{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:27:06Z","timestamp":1791509226175,"version":"4.3.4"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152613","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T17:40:18Z","timestamp":1459186818000},"page":"e0152613","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability"],"prefix":"10.1371","volume":"11","author":[{"given":"Mireille A.","family":"Boink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Roffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Nazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"van Montfrans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G. M.","family":"Bolscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno C. I.","family":"Veerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2648.2010.05568.x","article-title":"Quality of life in people with venous leg ulcers: an integrative review","volume":"67","author":"RV Gonzalez-Consuegra","year":"2011","journal-title":"J Adv Nurs"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2133.2003.05222.x","article-title":"Causes, investigation and treatment of leg ulceration","volume":"148","author":"JR Mekkes","year":"2003","journal-title":"Br J Dermatol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1067\/mjd.2001.111633","article-title":"Chronic venous insufficiency and venous leg ulceration","volume":"44","author":"IC Valencia","year":"2001","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1742-4801.2006.00180.x","article-title":"Preventing venous ulcer recurrence: a review","volume":"3","author":"KR Vowden","year":"2006","journal-title":"Int Wound J"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1742-481X.2010.00660.x","article-title":"Cost-of-illness of chronic leg ulcers in Germany","volume":"7","author":"S Purwins","year":"2010","journal-title":"Int Wound J"},{"key":"ref6","article-title":"Venous leg ulcers","volume":"2011","author":"EA Nelson","year":"2011","journal-title":"BMJ Clin Evid"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"S Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"S Werner","year":"2003","journal-title":"Physiol Rev"},{"issue":"7\u20138","key":"ref9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1600-0463.2004.apm11207-0808.x","article-title":"The chemokine system\u2014a major regulator of angiogenesis in health and disease","volume":"112","author":"MM Rosenkilde","year":"2004","journal-title":"APMIS"},{"issue":"11","key":"ref10","first-page":"1399","article-title":"CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing","volume":"23","author":"S Zaja-Milatovic","year":"2008","journal-title":"Histol Histopathol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/jid.2011.245","article-title":"Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3","volume":"132","author":"KL Kroeze","year":"2012","journal-title":"J Invest Dermatol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.0022-202X.2004.22323.x","article-title":"Interleukin 6 indirectly induces keratinocyte migration","volume":"122","author":"RM Gallucci","year":"2004","journal-title":"J Invest Dermatol"},{"issue":"15","key":"ref13","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1096\/fj.00-0073com","article-title":"Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice","volume":"14","author":"RM Gallucci","year":"2000","journal-title":"FASEB J"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1189\/jlb.0802397","article-title":"Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice","volume":"73","author":"ZQ Lin","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/0022034509342951","article-title":"Histatins enhance wound closure with oral and non-oral cells","volume":"88","author":"MJ Oudhoff","year":"2009","journal-title":"J Dent Res"},{"issue":"16","key":"ref16","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1016\/S0021-9258(18)68522-9","article-title":"Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans","volume":"263","author":"FG Oppenheim","year":"1988","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"ref17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj3260039","article-title":"Synthetic histatin analogues with broad-spectrum antimicrobial activity","volume":"326","author":"EJ Helmerhorst","year":"1997","journal-title":"Biochem J"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1096\/fj.08-112003","article-title":"Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay","volume":"22","author":"MJ Oudhoff","year":"2008","journal-title":"FASEB J"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1515\/bc.2010.057","article-title":"The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity","volume":"391","author":"MJ Oudhoff","year":"2010","journal-title":"Biol Chem"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1096\/fj.09-137588","article-title":"Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold","volume":"23","author":"MJ Oudhoff","year":"2009","journal-title":"FASEB J"},{"issue":"6\u20137","key":"ref21","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.biocel.2007.10.024","article-title":"Metalloproteinases and their inhibitors: regulators of wound healing","volume":"40","author":"SE Gill","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1524-475X.2012.00789.x","article-title":"Simple wound exudate collection method identifies bioactive cytokines and chemokines in (arterio) venous ulcers","volume":"20","author":"KL Kroeze","year":"2012","journal-title":"Wound Repair Regen"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1096\/fj.11-182212","article-title":"Sortase A as a tool for high-yield histatin cyclization","volume":"25","author":"JG Bolscher","year":"2011","journal-title":"FASEB J"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.medengphy.2011.07.014","article-title":"A standardized objective method for continuously measuring the kinematics of cultures covering a mechanically damaged site","volume":"34","author":"G Topman","year":"2012","journal-title":"Med Eng Phys"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s10439-012-0545-0","article-title":"The influence of ischemic factors on the migration rates of cell types involved in cutaneous and subcutaneous pressure ulcers","volume":"40","author":"G Topman","year":"2012","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jbiomech.2012.09.015","article-title":"The natural medications for wound healing\u2014Curcumin, Aloe-Vera and Ginger\u2014do not induce a significant effect on the migration kinematics of cultured fibroblasts","volume":"46","author":"G Topman","year":"2013","journal-title":"J Biomech"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1523-1747.ep12359590","article-title":"Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9","volume":"101","author":"AB Wysocki","year":"1993","journal-title":"J Invest Dermatol"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/wound.2012.0370","article-title":"Proteases and Delayed Wound Healing","volume":"2","author":"SM McCarty","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood.V96.8.2673","article-title":"Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact","volume":"96","author":"PE Van den Steen","year":"2000","journal-title":"Blood"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1096\/fj.14-266825","article-title":"Histatin-1, a histidine-rich peptide in human saliva, promotes cell-substrate and cell-cell adhesion","volume":"29","author":"IA van Dijk","year":"2015","journal-title":"FASEB J"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1742-4801.2005.00149.x","article-title":"Wound chronicity and fibroblast senescence\u2014implications for treatment","volume":"2","author":"KG Harding","year":"2005","journal-title":"Int Wound J"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1067\/mva.2001.115379","article-title":"Senescence and the healing rates of venous ulcers","volume":"33","author":"A Stanley","year":"2001","journal-title":"J Vasc Surg"},{"issue":"9498","key":"ref33","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"V Falanga","year":"2005","journal-title":"Lancet"},{"issue":"Suppl","key":"ref34","first-page":"108","article-title":"Role of nitric oxide, nitroxidative and oxidative stress in wound healing","volume":"57","author":"A Soneja","year":"2005","journal-title":"Pharmacol Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T12:05:09Z","timestamp":1655381109000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152613"}},"subtitle":[],"editor":[{"given":"Anuja","family":"Ghorpade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152613","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}