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TW. Lao PDR World Development Indicators 2015 [cited 2015 October 20 2015]. Available from: http:\/\/data.worldbank.org\/country\/lao-pdr<\/ext-link>."},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijantimicag.2005.04.017","article-title":"A systematic review and meta-analysis of misuse of antibiotic therapies in the community","volume":"26","author":"P Kardas","year":"2005","journal-title":"International journal of antimicrobial agents"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1473-3099(05)70189-4","article-title":"Antimicrobial resistance in developing countries. 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