{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:23:48Z","timestamp":1792232628449,"version":"4.4.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0152968","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T19:55:00Z","timestamp":1459886100000},"page":"e0152968","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Charles E.","family":"Bane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Matafonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli L.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiufang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Sherwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik I.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Smiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen J. T.","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gailani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-pathol-011110-130327","article-title":"The pathogenesis of sepsis","volume":"6","author":"DJ Stearns-Kurosawa","year":"2011","journal-title":"Ann Rev Path"},{"issue":"Suppl 1","key":"ref2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1538-7836.2007.02519.x","article-title":"Fibrin and fibrinolysis in infection and host defense","volume":"5","author":"JL Degen","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"Suppl 5","key":"ref3","doi-asserted-by":"crossref","first-page":"S293","DOI":"10.1097\/01.CCM.0000128445.95144.B8","article-title":"Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis","volume":"32","author":"R Pawlinski","year":"2004","journal-title":"Crit Care Med"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.thromres.2010.01.042","article-title":"Cellular sources of tissue factor in endotoxemia and sepsis","volume":"125","author":"R Pawlinski","year":"2010","journal-title":"Thromb Res"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2174\/157016112801784549","article-title":"Crosstalk between inflammation and coagulation: the lessons of sepsis","volume":"10","author":"T van der Poll","year":"2012","journal-title":"Curr Vasc Pharmacol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0034-1398376","article-title":"Coagulation in patients with severe sepsis","volume":"41","author":"M Levi","year":"2015","journal-title":"Semin Thromb Hemost"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1055\/s-0035-1556730","article-title":"Coagulopathy of sepsis","volume":"41","author":"N Semeraro","year":"2015","journal-title":"Semin Thromb Hemost"},{"issue":"Suppl 1","key":"ref8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1538-7836.2009.03413.x","article-title":"Critical roles for thrombin in acute and chronic inflammation","volume":"7","author":"D Chen","year":"2009","journal-title":"J Thromb Haemost"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"MM Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"RP Dellinger","year":"2013","journal-title":"Intens Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"DC Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/jth.13061","article-title":"New paradigms in sepsis: from prevention to protection of failing microcirculation","volume":"13","author":"J Hawiger","year":"2015","journal-title":"J Thromb Haemost"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1182\/blood-2009-09-199182","article-title":"Structure and function of factor XI","volume":"115","author":"J Emsley","year":"2010","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1182\/asheducation-2014.1.60","article-title":"Recent insights into the role of the contact pathway in thrombo-inflammatory disorders","volume":"2014","author":"ML van Montfoort","year":"2014","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1111\/jth.13005","article-title":"Factor XI and contact activation as targets for antithrombotic therapy","volume":"13","author":"D Gailani","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"ref16","first-page":"S41","article-title":"Physiologic activities of the contact activation system","volume":"133","author":"AH Schmaier","year":"2014"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1160\/TH14-04-0311","article-title":"In vivo activation and functions of the protease factor XII","volume":"112","author":"J Bj\u00f6rkqvist","year":"2014","journal-title":"Thromb Haemost"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12959-015-0048-y","article-title":"Contact pathway of coagulation and inflammation","volume":"13","author":"Y Wu","year":"2015","journal-title":"Thromb J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1182\/asheducation-2014.1.66","article-title":"Epidemiologic and clinical data linking factors XI and XII to thrombosis","volume":"2014","author":"NS Key","year":"2014","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1086\/589514","article-title":"Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis","volume":"198","author":"EI Tucker","year":"2008","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1182\/blood-2011-10-386185","article-title":"Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis","volume":"119","author":"EI Tucker","year":"2012","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/01.shk.0000101673.49265.5d","article-title":"Hemodynamic and cardiac contractile function during sepsis caused by cecal ligation and puncture in mice","volume":"21","author":"W Tao","year":"2004","journal-title":"Shock"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0002-9440(10)63401-3","article-title":"A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model","volume":"165","author":"JG Ganopolsky","year":"2004","journal-title":"Am J Path"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1128\/IAI.64.11.4733-4738.1996","article-title":"Balance of inflammatory cytokines related to severity and mortality of murine sepsis","volume":"64","author":"KR Walley","year":"1996","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"D Rittirsch","year":"2009","journal-title":"Nat