{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:39:26Z","timestamp":1759178366118},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152604","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T14:55:14Z","timestamp":1460040914000},"page":"e0152604","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses"],"prefix":"10.1371","volume":"11","author":[{"given":"Shea N.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Be","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Forrester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Guerbois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Jaing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.ento.49.061802.123422","article-title":"Venezuelan equine encephalitis","volume":"49","author":"SC Weaver","year":"2004","journal-title":"Annu Rev Entomol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1371\/journal.pntd.0000472","article-title":"Venezuelan equine encephalitis in Panama: fatal endemic disease and genetic diversity of etiologic viral strains","volume":"3","author":"E Quiroz","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3201\/eid1603.090970","article-title":"Venezuelan equine encephalitis and 2 human deaths","volume":"16","author":"S Vilcarromero","year":"2010","journal-title":"Peru Emerg Infect Dis"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4269\/ajtmh.1968.17.432","article-title":"Recovery of Venezuelan equine encephalomyelitis virus in Panama. A fatal case in man","volume":"17","author":"KM Johnson","year":"1968","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"2","key":"ref5","first-page":"234","article-title":"Mosquitos (Diptera: Culicidae) in the small village where a human case of Venezuelan equine encephalitis was recorded","volume":"28","author":"C Ferro","year":"2008","journal-title":"Biomedica"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1005.030634","article-title":"Endemic Venezuelan Equine Encephalitis in Northern Peru","volume":"10","author":"PV Aguilar","year":"2004","journal-title":"Emerging Infectious Diseases"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1371\/journal.pntd.0000787","article-title":"Arboviral Etiologies of Acute Febrile Illnesses in Western South America, 2000\u20132007","volume":"4","author":"BM Forshey","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3201\/eid1502.081018","article-title":"Venezuelan Equine Encephalitis and Upper Gastrointestinal Bleeding in Child","volume":"15","author":"S Vilcarromero","year":"2009","journal-title":"Emerging Infectious Diseases"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.4269\/ajtmh.1997.56.661","article-title":"Venezuelan equine encephalitis and Oropouche virus infections among Peruvian army troops in the Amazon region of Peru","volume":"56","author":"DM Watts","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4269\/ajtmh.1998.58.35","article-title":"Venezuelan equine encephalitis febrile cases among humans in the Peruvian Amazon River region","volume":"58","author":"DM Watts","year":"1998","journal-title":"Am J Trop Med Hyg"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1073\/pnas.0509961103","article-title":"Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation","volume":"103","author":"M Anishchenko","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/JVI.76.4.1718-1730.2002","article-title":"Positively Charged Amino Acid Substitutions in the E2 Envelope Glycoprotein Are Associated with the Emergence of Venezuelan Equine Encephalitis Virus","volume":"76","author":"AC Brault","year":"2002","journal-title":"Journal of Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4172\/2157-7145.1000107","article-title":"Scalable SNP Analyses of 100+ Bacterial or Viral Genomes","volume":"1","author":"S Gardner","year":"2010","journal-title":"J Forensic Res"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"e81760","DOI":"10.1371\/journal.pone.0081760","article-title":"When Whole-Genome Alignments Just Won&apos;t Work: kSNP v2 Software for Alignment-Free SNP Discovery and Phylogenetics of Hundreds of Microbial Genomes","volume":"8","author":"SN Gardner","year":"2013","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref16","unstructured":"Price MN. Fast Tree-Comparison Tools Berkeley, CA. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/meta.microbesonline.org\/fasttree\/treecmp.html\" xlink:type=\"simple\">http:\/\/meta.microbesonline.org\/fasttree\/treecmp.html<\/ext-link>."},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/sysbio\/sys062","article-title":"Dendroscope 3: an interactive tool for rooted phylogenetic trees and networks","volume":"61","author":"DH Huson","year":"2012","journal-title":"Syst Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1109\/TCBB.2010.57","article-title":"Untangling tanglegrams: comparing trees by their drawings","volume":"7","author":"B Venkatachalam","year":"2010","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"ref19","article-title":"Optimizing SNP microarray probe design for high accuracy microbial genotyping","author":"SN Gardner","year":"2013","journal-title":"J Microbio Meth"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"e2163","DOI":"10.1371\/journal.pone.0002163","article-title":"A functional gene array for detection of bacterial virulence elements","volume":"3","author":"C Jaing","year":"2008","journal-title":"PLoS ONE"},{"key":"ref21","first-page":"209","article-title":"Attenuation of Venezuelan equine encephalomyelitis virus by in vitro cultivation in guinea pig heart cells","volume":"73","author":"TO Berge","year":"1961","journal-title":"Am J Hyg"},{"key":"ref22","year":"2014"},{"key":"ref23","unstructured":"Therneau T, Atkinson B, Ripley B, Oksanen J, De&apos;ath G. mvpart: Multivariate partitioning. R package version 1.6\u20131 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cran.R-project.org\/package=mvpart\" xlink:type=\"simple\">http:\/\/cran.R-project.org\/package=mvpart<\/ext-link>."},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","article-title":"Modern Applied Statistics with S","author":"W Venables","year":"2002"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature02917","article-title":"Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous","volume":"431","author":"B Kolaczkowski","year":"2004","journal-title":"Nature"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrmicro1006","article-title":"Transmission cycles, host range, evolution and emergence of arboviral disease","volume":"2","author":"SC Weaver","year":"2004","journal-title":"Nature reviews Microbiology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4269\/ajtmh.1999.60.441","article-title":"Genetic evidence for the origins of Venezuelan equine encephalitis virus subtype IAB outbreaks","volume":"60","author":"S Weaver","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"ref28","article-title":"Current Strategic Thinking for the Development of a Trivalent Alphavirus Vaccine for Human Use","author":"DN Wolfe","year":"2014","journal-title":"The American Journal of Tropical Medicine and Hygiene"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T06:19:34Z","timestamp":1567750774000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152604"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Roques","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,7]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152604","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,7]]}}}