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Payne","year":"2012","journal-title":"Health Statistics Quarterly"},{"key":"ref29","unstructured":"Prah P. Asking about Sex in General Health Surveys: Comparing Data Collected By the 2010 Health Survey for England with the Third Natsal Survey of Sexual Attitudes and Lifestyles. Oral presentation (3F4. at the 2014 STD Prevention Conference. Atlanta, GA, USA. Sexually Transmitted Diseases 2014;41(June, Supplement 1)."},{"issue":"9907","key":"ref30","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/S0140-6736(13)62035-8","article-title":"Changes in sexual attitudes and lifestyles in Britain through the life course and over time: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)","volume":"382","author":"CH Mercer","year":"2013","journal-title":"Lancet"},{"key":"ref31","unstructured":"Public Health England. Sexually transmitted infections and chlamydia screening in England, 2014. Health Protection Report 2015;9(22)."},{"key":"ref32","unstructured":"UK Clinical Research Network. UK Clinical Research Network: Portfolio Database. Measurement of chlamydia antibodies using residual GUM specimens (UKCRN 18521). 2015. 27-4-2015."},{"issue":"9907","key":"ref33","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(13)61947-9","article-title":"Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)","volume":"382","author":"P Sonnenberg","year":"2013","journal-title":"Lancet"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/sti.77.4.242","article-title":"Assessing the impact of national anti-HIV sexual health campaigns: trends in the transmission of HIV and other sexually transmitted infections in England","volume":"77","author":"A Nicoll","year":"2001","journal-title":"Sex Transm Infect"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/sextrans-2013-051074","article-title":"Chlamydia trachomatis IgG seroprevalence in the general population of the Netherlands in 1996 and in 2007: differential changes by gender and age","volume":"90","author":"AF van","year":"2014","journal-title":"Sex Transm Infect"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"e72001","DOI":"10.1371\/journal.pone.0072001","article-title":"C. trachomatis pgp3 Antibody Prevalence in Young Women in England, 1993\u20132010","volume":"8","author":"P Horner","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1017\/S0950268813001027","article-title":"Incidence of Chlamydia trachomatis infection in women in England: two methods of estimation","volume":"142","author":"MJ Price","year":"2014","journal-title":"Epidemiol Infect"},{"issue":"14","key":"ref38","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2013.08.020","article-title":"Development status and future prospects for a vaccine against <italic>Chlamydia trachomatis<\/italic> infection","volume":"32","author":"LM Hafner","year":"2014","journal-title":"Vaccine"},{"issue":"6241","key":"ref39","doi-asserted-by":"crossref","first-page":"aaa8205","DOI":"10.1126\/science.aaa8205","article-title":"VACCINES. 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