{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:09Z","timestamp":1791295689406,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152483","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T17:31:57Z","timestamp":1459531917000},"page":"e0152483","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Combined Analysis of IFN-\u03b3, IL-2, IL-5, IL-10, IL-1RA and MCP-1 in QFT Supernatant Is Useful for Distinguishing Active Tuberculosis from Latent Infection"],"prefix":"10.1371","volume":"11","author":[{"given":"Maho","family":"Suzukawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hebisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"ref1","unstructured":"Global Tuberculosis Report 2014. World Health Organization 2014. 2014."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9223","DOI":"10.1038\/srep09223","article-title":"IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection","volume":"5","author":"K Tonby","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jinf.2014.12.019","article-title":"IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy","volume":"70","author":"I Wergeland","year":"2015","journal-title":"The Journal of infection"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JCM.02758-14","article-title":"Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production","volume":"53","author":"YH Jeong","year":"2015","journal-title":"J Clin Microbiol"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/thx.2009.126771","article-title":"Systematic review of interferon-gamma release assays in tuberculosis: focus on likelihood ratios","volume":"65","author":"KC Chang","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.5588\/ijtld.13.0688","article-title":"Tuberculosis Epidemiologic Studies Consortium Task Order T. Risk factors for treatment default in close contacts with latent tuberculous infection","volume":"18","author":"CT Fiske","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"issue":"18","key":"ref7","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1073\/pnas.0600349103","article-title":"Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations","volume":"103","author":"T Cohen","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201201-0037OC","article-title":"Combination biomarkers to diagnose sepsis in the critically ill patient","volume":"186","author":"S Gibot","year":"2012","journal-title":"American journal of respiratory and critical care medicine"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1183\/09031936.00181610","article-title":"Are interferon-gamma release assays useful for diagnosing active tuberculosis in a high-burden setting?","volume":"38","author":"DI Ling","year":"2011","journal-title":"The European respiratory journal"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3109\/00365548.2014.927955","article-title":"Comparison of IGRA tests and TST in the diagnosis of latent tuberculosis infection and predicting tuberculosis in risk groups in Krakow, Poland","volume":"46","author":"K Kruczak","year":"2014","journal-title":"Scandinavian journal of infectious diseases"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-149-3-200808050-00241","article-title":"Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update","volume":"149","author":"M Pai","year":"2008","journal-title":"Annals of internal medicine"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"e79742","DOI":"10.1371\/journal.pone.0079742","article-title":"Combination of cytokine responses indicative of latent TB and active TB in Malawian adults","volume":"8","author":"YG Hur","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"PS Redford","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.4049\/jimmunol.1202722","article-title":"IL-10 inhibits mature fibrotic granuloma formation during Mycobacterium tuberculosis infection","volume":"190","author":"JC Cyktor","year":"2013","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1183\/09031936.00151413","article-title":"Beyond the IFN-gamma horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis","volume":"43","author":"NN Chegou","year":"2014","journal-title":"The European respiratory journal"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.20050126","article-title":"A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis","volume":"202","author":"PO Flores-Villanueva","year":"2005","journal-title":"The Journal of experimental medicine"},{"issue":"4\u20135","key":"ref17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1359-6101(02)00020-5","article-title":"The balance between IL-1 and IL-1Ra in disease","volume":"13","author":"WP Arend","year":"2002","journal-title":"Cytokine & growth factor reviews"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.4049\/jimmunol.156.7.2503","article-title":"IL-1 receptor antagonist (IL-1ra) expression, function, and cytokine-mediated regulation during mycobacterial and schistosomal antigen-elicited granuloma formation","volume":"156","author":"JH Ruth","year":"1996","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1164\/ajrccm.157.4.9709126","article-title":"Tumor necrosis factor and interleukin-1 inhibitors as markers of disease activity of tuberculosis","volume":"157","author":"NP Juffermans","year":"1998","journal-title":"American journal of respiratory and critical care medicine"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1378\/chest.117.1.103","article-title":"Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis","volume":"117","author":"TC Tsao","year":"2000","journal-title":"Chest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-0500-2-19","article-title":"IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based","volume":"2","author":"M Ruhwald","year":"2009","journal-title":"T-cell assay. BMC research notes"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1164\/rccm.201501-0059OC","article-title":"Mycobacteria-Specific Cytokine Responses Detect Tuberculosis Infection and Distinguish Latent from Active Tuberculosis","volume":"192","author":"M Tebruegge","year":"2015","journal-title":"American journal of respiratory and critical care medicine"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"e64226","DOI":"10.1371\/journal.pone.0064226","article-title":"Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting","volume":"8","author":"NN Chegou","year":"2013","journal-title":"PloS one"},{"issue":"5","key":"ref24","first-page":"L536","article-title":"Expression and regulation of human pulmonary fibroblast-derived monocyte chemotactic peptide-1","volume":"263","author":"MW Rolfe","year":"1992","journal-title":"Am J Physiol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/1523-1747.ep12616653","article-title":"Human dermal fibroblast interleukin-1 receptor antagonist (IL-1ra) and interleukin-1 beta (IL-1 beta) mRNA and protein are co-stimulated by phorbol ester: implication for a homeostatic mechanism","volume":"99","author":"LS Chan","year":"1992","journal-title":"J Invest Dermatol"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/1529-0131(199907)42:7<1508::AID-ANR26>3.0.CO;2-L","article-title":"Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"42","author":"S Harada","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jinf.2012.11.005","article-title":"Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection","volume":"66","author":"A Mihret","year":"2013","journal-title":"The Journal of infection"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2466-9-21","article-title":"Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report","volume":"9","author":"NN Chegou","year":"2009","journal-title":"BMC pulmonary medicine"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1469-0691.2009.03104.x","article-title":"Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls","volume":"16","author":"R Biselli","year":"2010","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"e43438","DOI":"10.1371\/journal.pone.0043438","article-title":"Immune responses to ESAT-6 and CFP-10 by FASCIA and multiplex technology for diagnosis of M. tuberculosis infection; IP-10 is a promising marker","volume":"7","author":"E Borgstrom","year":"2012","journal-title":"PloS one"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"e76091","DOI":"10.1371\/journal.pone.0076091","article-title":"Baseline levels and temporal stability of 27 multiplexed serum cytokine concentrations in healthy subjects","volume":"8","author":"A Biancotto","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jinf.2015.08.001","article-title":"Serum IP-10 in the diagnosis of latent and active tuberculosis","volume":"71","author":"V Clifford","year":"2015","journal-title":"The Journal of infection"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T12:39:10Z","timestamp":1692275950000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152483"}},"subtitle":[],"editor":[{"given":"Katalin Andrea","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,1]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152483","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,1]]}}}