Protoc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00001721-199703000-00008","article-title":"A murine model of factor XI deficiency","volume":"8","author":"D Gailani","year":"1997","journal-title":"Blood Coag Fibrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1182\/blood-2010-02-270918","article-title":"A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo","volume":"116","author":"Q Cheng","year":"2010","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"23596","DOI":"10.1074\/jbc.M114.569061","article-title":"Inhibition of plasma kallikrein by a highly specific active site blocking antibody","volume":"289","author":"JA Kenniston","year":"2014","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1160\/TH04-04-0250","article-title":"Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo","volume":"92","author":"HU Pauer","year":"2004","journal-title":"Thromb Haemost"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nm.2295","article-title":"Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein","volume":"17","author":"J Liu","year":"2011","journal-title":"Nat Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2015.05.001","article-title":"Biological actions of pentraxins","volume":"73","author":"G Vilahur","year":"2015","journal-title":"Vascul Pharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/cc7144","article-title":"Lymphocytes, apoptosis and sepsis: making the jump from mice to humans","volume":"13","author":"JD Lang","year":"2009","journal-title":"Criticial Care"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.thromres.2010.12.002","article-title":"Animal models of DIC and their relevance to human DIC: a systematic review","volume":"128","author":"LO Berthelsen","year":"2011","journal-title":"Thromb Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1111\/j.1582-4934.2009.00884.x","article-title":"Polyphosphate and omptins: novel bacterial procoagulant agents","volume":"13","author":"TH Yun","year":"2009","journal-title":"J Cell Mol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo","volume":"139","author":"F M\u00fcller","year":"2009","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1160\/TH12-08-0634","article-title":"Molecular circuits in thrombosis and inflammation","volume":"109","author":"CT Esmon","year":"2013","journal-title":"Thromb Haemost"},{"issue":"Suppl 1","key":"ref37","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1111\/jth.12977","article-title":"Extracellular DNA and histones: double-edged swords in immunothrombosis","volume":"13","author":"TJ Gould","year":"2015","journal-title":"J Thromb Haemost"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1182\/blood.V81.12.3313.3313","article-title":"Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers","volume":"81","author":"R DeLa Cadena","year":"1993","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.immuni.2011.02.008","article-title":"Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo","volume":"34","author":"C Oschatz","year":"2011","journal-title":"Immunity"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0049-3848(78)90301-8","article-title":"Falls in plasma levels of prekallikrein, high molecular weight kininogen, and kallikrein inhibitors during lethal endotoxin shock in dogs","volume":"12","author":"MJ Gallimore","year":"1978","journal-title":"Thromb Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1073\/pnas.73.11.4179","article-title":"Identification of prekallikrein and high-molecular weight kininogen as a complex in human plasma","volume":"73","author":"RJ Mandle","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1172\/JCI108898","article-title":"Association of factor XI and high molecular weight kininogen in human plasma","volume":"60","author":"RE Thompson","year":"1977","journal-title":"J Clin Invest"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1073\/pnas.76.10.4862","article-title":"Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain","volume":"76","author":"RE Thompson","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","first-page":"18","article-title":"Activation and function of human Hageman factor","volume":"60","author":"HL Meier","year":"1977","journal-title":"The role of high molecular weight kininogen and prekallikrein J Clin Invest"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1073\/pnas.74.10.4636","article-title":"Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein","volume":"74","author":"RC Wiggins","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1182\/blood-2011-05-355248","article-title":"Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding","volume":"118","author":"AS Revenko","year":"2011","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJM200003093421004","article-title":"High levels of coagulation factor XI as a risk factor for venous thrombosis","volume":"342","author":"JC Meijers","year":"2000","journal-title":"N Engl J Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1182\/blood-2005-12-023697","article-title":"Levels of intrinsic coagulation factors and risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII","volume":"108","author":"CJ Doggen","year":"2006","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000297966","article-title":"Novel hemostatic factor levels and risk of ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"29","author":"MF Suri","year":"2010","journal-title":"Cerebrovasc Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.drudis.2014.05.018","article-title":"Factor XI as a target for antithrombotic therapy","volume":"19","author":"CE Bane Jr.","year":"2014","journal-title":"Drug Discov Today"},{"issue":"Suppl 1","key":"ref51","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/00024382-199610001-00007","article-title":"Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis","volume":"6","author":"A