, genomic organization and expression of a folate binding protein gene in the rat","volume":"254","author":"E Sadasivan","year":"2000","journal-title":"Gene"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0304-4165(87)90145-0","article-title":"Purification, properties, and immunological characterization of folate-binding proteins from human leukemia cells","volume":"925","author":"E Sadasivan","year":"1987","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The Open-Field Test: a critical review","volume":"83","author":"RN Walsh","year":"1976","journal-title":"Psychol Bull"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1","volume":"31","author":"A Ennaceur","year":"1988","journal-title":"Behavioral data. Behav Brain Res"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nlm.2004.03.005","article-title":"On the delay-dependent involvement of the hippocampus in object recognition memory","volume":"82","author":"RS Hammond","year":"2004","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-0270(00)00288-0","article-title":"Passive and active place avoidance as a tool of spatial memory research in rats","volume":"102","author":"JM Cimadevilla","year":"2000","journal-title":"J Neurosci Methods"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0361-9230(01)00448-8","article-title":"New spatial cognition tests for mice: passive place avoidance on stable and active place avoidance on rotating arenas","volume":"54","author":"JM Cimadevilla","year":"2001","journal-title":"Brain Res Bull"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2009.05.034","article-title":"A hierarchy of neurobehavioral tasks discriminates between mild and moderate brain injury in rats","volume":"1280","author":"SG Abdel Baki","year":"2009","journal-title":"Brain Res"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2008.09.005","article-title":"Retrosplenial cortex lesion affected segregation of spatial information in place avoidance task in the rat","volume":"91","author":"M Wesierska","year":"2009","journal-title":"Neurobiol Learn Mem"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.55782\/ane-2004-1526","article-title":"Experimental modeling of anxiety and depression","volume":"64","author":"AV Kalueff","year":"2004","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1037\/0735-7044.113.3.507","article-title":"Effects of lesions to the hippocampus on contextual fear: evidence for a disruption of freezing and avoidance behavior but not context conditioning","volume":"113","author":"P Gisquet-Verrier","year":"1999","journal-title":"Behav Neurosci"},{"issue":"1\u20132","key":"ref35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0166-4328(02)00046-3","article-title":"Cholinergic activation of the basolateral amygdala regulates unlearned freezing behavior in rats","volume":"134","author":"AE Power","year":"2002","journal-title":"Behav Brain Res"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(99)00441-0","article-title":"Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats","volume":"378","author":"S Hashimoto","year":"1999","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/NI:5:1:79","article-title":"Web-based method for translating neurodevelopment from laboratory species to humans","volume":"5","author":"B Clancy","year":"2007","journal-title":"Neuroinformatics"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1469-8749.2008.02053.x","article-title":"A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome","volume":"50","author":"VT Ramaekers","year":"2008","journal-title":"Dev Med Child Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T08:19:56Z","timestamp":1718439596000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152249"}},"subtitle":[],"editor":[{"given":"Georges","family":"Chapouthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,24]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152249","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,24]]}}}