Ayala","year":"1996","journal-title":"Shock"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1538-7836.2010.03853.x","article-title":"Polymicrobial sepsis and endotoxemia promote microvascular thrombosis via distinct mechanisms","volume":"8","author":"KN Patel","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0002-9440(10)62329-2","article-title":"Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models","volume":"166","author":"J Corral","year":"2005","journal-title":"Am J Pathol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00005344-199805000-00016","article-title":"Streptokinase-induced activation of the kallikrein-kinin system and of the contact phase in patients with acute myocardial infarction","volume":"31","author":"HM Hoffmeister","year":"1998","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.CIR.91.1.28","article-title":"Plasmin-mediated activation of contact system in response to pharmacologic thrombolysis","volume":"91","author":"GA Ewald","year":"1995","journal-title":"Circulation"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/00365540310016268","article-title":"Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis","volume":"35","author":"H Herwald","year":"2003","journal-title":"Scand J Infect Dis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1160\/TH07-01-0051","article-title":"The dual role of the contact system in bacterial infectious disease","volume":"98","author":"IM Frick","year":"2007","journal-title":"Thromb Haemost"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.1073\/pnas.89.24.11969","article-title":"Induction of expression of monocyte interleukin 1 by Hageman factor (factor XII)","volume":"89","author":"Z Toossi","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1161\/01.ATV.0000240290.70852.c0","article-title":"High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes","volume":"26","author":"MM Khan","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref60","first-page":"1","article-title":"Basic and clinical aspects of bradykinin receptor antagonists","volume":"69","author":"JN Sharma","year":"2014","journal-title":"Prog Drug Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/1570161112666140226121627","article-title":"Kinin receptors in vascular biology and pathology","volume":"12","author":"R Couture","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI116201","article-title":"The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons","volume":"91","author":"RA Pixley","year":"1993","journal-title":"J Clin Invest"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/j.1538-7836.2008.03142.x","article-title":"A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice","volume":"6","author":"T Iwaki","year":"2008","journal-title":"J Thromb Haemost"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1111\/j.1538-7836.2008.03143.x","article-title":"Evolution of the contact phase of vertebrate blood coagulation","volume":"6","author":"MB Ponczek","year":"2008","journal-title":"J Thromb Haemost"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1021\/bi00222a008","article-title":"Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains","volume":"30","author":"BA McMullen","year":"1991","journal-title":"Biochemistry"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/bi00357a017","article-title":"Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats","volume":"25","author":"DW Chung","year":"1986","journal-title":"Biochemistry"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/jth.12275","article-title":"Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa","volume":"11","author":"Y Geng","year":"2013","journal-title":"J Thromb Haemost"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/blood-2010-10-312983","article-title":"Activation of factor XI by products of prothrombin activation","volume":"118","author":"A Matafonov","year":"2011","journal-title":"Blood"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1084\/jem.147.2.488","article-title":"Characterization of human high molecular weight kininogen. Procoagulant activity associated with the light chain of kinin-free high molecular weight kininogen","volume":"147","author":"RE Thompson","year":"1978","journal-title":"J Exp Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"10856","DOI":"10.1016\/S0021-9258(19)85161-X","article-title":"Cleavage of human high molecular weight kininogen by factor XIa in vitro. Effect on structure and function","volume":"260","author":"CF Scott","year":"1985","journal-title":"J Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1073\/pnas.75.4.1998","article-title":"Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII)","volume":"75","author":"JH Griffin","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"165974","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets\u2014An Updated View","volume":"2013","author":"W Schulte","year":"2013","journal-title":"Mediators of Inflammation"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5492\/wjccm.v4.i2.105","article-title":"Anticoagulant modulation of inflammation in severe sepsis","volume":"4","author":"KS Allen","year":"2015","journal-title":"World J Crit Care Med"},{"key":"ref74","unstructured":"Schmidt GA, Clardy PF, Investigational and ineffective therapies for sepsis. UptoDate. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.uptodate.com\/contents\/investigational-and-ineffective-therapies-for-sepsis\" xlink:type=\"simple\">http:\/\/www.uptodate.com\/contents\/investigational-and-ineffective-therapies-for-sepsis<\/ext-link>"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0152968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T04:32:41Z","timestamp":1655440361000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0152968"}},"subtitle":[],"editor":[{"given":"Jian","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,5]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0152968","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,5]]}}}